Movement by Bacteria: On the Mechanism of Sensory Transduction in Bacterial Chemotaxis

Sensory Transduction provides a thorough and easily accessible introduction to the mechanisms that each of the different kinds of sensory receptor cell uses to convert a sensory stimulus into an electrical response. Beginning with an introduction to methods of experimentation, sensory specializations, ion channels, and G-protein cascades, it provides up-to-date reviews of all of the major senses, including touch, hearing, olfaction, taste, photoreception, and the “extra” senses of thermoreception, electroreception, and magnetoreception. By bringing mechanisms of all of the senses together into a coherent treatment, it facilitates comparison of ion channels, metabotropic effector molecules, second messengers, and other components of signal pathways that are common themes in the physiology of the different sense organs. With its many clear illustrations and easily assimilated exposition, it provides an ideal introduction to current research for the professional in neuroscience, as well as a text for an advanced undergraduate or graduate-level course on sensory physiology.

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Requirement of ATP in bacterial chemotaxis.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)34283-2 ◽

1982 ◽

Vol 257 (14) ◽

pp. 7969-7975 ◽

Cited By ~ 1

Author(s):

J I Shioi ◽

R J Galloway ◽

M Niwano ◽

R E Chinnock ◽

B L Taylor

Keyword(s):

Bacterial Chemotaxis

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Odontoblast TRPC5 channels signal cold pain in teeth

Science Advances ◽

10.1126/sciadv.abf5567 ◽

2021 ◽

Vol 7 (13) ◽

pp. eabf5567

Author(s):

Laura Bernal ◽

Pamela Sotelo-Hitschfeld ◽

Christine König ◽

Viktor Sinica ◽

Amanda Wyatt ◽

...

Keyword(s):

Relative Sensitivity ◽

Cellular Component ◽

Sensory Transduction ◽

Cold Sensation ◽

Cold Pain ◽

Sensing System ◽

Cold Sensitive ◽

Cellular Components ◽

Cold Sensor ◽

Cold Sensing

Teeth are composed of many tissues, covered by an inflexible and obdurate enamel. Unlike most other tissues, teeth become extremely cold sensitive when inflamed. The mechanisms of this cold sensation are not understood. Here, we clarify the molecular and cellular components of the dental cold sensing system and show that sensory transduction of cold stimuli in teeth requires odontoblasts. TRPC5 is a cold sensor in healthy teeth and, with TRPA1, is sufficient for cold sensing. The odontoblast appears as the direct site of TRPC5 cold transduction and provides a mechanism for prolonged cold sensing via TRPC5’s relative sensitivity to intracellular calcium and lack of desensitization. Our data provide concrete functional evidence that equipping odontoblasts with the cold-sensor TRPC5 expands traditional odontoblast functions and renders it a previously unknown integral cellular component of the dental cold sensing system.

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