Histopathology of Early Laryngeal Carcinoma

1984 ◽  
pp. 31-36 ◽  
Author(s):  
L. H. Weiland
Keyword(s):  
Laryngeal Carcinoma

p53 Expression in laryngeal carcinoma

Pathology ◽  
1993 ◽  
Vol 25 (4) ◽  
pp. 394-397 ◽  
Author(s):  
Guy Boag ◽  
C. Soon Lee ◽  
Dora Charalambous ◽  
Jürgen Rode
Keyword(s):  
Laryngeal Carcinoma ◽  
P53 Expression

Cáncer de laringe y sinunasal en Cali, Colombia 1962 – 2015 / Sinonasal and laryngeal carcinoma in Cali, Colombia 1962 – 2015

2019 ◽  
Vol 46 (4) ◽  
pp. 269-278
Author(s):  
María Fernanda Urrea ◽  
Ángela María Jiménez ◽  
Jorge Holguín ◽  
José María Barreto ◽  
María Cecilia Osorio ◽  
...  
Keyword(s):  
Laryngeal Carcinoma

Introducción: El cáncer es una enfermedad de alta incidencia, con múltiples factores etiológicos y diferentes características evolutivas. Objetivo: Describir la supervivencia y la tendencia de las tasas de incidencia y mortalidad por cáncer de laringe y senos paranasales en Cali (Colombia) durante el periodo 1962 a 2015. Diseño: Estudio observacional descriptivo. Métodos: La información de incidencia, durante el periodo 1962 a 2012, se obtuvo en el RPCC y la mortalidad entre 1984-2015 de la SSPM. Elcomportamiento de la tendencia se evaluó con el porcentaje de cambio anual (APC) y la supervivencia relativa se estimó con el método de Ederer II. La estadificación se realizó con la AJCC. Resultados: Durante 1962 a 2012, se diagnosticaron 1623 casos nuevos de cáncer, 85.2% (1383 casos) fueron de laringe y 14.8% (240 casos) sinunasal 76% fueron hombres y el CCE fue el tipo histológico más frecuente 84.1% y 59.6% en laringe y sinunasal respectivamente. Se observó una disminución significativa del riesgo de cáncer de laringe en ambos sexos, siendo mayor la disminución en hombres (APC=-1,1*(ICD95%: -1,6; -0,7)). La disminución en la tasa de incidencia de cáncer de laringe CEC fue mayor en hombres (APC=-1,1*(ICD95%: -1,6; -0,6)) durante 1962-2012. Las tasas de mortalidad disminuyeron significativamente (APC=-2,5 (ICD95%:-3,6 -1,5)). La supervivencia relativa a 5 años durante el periodo 2008-2012, 43,5%; 93 pacientes se estadificaron con supervivencia: T3-T4 (41,5%) y T1-T2 (55,0%). Conclusiones: El riesgo del cáncer de laringe y sinunasal escamocelular asociado al tabaquismo disminuyó de manera significativa en hombres y mujeres de Cali durante los últimos 53 años.

Relationship of local recurrence with expression of protein P53 and PCNA in laryngeal carcinoma and its surgical margins

2009 ◽  
Vol 28 (4) ◽  
pp. 413-417
Author(s):  
Guang-bin SUN ◽  
Hai-hong TANG ◽  
Qin FANG ◽  
Shui-miao ZHOU ◽  
Zhao-ji LI
Keyword(s):  
Local Recurrence ◽  
Laryngeal Carcinoma ◽  
Surgical Margins ◽  
Protein P53 ◽  
Relationship Of

Efficacy of nimotuzumab (hR3) conjugated with 131I or 90Y in laryngeal carcinoma xenograft mouse model

