Anaerobic Pyruvate Metabolism in Enterobacteria: The Radical Enzyme, Pyruvate Formate-Lyase

1990 ◽  
pp. 31-39
Author(s):  
J. Knappe
Keyword(s):  
Pyruvate Metabolism ◽  
Pyruvate Formate Lyase

scholarly journals EFFECT OF FURACIN ON PYRUVATE METABOLISM

1956 ◽  
Vol 219 (1) ◽  
pp. 463-471
Author(s):  
M.F. Paul ◽  
Melvin J. Bryson ◽  
Catherine Harrington
Keyword(s):  
Pyruvate Metabolism

scholarly journals Microrna-130a Downregulates HCV Replication through an atg5-Dependent Autophagy Pathway

Cells ◽  
2019 ◽  
Vol 8 (4) ◽  
pp. 338 ◽  
Author(s):  
Xiaoqiong Duan ◽  
Xiao Liu ◽  
Wenting Li ◽  
Jacinta A. Holmes ◽  
Annie J. Kruger ◽  
...  
Keyword(s):  
Immune Responses ◽  
Binding Sites ◽  
Target Gene ◽  
Target Genes ◽  
Pyruvate Metabolism ◽  
Host Immune Responses ◽  
Qrt Pcr ◽  
Antiviral Genes ◽  
Autophagy Pathway ◽  
Host Antiviral Response

We previously identified that miR-130a downregulates HCV replication through two independent pathways: restoration of host immune responses and regulation of pyruvate metabolism. In this study, we further sought to explore host antiviral target genes regulated by miR-130a. We performed a RT² Profiler™ PCR array to identify the host antiviral genes regulated by miR-130a. The putative binding sites between miR-130a and its downregulated genes were predicted by miRanda. miR-130a and predicted target genes were over-expressed or knocked down by siRNA or CRISPR/Cas9 gRNA. Selected gene mRNAs and their proteins, together with HCV replication in JFH1 HCV-infected Huh7.5.1 cells were monitored by qRT-PCR and Western blot. We identified 32 genes that were significantly differentially expressed more than 1.5-fold following miR-130a overexpression, 28 of which were upregulated and 4 downregulated. We found that ATG5, a target gene for miR-130a, significantly upregulated HCV replication and downregulated interferon stimulated gene expression. miR-130a downregulated ATG5 expression and its conjugation complex with ATG12. ATG5 and ATG5-ATG12 complex affected interferon stimulated gene (ISG) such as MX1 and OAS3 expression and subsequently HCV replication. We concluded that miR-130a regulates host antiviral response and HCV replication through targeting ATG5 via the ATG5-dependent autophagy pathway.

scholarly journals Reproducibility study for free-breathing measurements of pyruvate metabolism using hyperpolarized 13 C in the heart

2013 ◽  
Vol 69 (4) ◽  
pp. spcone-spcone
Author(s):  
Angus Z. Lau ◽  
Albert P. Chen ◽  
Jennifer Barry ◽  
John J. Graham ◽  
William Dominguez-Viqueira ◽  
...  
Keyword(s):  
Free Breathing ◽  
Pyruvate Metabolism ◽  
Reproducibility Study

Pyruvate Formate Lyase:  A New Perspective

2003 ◽  
Vol 107 (24) ◽  
pp. 5751-5757 ◽  
Author(s):  
Maria de Fátima Lucas ◽  
Pedro Alexandrino Fernandes ◽  
Leif A. Eriksson ◽  
Maria João Ramos
Keyword(s):  
Pyruvate Formate Lyase ◽  
New Perspective

Effect of Dietary Theophylline on Pyruvate Metabolism and Respiratory Activities in Liver Mitochondria

1972 ◽  
Vol 140 (4) ◽  
pp. 1472-1476 ◽  
Author(s):  
B. Friend ◽  
M. A. Mehlman ◽  
V. Devore ◽  
R. B. Tobin
Keyword(s):  
Liver Mitochondria ◽  
Pyruvate Metabolism

Pyruvate metabolism by trichomonads

1986 ◽  
Vol 14 (6) ◽  
pp. 1274-1274
Author(s):  
A. CHAPMAN ◽  
D. LLOYD ◽  
D. J. LINSTEAD ◽  
J. WILLIAMS
Keyword(s):  
Pyruvate Metabolism

?Cerebral? lactic acidosis: defects in pyruvate metabolism with profound brain damage and minimal systemic acidosis

1988 ◽  
Vol 147 (1) ◽  
pp. 10-14 ◽  
Author(s):  
G. K. Brown ◽  
E. A. Haan ◽  
D. M. Kirby ◽  
R. D. Scholem ◽  
J. E. Wraith ◽  
...  
Keyword(s):  
Lactic Acidosis ◽  
Brain Damage ◽  
Pyruvate Metabolism
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