Protein Kinase C and Lipid Signalling for Cellular Regulation

1995 ◽  
pp. 29-47
Author(s):  
Shun-ichi Nakamura ◽  
Kouji Ogita ◽  
Yasutomi Nishizuka ◽  
Yoshinori Asaoka ◽  
Françoise Hullin
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Cellular Regulation ◽  
Lipid Signalling ◽  
Kinase C

scholarly journals The Family of Protein Kinase C in Transmembrane Signalling for Cellular Regulation

1992 ◽  
Vol 38 (Special) ◽  
pp. 7-12 ◽  
Author(s):  
Y. ASAOKA ◽  
K. YOSHIDA ◽  
M. OKA ◽  
T. SHINOMURA ◽  
H. KOIDE ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Cellular Regulation ◽  
Transmembrane Signalling ◽  
Kinase C ◽  
The Family

Analysis of a protein kinase C-α mutation in human pituitary tumours

1997 ◽  
Vol 153 (1) ◽  
pp. 131-137 ◽  
Author(s):  
U Schiemann ◽  
R Assert ◽  
D Moskopp ◽  
R Gellner ◽  
K Hengst ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Pituitary Adenomas ◽  
Pituitary Tumours ◽  
Cellular Regulation ◽  
Human Pituitary ◽  
Non Invasive ◽  
Kinase C ◽  
Regulation Of Growth ◽  
Important Enzyme

Abstract It is generally accepted that protein kinase C-α (PKC-α) is an important enzyme in the cellular regulation of growth and differentiation by phosphorylating proteins. Recent studies have described a point mutation of PKC-α (position 908 of the genetic sequence, codon GAC becoming GGC) in invasive human pituitary tumours which leads to an exchange of amino acids in the protein. We investigated 11 human pituitary tumours to evaluate the data obtained previously. cDNA was subcloned and up to ten individual clones were sequenced from each tumour, resulting in 85 clones analyzed in total. All of the pituitary adenomas showed a normal wild-type sequence of PKC-α DNA. Even if the tumour was 'invasive' (infiltration of the dura mater) no mutation at position 908 of the sequence was found. Moreover, using Western blot analyses we did not observe any differences in PKC-α protein expression in invasive as compared with non-invasive pituitary adenomas. Until now we have been unable to confirm the data of other investigators, suggesting that mutated PKC-α is an inconsistent feature of invasive pituitary tumours. Journal of Endocrinology (1997) 153, 131–137

scholarly journals Protein kinase C: poised to signal

2010 ◽  
Vol 298 (3) ◽  
pp. E395-E402 ◽  
Author(s):  
Alexandra C. Newton
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Cell Surface ◽  
Family Members ◽  
Cell Disruption ◽  
Regulatory Mechanisms ◽  
Cellular Regulation ◽  
Specific Lipids ◽  
Allosteric Activation ◽  
Kinase C

Nestled at the tip of a branch of the kinome, protein kinase C (PKC) family members are poised to transduce signals emanating from the cell surface. Cell membranes provide the platform for PKC function, supporting the maturation of PKC through phosphorylation, its allosteric activation by binding specific lipids, and, ultimately, promoting the downregulation of the enzyme. These regulatory mechanisms precisely control the level of signaling-competent PKC in the cell. Disruption of this regulation results in pathophysiological states, most notably cancer, where PKC levels are often grossly altered. This review introduces the PKC family and then focuses on recent advances in understanding the cellular regulation of its diacylglycerol-regulated members.

Roles of Protein Kinase C Isozymes in Cellular Regulation

1989 ◽  
pp. 21-28 ◽  
Author(s):  
Kuo-Ping Huang ◽  
Freesia L. Huang ◽  
Hiroki Nakabayashi ◽  
Yasuyoshi Yoshida
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Cellular Regulation ◽  
Kinase C
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