Blood Purification by Hemofiltration in Septic Shock and Multiple Organ Dysfunction Syndrome Patients

1995 ◽  
pp. 311-323 ◽  
Author(s):  
A. F. Grootendorst ◽  
J. L. C. M. van Saase
Keyword(s):  
Septic Shock ◽  
Organ Dysfunction ◽  
Multiple Organ Dysfunction Syndrome ◽  
Multiple Organ ◽  
Blood Purification ◽  
Multiple Organ Dysfunction

scholarly journals Fluid balance correlates with clinical course of multiple organ dysfunction syndrome and mortality in patients with septic shock

PLoS ONE ◽  
2019 ◽  
Vol 14 (12) ◽  
pp. e0225423
Author(s):  
Allen Chung-Cheng Huang ◽  
Tim Yu-Ting Lee ◽  
Meng-Cheng Ko ◽  
Chih-Hsien Huang ◽  
Tsai-Yu Wang ◽  
...  
Keyword(s):  
Septic Shock ◽  
Organ Dysfunction ◽  
Multiple Organ Dysfunction Syndrome ◽  
Fluid Balance ◽  
Clinical Course ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction

scholarly journals To what extent are the terminal stages of sepsis, septic shock, SIRS, and multiple organ dysfunction syndrome actually driven by a prion/amyloid form of fibrin?

2016 ◽  
Author(s):  
Douglas B. Kell ◽  
Etheresia Pretorius
Keyword(s):  
Septic Shock ◽  
Organ Dysfunction ◽  
Multiple Organ Dysfunction Syndrome ◽  
Disseminated Intravascular Coagulation ◽  
Prion Diseases ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction ◽  
Therapeutic Value ◽  
Helical Content ◽  
Β Sheets

AbstractA well-established development of increasing disease severity leads from sepsis through septic shock, SIRS, multiple organ dysfunction syndrome and cellular and organismal death. We argue that a chief culprit is the LPS-induced anomalous coagulation of fibrinogen to produce a form of fibrin that is at once inflammatory, resistant to fibrinolysis, and underpins the disseminated intravascular coagulation commonly observed in sepsis. In particular, we argue that the form of fibrin produced is anomalous because much of its normal α-helical content is transformed to β-sheets, as occurs in established amyloidogenic and prion diseases. We hypothesise that these processes play a major role in the passage along the above pathways to organismal death, and that inhibiting them would be of great therapeutic value, a claim for which there is emerging evidence.

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