The Ischemic Penumbra: Fact or Fiction?

1991 ◽  
pp. 60-66 ◽  
Author(s):  
B. K. Siesjö ◽  
H. Memezawar
Keyword(s):  
Ischemic Penumbra

scholarly journals Hypoxia and Hypotension Transform the Blood Flow Response to Cortical Spreading Depression from Hyperemia into Hypoperfusion in the Rat

2008 ◽  
Vol 28 (7) ◽  
pp. 1369-1376 ◽  
Author(s):  
Inna Sukhotinsky ◽  
Ergin Dilekoz ◽  
Michael A Moskowitz ◽  
Cenk Ayata
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cortical Spreading Depression ◽  
Spreading Depression ◽  
Ischemic Penumbra ◽  
Doppler Flowmetry ◽  
Blood Flow Response ◽  
Flow Response ◽  
Normal Rat ◽  
Cortex Cérébral

Cortical spreading depression (CSD) evokes a large cerebral blood flow (CBF) increase in normal rat brain. In contrast, in focal ischemic penumbra, CSD-like periinfarct depolarizations (PID) are mainly associated with hypoperfusion. Because PIDs electrophysiologically closely resemble CSD, we tested whether conditions present in ischemic penumbra, such as tissue hypoxia or reduced perfusion pressure, transform the CSD-induced CBF response in nonischemic rat cortex. Cerebral blood flow changes were recorded using laser Doppler flowmetry in rats subjected to hypoxia, hypotension, or both. Under normoxic normotensive conditions, CSD caused a characteristic transient CBF increase (74 ± 7%) occasionally preceded by a small hypoperfusion (−4 ± 2%). Both hypoxia ( pO2 45 ± 3 mm Hg) and hypotension (blood pressure 42 ± 2 mm Hg) independently augmented this initial hypoperfusion (−14 ± 2% normoxic hypotension; −16 ± 6% hypoxic normotension; −21 ± 5% hypoxic hypotension) and diminished the magnitude of hyperemia (44 ± 10% normoxic hypotension; 43 ± 9% hypoxic normotension; 27 ± 6% hypoxic hypotension). Hypotension and, to a much lesser extent, hypoxia increased the duration of hypoperfusion and the DC shift, whereas CSD amplitude remained unchanged. These results suggest that hypoxia and/or hypotension unmask a vasoconstrictive response during CSD in the rat such that, under nonphysiologic conditions (i.e., mimicking ischemic penumbra), the hyperemic response to CSD becomes attenuated resembling the blood flow response during PIDs.

Phenotyping of anin VitroModel of Ischemic Penumbra by iTRAQ-Based Shotgun Quantitative Proteomics

2010 ◽  
Vol 9 (1) ◽  
pp. 472-484 ◽  
Author(s):  
Arnab Datta ◽  
Jung Eun Park ◽  
Xin Li ◽  
Huoming Zhang ◽  
Zhi Shan Ho ◽  
...  
Keyword(s):  
Quantitative Proteomics ◽  
Ischemic Penumbra

Thromboxane synthetase inhibition with imidazole increases blood flow in ischemic penumbra

Neurosurgery ◽  
1988 ◽  
Vol 22 (2) ◽  
pp. 317???23 ◽  
Author(s):  
M W Roy ◽  
R J Dempsey ◽  
D E Cowen ◽  
D L Donaldson ◽  
A B Young
Keyword(s):  
Blood Flow ◽  
Ischemic Penumbra ◽  
Thromboxane Synthetase

Spontaneous astrocytic Ca2+ activity abounds in electrically suppressed ischemic penumbra of aged mice

Glia ◽  
2018 ◽  
Vol 67 (1) ◽  
pp. 37-52 ◽  
Author(s):  
Jonas Christoffer Fordsmann ◽  
Reena Prity Murmu ◽  
Changsi Cai ◽  
Alexey Brazhe ◽  
Kirsten Joan Thomsen ◽  
...  
Keyword(s):  
Ischemic Penumbra ◽  
Aged Mice

scholarly journals Application of Multimodal MRI in Cerebral Infarction

2020 ◽  
Vol 8 (2) ◽  
Author(s):  
Mengjiao Wei
Keyword(s):  
Early Detection ◽  
Cerebral Infarction ◽  
Transient Ischemic Attack ◽  
Clinical Treatment ◽  
Intracranial Artery ◽  
Ischemic Penumbra ◽  
Infarct Area ◽  
Intracranial Artery Stenosis ◽  
Multimodal Mri ◽  
Ischemic Attack

 Symptomatic atherosclerotic intracranial artery stenosis often causes ischemic cerebral infarction or transient ischemic attack in the stenosis area. Early detection of cerebral infarction and evaluation of ischemic penumbra and hemodynamics in the infarct area Information plays an extremely important role in clinical treatment and prognosis. This article briefly introduces the application of multimodal MRI in cerebral infarction.

scholarly journals Thresholds in cerebral ischemia - the ischemic penumbra.

Stroke ◽  
1981 ◽  
Vol 12 (6) ◽  
pp. 723-725 ◽  
Author(s):  
J Astrup ◽  
B K Siesjö ◽  
L Symon
Keyword(s):  
Cerebral Ischemia ◽  
Ischemic Penumbra
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