Immune Responses Against Myelin Basic Protein and/or Galactocerebroside Cross-React with Viruses: Implications for Demyelinating Disease

1989 ◽  
pp. 93-100 ◽  
Author(s):  
R. S. Fujinami
Keyword(s):  
Immune Responses ◽  
Myelin Basic Protein ◽  
Basic Protein ◽  
Demyelinating Disease

A quantitation of myelin-associated glycoprotein and myelin basic protein loss in different demyelinating disease

1985 ◽  
Vol 18 (3) ◽  
pp. 324-328 ◽  
Author(s):  
Howard E. Gendelman ◽  
Gholam H. Pezeshkpour ◽  
Norman J. Pressman ◽  
Jerry S. Wolinsky ◽  
Richard H. Quarles ◽  
...  
Keyword(s):  
Myelin Basic Protein ◽  
Basic Protein ◽  
Demyelinating Disease ◽  
Protein Loss ◽  
Myelin Associated Glycoprotein

scholarly journals Surface Layer Protein A Expressed in Clostridioides difficile DJNS06-36 Possesses an Encephalitogenic Mimotope of Myelin Basic Protein

2020 ◽  
Vol 9 (1) ◽  
pp. 34
Author(s):  
John E. Mindur ◽  
Sudhir K. Yadav ◽  
Naoko Ito ◽  
Mitsutoshi Senoh ◽  
Haru Kato ◽  
...  
Keyword(s):  
T Cells ◽  
Surface Layer ◽  
Amino Acid ◽  
Myelin Basic Protein ◽  
Basic Protein ◽  
Demyelinating Disease ◽  
Protein A ◽  
Enteric Bacteria ◽  
Surface Layer Protein ◽  
Clostridioides Difficile

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). Recent studies suggest that migration of Th1 and Th17 cells specific for enteric bacteria from the gut to the CNS may lead to the initiation and/or exacerbation of autoimmune diseases including MS. Human leukocyte antigen (HLA)-DR15 is an MHC class II (MHCII) haplotype highly associated with the development of MS that contains the two HLA-DRB* genes, DRB1*1501 (DR2b) and DRB5*0101 (DR2a). To identify enteric bacteria which harbor antigenic epitopes that activate myelin-specific T cells and drive CNS inflammation, we screened for enteric bacteria which express cross-reactive epitopes (‘mimotopes’) of an immunodominant myelin basic protein 89–98 (MBP89-98) epitope. Based on known MHCII HLA-DR2a amino acid binding motifs and cultivation with splenic T cells isolated from MBP-T cell receptor (TCR)/DR2a transgenic (Tg) mice, we discovered that a certain variant of surface layer protein A (SLPA), which is expressed by a subtype of Clostridioides difficile, contains an amino acid sequence that activates MBP89-98-reactive T cells. Furthermore, activation of MBP-specific T cells by SLPA upon active immunization induced experimental autoimmune encephalomyelitis (EAE) in MBP-TCR/DR2a Tg mice. This study suggests that a unique strain of C. difficile possesses an encephalitogenic mimotope of MBP that activates autoreactive, myelin-specific T cells.

scholarly journals Altered peptide ligands of myelin basic protein (MBP87���99) conjugated to reduced mannan modulate immune responses in mice

Immunology ◽  
2009 ◽  
Vol 128 (4) ◽  
pp. 521-533 ◽  
Author(s):  
Maria Katsara ◽  
Elizabeth Yuriev ◽  
Paul A. Ramsland ◽  
Theodore Tselios ◽  
George Deraos ◽  
...  
Keyword(s):  
Immune Responses ◽  
Myelin Basic Protein ◽  
Basic Protein ◽  
Peptide Ligands ◽  
Altered Peptide Ligands
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