Control of Epstein-Barr Virus-Related Disease

1987 ◽  
pp. 170-180
Author(s):  
H. Wolf
Keyword(s):  
Epstein Barr Virus ◽  
Barr Virus ◽  
Related Disease ◽  
Epstein Barr

scholarly journals Laboratory Assays for Epstein-Barr Virus-Related Disease

2008 ◽  
Vol 10 (4) ◽  
pp. 279-292 ◽  
Author(s):  
Margaret L. Gulley ◽  
Weihua Tang
Keyword(s):  
Epstein Barr Virus ◽  
Barr Virus ◽  
Related Disease ◽  
Epstein Barr

scholarly journals Bone marrow transplant recipients have defective MHC-unrestricted cytotoxic responses against cytomegalovirus in comparison with Epstein- Barr virus: the importance of target cell expression of lymphocyte function-associated antigen 1 (LFA1)

Blood ◽  
1992 ◽  
Vol 79 (11) ◽  
pp. 3059-3066 ◽  
Author(s):  
AS Duncombe ◽  
JE Grundy ◽  
P Oblakowski ◽  
HG Prentice ◽  
DJ Gottlieb ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Adhesion Molecule ◽  
Peripheral Blood ◽  
Epstein Barr Virus ◽  
Target Cells ◽  
Lymphocyte Function ◽  
Effector Cells ◽  
Barr Virus ◽  
Related Disease ◽  
Epstein Barr

Abstract Cytomegalovirus (CMV) remains the most common single infective cause of death following allogeneic bone marrow transplantation (BMT) from major histocompatibility complex (MHC)-identical siblings, whereas Epstein- Barr virus (EBV)-related disease is infrequent. We show here that MHC- unrestricted cytotoxic effector cells in the peripheral blood of BMT recipients are highly effective at killing EBV-infected target cells, but are inactive against CMV-infected target cells. Differential cytotoxicity is associated with disparate target structure expression. Although both EBV- and CMV-infected target cells express viral antigens, it is only those infected with EBV that express the adhesion molecule lymphocyte function-associated antigen 1 (LFA1; CD11a/18). Thus, EBV-infected target cells are able to interact with the principal LFA1 ligand, intercellular adhesion molecule 1 (ICAM1; CD54), which is expressed on posttransplant peripheral blood mononuclear (PBM) effector cells. CMV-infected target cells cannot utilize this ligand. Posttransplant cytotoxicity against EBV-infected target cells is abolished by target and effector cell blockade with monoclonal antibodies (MoAbs) to LFA1 and ICAM1, respectively, demonstrating the functional relevance of this additional ligand interaction. These results provide an illustration both of the importance and of the limitations of MHC-unrestricted cytotoxicity in vivo and may explain the frequency of CMV disease and the relative rarity of EBV-related disease following allogeneic transplantation from MHC-matched siblings. The increased immunosuppression used following MHC-mismatched/matched unrelated-donor BMT may cause this MHC-unrestricted defense mechanism to fail and may contribute to the greatly increased incidence of EBV lymphoproliferative syndrome in these patients.

Epstein-Barr virus in the enlarged salivary tissues of patients with IgG4-related disease

2015 ◽  
Vol 125 (9) ◽  
pp. 2079-2084 ◽  
Author(s):  
Takatoshi Furukawa ◽  
Yoshitaka Shimotai ◽  
Nobuo Ohta ◽  
Akihiro Ishida ◽  
Kazuya Kurakami ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Barr Virus ◽  
Related Disease ◽  
Igg4 Related Disease ◽  
Epstein Barr

Epstein-Barr Virus–infected Cells in IgG4-related Lymphadenopathy With Comparison With Extranodal IgG4-related Disease

2014 ◽  
Vol 38 (7) ◽  
pp. 946-955 ◽  
Author(s):  
Mai Takeuchi ◽  
Yasuharu Sato ◽  
Hiroshi Yasui ◽  
Hiroaki Ozawa ◽  
Kyotaro Ohno ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Barr Virus ◽  
Related Disease ◽  
Igg4 Related Disease ◽  
Infected Cells ◽  
Epstein Barr

scholarly journals Bone marrow transplant recipients have defective MHC-unrestricted cytotoxic responses against cytomegalovirus in comparison with Epstein- Barr virus: the importance of target cell expression of lymphocyte function-associated antigen 1 (LFA1)

Blood ◽  
1992 ◽  
Vol 79 (11) ◽  
pp. 3059-3066
Author(s):  
AS Duncombe ◽  
JE Grundy ◽  
P Oblakowski ◽  
HG Prentice ◽  
DJ Gottlieb ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Adhesion Molecule ◽  
Peripheral Blood ◽  
Epstein Barr Virus ◽  
Target Cells ◽  
Lymphocyte Function ◽  
Effector Cells ◽  
Barr Virus ◽  
Related Disease ◽  
Epstein Barr

Cytomegalovirus (CMV) remains the most common single infective cause of death following allogeneic bone marrow transplantation (BMT) from major histocompatibility complex (MHC)-identical siblings, whereas Epstein- Barr virus (EBV)-related disease is infrequent. We show here that MHC- unrestricted cytotoxic effector cells in the peripheral blood of BMT recipients are highly effective at killing EBV-infected target cells, but are inactive against CMV-infected target cells. Differential cytotoxicity is associated with disparate target structure expression. Although both EBV- and CMV-infected target cells express viral antigens, it is only those infected with EBV that express the adhesion molecule lymphocyte function-associated antigen 1 (LFA1; CD11a/18). Thus, EBV-infected target cells are able to interact with the principal LFA1 ligand, intercellular adhesion molecule 1 (ICAM1; CD54), which is expressed on posttransplant peripheral blood mononuclear (PBM) effector cells. CMV-infected target cells cannot utilize this ligand. Posttransplant cytotoxicity against EBV-infected target cells is abolished by target and effector cell blockade with monoclonal antibodies (MoAbs) to LFA1 and ICAM1, respectively, demonstrating the functional relevance of this additional ligand interaction. These results provide an illustration both of the importance and of the limitations of MHC-unrestricted cytotoxicity in vivo and may explain the frequency of CMV disease and the relative rarity of EBV-related disease following allogeneic transplantation from MHC-matched siblings. The increased immunosuppression used following MHC-mismatched/matched unrelated-donor BMT may cause this MHC-unrestricted defense mechanism to fail and may contribute to the greatly increased incidence of EBV lymphoproliferative syndrome in these patients.

A case of Epstein–Barr virus-related lymphadenopathy mimicking the clinical features of IgG4-related disease

2013 ◽  
Vol 23 (3) ◽  
pp. 597-603 ◽  
Author(s):  
Yoko Wada ◽  
Masaru Kojima ◽  
Kazuhiro Yoshita ◽  
Mihoko Yamazaki ◽  
Daisuke Kobayashi ◽  
...  
Keyword(s):  
Clinical Features ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Related Disease ◽  
Igg4 Related Disease ◽  
Epstein Barr
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