2021 ◽  
pp. 1-34
Author(s):  
Thi-Thu Nguyen ◽  
Anh-Son Ho ◽  
Thi-Khanh-Giang Nguyen ◽  
Thi-Ngoc Nguyen ◽  
Van-Cuong Bui ◽  
...  
Keyword(s):  
Mouse Model ◽  
Laryngeal Carcinoma ◽  
Xenograft Mouse Model ◽  
Carcinoma Xenograft

scholarly journals The Prognostic Value of Preoperative Plasma Fibrinogen and Neutrophil-to-Lymphocyte Ratio in Patients With Laryngeal Squamous Cell Carcinoma

2020 ◽  
pp. 014556132092074
Author(s):  
Hao Cai ◽  
Zi-Heng Zhang ◽  
Yu-Jie Zhou ◽  
Ji Liu ◽  
Huan-Qi Chen ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Laryngeal Carcinoma ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Neutrophil To Lymphocyte Ratio ◽  
Plasma Fibrinogen ◽  
Optimal Cutoff ◽  
Lymphocyte Ratio ◽  
Cutoff Values

Objectives: Treatment effects in patients with laryngeal squamous cell carcinoma may vary significantly even among those with the same TNM stage. Routine preoperative blood and coagulation tests are economical and easily available hematological indicators. This study aimed to investigate the clinical predictive significance of pretreatment evaluation of plasma fibrinogen (FIB) level, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) in patients with laryngeal carcinoma. Methods: Clinicopathological and demographic data from 203 patients who underwent surgery for laryngeal carcinoma were collected and analyzed. The optimal cutoff values for FIB, NLR, and PLR were determined using receiver operating characteristic curve analysis. Univariate and multivariate Cox regression analyses were used to study the relationship between blood markers and patient survival. Results: The optimal cutoff values for FIB, NLR, and PLR were 3.05 g/L, 2.41, and 110.94, respectively. Preoperative hyperfibrinemia (FIB >3.05 g/L) was an independent prognostic factor for overall survival (OS) and disease-free survival in patients with laryngeal carcinoma. An NLR >2.41 was associated with reduced OS in patients with laryngeal carcinoma, while PLR >110.94 had no effect on prognosis in these patients. Conclusions: Fibrinogen and NLR were valuable markers in predicting survival in patients with laryngeal carcinoma and may be used to inform clinicians in designing individual treatment strategies.

Does thyroid-sparing total laryngectomy decrease the risk of hypothyroidism?

2020 ◽  
pp. 1-4
Author(s):  
G Viljoen ◽  
J K McGuire ◽  
A Alhadad ◽  
S Dalvie ◽  
J J Fagan
Keyword(s):  
South Africa ◽  
Retrospective Study ◽  
Laryngeal Carcinoma ◽  
Adjuvant Radiotherapy ◽  
Total Laryngectomy ◽  
Inclusion Criteria ◽  
Nccn Guidelines ◽  
Thyroid Lobectomy ◽  
Cancer Network ◽  
Advanced Laryngeal Carcinoma

Abstract Background Thyroid lobectomy is recommended with total laryngectomy for laryngeal cancer in the National Comprehensive Cancer Network (‘NCCN’) guidelines. However, it is associated with a 32–89 per cent risk of hypothyroidism, with or without adjuvant radiotherapy. Objective The study aimed to determine whether preserving the whole thyroid, compared to a single lobe, does indeed significantly lower the incidence of hypothyroidism in the setting of total laryngectomy. Method A retrospective study was conducted at Groote Schuur Hospital in Cape Town, South Africa. Results Eighty-four patients met the inclusion criteria. The overall incidence of hypothyroidism was 45.2 per cent. The incidence of hypothyroidism was significantly reduced in patients who underwent thyroid-sparing total laryngectomy compared to hemithyroidectomy (p = 0.037). Adjuvant radiotherapy was associated with a higher incidence of hypothyroidism (p = 0.001). Conclusion Thyroid-preserving laryngectomy should be advocated in carefully selected patients with advanced laryngeal carcinoma, as it reduces the incidence of hypothyroidism.

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