Radiotherapy of Malignant Gliomas

Glioma ◽  
1991 ◽  
pp. 121-124
Author(s):  
A. B. M. F. Karim ◽  
E. van der Schueren ◽  
D. G. Gonzalez ◽  
M. van Glabbeke
Keyword(s):  
Malignant Gliomas

Nucleic Acid-based Technologies in Therapy of Malignant Gliomas

2011 ◽  
Vol 12 (11) ◽  
pp. 1805-1822 ◽  
Author(s):  
Monika Piwecka ◽  
Katarzyna Rolle ◽  
Eliza Wyszko ◽  
Ryszard Zukiel ◽  
Stanislaw Nowak ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Malignant Gliomas

Recent Advances in Experimental Molecular Therapeutics for Malignant Gliomas

2004 ◽  
Vol 4 (4) ◽  
pp. 347-361 ◽  
Author(s):  
Gautam Prasad ◽  
Hui Wang ◽  
Donald Hill ◽  
Ruiwen Zhang
Keyword(s):  
Malignant Gliomas ◽  
Molecular Therapeutics ◽  
Recent Advances

Targeted Radiotherapy for Malignant Gliomas

2012 ◽  
Vol 9 (4) ◽  
pp. 268-279 ◽  
Author(s):  
Daniel S. Oh ◽  
David C. Adamson ◽  
John P. Kirkpatrick
Keyword(s):  
Malignant Gliomas ◽  
Targeted Radiotherapy

Application of Targeted Therapy to Malignant Gliomas and Response to Treatment

2013 ◽  
Vol 8 (1) ◽  
pp. 14-24 ◽  
Author(s):  
Eudocia Q. Lee ◽  
Andrew D. Norden ◽  
Jan Drappatz ◽  
Patrick Y. Wen
Keyword(s):  
Targeted Therapy ◽  
Malignant Gliomas ◽  
Response To Treatment

The role of microRNAs in gliomas – Therapeutic implications

2020 ◽  
Vol 13 ◽  
Author(s):  
Theodora Katsila ◽  
Dimitrios Kardamakis
Keyword(s):  
Complex Disease ◽  
Malignant Gliomas ◽  
Kappa Statistic ◽  
Individual Variability ◽  
Response To Treatment ◽  
Disease Phenotype ◽  
Therapeutic Implications ◽  
Non Invasive ◽  
Gene Environment ◽  
Sas Macro

Background: Malignant gliomas constitute a complex disease phenotype that demands optimum decisionmaking. Despite being the most common type of primary brain tumors, gliomas are highly heterogeneous when their pathophysiology and response to treatment are considered. Such inter-individual variability also renders differential and early diagnosis extremely difficult. Recent evidence highlight that the gene-environment interplay becomes of fundamental importance in oncogenesis and progression of gliomas. Objective: To unmask key features of the gliomas disease phenotype and map the inter-individual variability of patients, we explore genotype-to-phenotype associations. Emphasis is put on microRNAs as they regulate gene expression, have been implicated in the pathogenesis of gliomas and may serve as theranostics, empowering non-invasive strategies (circulating free or in exosomes). Method: We mined text and omic datasets (as of 2019) and conducted a mixed-method content analysis. A novel framework was developed to meet the aims of our analysis, interrogating data in terms of content and context. We relied on literature data from PubMed/Medline and Scopus, as they are considered the largest abstract and citation databases of peer-reviewed literature. To avoid selection biases, both publicly available and private texts have been assessed. Both percent agreement and Cohen's kappa statistic have been calculated to avoid biases by SAS macro MAGREE with multicategorical ratings. Results: Gliomas serve as a paradigm for multifaceted datasets, despite data sparsity and scarcity. miRNAs and miRNAbased therapeutics are ready for prime time. Exosomal miRNAs empower non-invasive strategies, surpassing circulating free miRNAs, when accuracy and precision are considered. Conclusion: miRNAs holds promise as theranostics.

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