Icosanoids, Chromosome Damage and Cancer

1987 ◽  
pp. 29-34 ◽  
Author(s):  
I. Emerit
Keyword(s):  
Chromosome Damage

Chromosome damage caused by enzymically generated active oxygen species

1983 ◽  
Vol 18 ◽  
pp. 47
Author(s):  
B.J. Phillips ◽  
T.E.B. James ◽  
D. Anderson
Keyword(s):  
Active Oxygen Species ◽  
Active Oxygen ◽  
Chromosome Damage ◽  
Oxygen Species

Specificity of Chromosome Damage Caused by the Rex Element of Drosophila melanogaster

Genetics ◽  
1996 ◽  
Vol 144 (1) ◽  
pp. 109-115 ◽  
Author(s):  
Leonard G Robbins
Keyword(s):  
Drosophila Melanogaster ◽  
Early Development ◽  
X Chromosome ◽  
Ribosomal Rna ◽  
Chromosome Damage ◽  
Genetic Element ◽  
Single Chromosome ◽  
Experimental Cross ◽  
Rdna Array ◽  
Early Embryos

Abstract Rex is a multicopy genetic element that maps within an X-linked ribosomal RNA gene (rDNA) array of D. melanogaster. Acting maternally, Rex causes recombination between rDNA arrays in a few percent of early embryos. With target chromosomes that contain two rDNA arrays, the exchanges either delete all of the material between the two arrays or invert the entire intervening chromosomal segment. About a third of the embryos produced by Rex homozygotes have cytologically visible chromosome damage, nearly always involving a single chromosome. Most of these embryos die during early development, displaying a characteristic apoptosis-like phenotype. An experiment that tests whether the cytologically visible damage is rDNA-specific is reported here. In this experiment, females heterozygous for Rex and an rDNA-deficient X chromosome were crossed to males of two genotypes. Some of the progeny from the experimental cross entirely lacked rDNA, while all of the progeny from the control cross had at least one rDNA array. A significantly lower frequency of early-lethal embryos in the experimental cross, proportionate to the fraction of rDNA-deficient embryos, demonstrates that Rex preferentially damages rDNA.

scholarly journals Chromosome Damage in Down's Syndrome Induced by Chickenpox Infection

1976 ◽  
Vol 10 (3) ◽  
pp. 189-192 ◽  
Author(s):  
Makoto Higurash ◽  
Aiko Tada ◽  
Shinobu Miyahara ◽  
Munehiro Hirayama ◽  
Hiroki Hoshina ◽  
...  
Keyword(s):  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Chromosome Damage
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