Prophylaxis of Cerebral Ischemic Damage From Vasospasm After Subarachnoid Hemorrhage

1983 ◽  
pp. 124-133 ◽  
Author(s):  
L. M. Auer
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Ischemic Damage ◽  
Cerebral Ischemic ◽  
Cerebral Ischemic Damage

The Biochemical Basis of Cerebral Ischemic Damage

1995 ◽  
Vol 7 (1) ◽  
pp. 47-52 ◽  
Author(s):  
Bo K. Siesj?? ◽  
Ken-ichiro Katsura ◽  
Tibor Kristi??n
Keyword(s):  
Ischemic Damage ◽  
Biochemical Basis ◽  
Cerebral Ischemic ◽  
Cerebral Ischemic Damage

scholarly journals Nrf2 Plays an Essential Role in Long-Term Brain Damage and Neuroprotection of Korean Red Ginseng in a Permanent Cerebral Ischemia Model

Antioxidants ◽  
2019 ◽  
Vol 8 (8) ◽  
pp. 273 ◽  
Author(s):  
Lei Liu ◽  
Marie G. Kelly ◽  
Erika L. Wierzbicki ◽  
Iana C. Escober-Nario ◽  
Mary K. Vollmer ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Infarct Volume ◽  
Regulatory Protein ◽  
Reactive Gliosis ◽  
Ischemic Damage ◽  
Red Ginseng ◽  
Korean Red Ginseng ◽  
Cerebral Ischemic ◽  
Cerebral Ischemic Damage

Cerebral ischemia is a devastating disease with a high incidence of death and disability; however, effective therapeutics remain limited. The transcriptional factor Nrf2 has been shown to play a pivotal role in the endogenous defense against brain oxidative stress and inflammation, and therefore represents a promising target for stroke intervention. However, the long-term effects of Nrf2 and the standardized Korean red ginseng (ginseng), a potent Nrf2 natural inducer, on permanent cerebral ischemic damage have not yet been reported. Wildtype (WT) and Nrf2-/- adult mice were pretreated with either vehicle or ginseng, and were subjected to permanent distal middle cerebral artery occlusion (pdMCAO). The infarct volume, the reactive astrocytes and microglia, and the water regulatory protein aquaporin 4 (AQP4) were examined at 28 days after stroke. When compared with the WT matched controls, the Nrf2 disruption significantly enlarged the infarct volume (40.4 ± 10.1%) and exacerbated the progression of reactive gliosis and AQP4 protein levels after pdMCAO. In contrast, ginseng significantly reduced the infarct volume and attenuated the reactive gliosis and AQP4 in the ischemic WT mice (47.3 ± 6.9%), but not in the Nrf2-/- mice (25.5 ± 5.6%). In conclusion, Nrf2 plays an important role in the long-term recovery of permanent cerebral ischemic damage and the neuroprotection of ginseng.

Cilostazol: Therapeutic Potential Against Focal Cerebral Ischemic Damage

2006 ◽  
Vol 12 (5) ◽  
pp. 565-573 ◽  
Author(s):  
Ki Hong ◽  
Jeong Lee ◽  
Ki Kim ◽  
So Park ◽  
Won Lee
Keyword(s):  
Therapeutic Potential ◽  
Ischemic Damage ◽  
Cerebral Ischemic ◽  
Cerebral Ischemic Damage
Sign in / Sign up

Export Citation Format

Share Document