The Oncogenic Potential of Epstein-Barr Virus Nuclear Antigen 1 in Transgenic Mice

1992 ◽  
pp. 375-384 ◽  
Author(s):  
J. B. Wilson ◽  
A. J. Levine
Keyword(s):  
Transgenic Mice ◽  
Epstein Barr Virus ◽  
Nuclear Antigen ◽  
Oncogenic Potential ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Epstein-Barr Virus Nuclear Antigen 1 Does Not Cause Lymphoma in C57BL/6J Mice

2008 ◽  
Vol 82 (8) ◽  
pp. 4180-4183 ◽  
Author(s):  
Myung-Soo Kang ◽  
Vishal Soni ◽  
Roderick Bronson ◽  
Elliott Kieff
Keyword(s):  
Transgenic Mice ◽  
Epstein Barr Virus ◽  
Latent Infection ◽  
Nuclear Antigen ◽  
Barr Virus ◽  
Epstein Barr ◽  
Negative Controls ◽  
Mouse Lymphocytes

ABSTRACT To test whether transgenic Epstein-Barr virus nuclear antigen 1 (EBNA1) expression in C57BL/6 mouse lymphocytes causes lymphoma, EBNA1 expressed in three FVB lineages at two or three times the level of latent infection was crossed up to six successive times into C57BL/6J mice. After five or six crosses, 14/36, (38%) EBNA1 transgenic mice, 11/31 (36%) littermate EBNA1-negative controls, and 9/25 (36%) inbred C57BL/6J mice housed in the same facility had lymphoma. These data indicate that EBNA1 does not significantly increase lymphoma prevalence in C57BL/6J mice.

Ultrastructural Characterization of Hearts from Transgenic Mice Expressing the Epstein-Barr Virus Nuclear Antigen-Leader Protein

1999 ◽  
Vol 5 (S2) ◽  
pp. 1172-1173
Author(s):  
J.R. Megill ◽  
T. M. Monticello ◽  
M.H. French ◽  
P.L. Smith ◽  
N.C. Trippodo ◽  
...  
Keyword(s):  
Heart Failure ◽  
Transgenic Mice ◽  
Epstein Barr Virus ◽  
Transgenic Line ◽  
Complex Life Cycle ◽  
Nuclear Antigen ◽  
Barr Virus ◽  
Nuclear Antigens ◽  
Leader Protein ◽  
Epstein Barr

Mice expressing the Epstein-Barr virus nuclear antigen-leader protein (EBNA-LP) develop congestive heart failure and atrial thrombosis as early as four months of age. Epstein-Barr virus (EBV) is a common human herpes virus with a complex life cycle involving chronic replication in epithelial tissues. The EBNA-LP, one of six EBV nuclear antigens, has an unknown biochemical function but is associated with EBV-induced growth transformation. This transgenic line was originally produced to investigate oncogenic consequences, but unexpectedly resulted in mice with progressive heart failure. Since the progression and development of the heart failure is highly predictable, this transgenic line may serve as a valuable model for studying the pathophysiologic changes associated with human dilated cardiomyopathy. We describe here the ultrastructural characteristics of the myocardium from EBNA-LP transgenic mice in order to better delineate the pathogenesis of the associated heart disease.

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