Protein kinase C in the transduction of signals toward and within the cell nucleus

EJB Reviews ◽  
1995 ◽  
pp. 43-53
Author(s):  
Klaus Buchner
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Cell Nucleus ◽  
Kinase C

scholarly journals The protein kinase C-related PKC-L(eta) gene product is localized in the cell nucleus.

1992 ◽  
Vol 12 (3) ◽  
pp. 1304-1311 ◽  
Author(s):  
H Greif ◽  
J Ben-Chaim ◽  
T Shimon ◽  
E Bechor ◽  
H Eldar ◽  
...  
Keyword(s):  
Gene Expression ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Cell Nucleus ◽  
Molecular Mechanisms ◽  
Phorbol Esters ◽  
Subcellular Fractionation ◽  
Related Family ◽  
Kinase C ◽  
Human Epidermoid Carcinoma

The tumor promoters phorbol esters are thought to induce changes in cell growth and gene expression by direct activation of protein kinase C (PKC). However, the molecular mechanisms by which PKC molecules transduce signals into the cell nucleus are unknown. In this study, we provide evidence for a direct target for phorbol esters in the nucleus. We demonstrate that the new PKC-related family member, PKC-L, recently isolated by us, is expressed specifically in the cell nucleus. Localization of PKC-L in the cell nucleus is shown both by immunofluorescence staining and by subcellular fractionation experiments of several human cell lines, including the human epidermoid carcinoma line A431. Treatment of these cells by phorbol esters does not induce the down-regulation of PKC-L, in contrast to their effect on classical PKC family members. This is the only PKC isoenzyme described so far that resides permanently and specifically in the cell nucleus. PKC-L may function as an important link in tumor promoting, e.g., as a nuclear regulator of gene expression that changes the phosphorylation state of transcriptional components such as the AP-1 complex.

The protein kinase C-related PKC-L(eta) gene product is localized in the cell nucleus

1992 ◽  
Vol 12 (3) ◽  
pp. 1304-1311
Author(s):  
H Greif ◽  
J Ben-Chaim ◽  
T Shimon ◽  
E Bechor ◽  
H Eldar ◽  
...  
Keyword(s):  
Gene Expression ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Cell Nucleus ◽  
Molecular Mechanisms ◽  
Phorbol Esters ◽  
Subcellular Fractionation ◽  
Related Family ◽  
Kinase C ◽  
Human Epidermoid Carcinoma

The tumor promoters phorbol esters are thought to induce changes in cell growth and gene expression by direct activation of protein kinase C (PKC). However, the molecular mechanisms by which PKC molecules transduce signals into the cell nucleus are unknown. In this study, we provide evidence for a direct target for phorbol esters in the nucleus. We demonstrate that the new PKC-related family member, PKC-L, recently isolated by us, is expressed specifically in the cell nucleus. Localization of PKC-L in the cell nucleus is shown both by immunofluorescence staining and by subcellular fractionation experiments of several human cell lines, including the human epidermoid carcinoma line A431. Treatment of these cells by phorbol esters does not induce the down-regulation of PKC-L, in contrast to their effect on classical PKC family members. This is the only PKC isoenzyme described so far that resides permanently and specifically in the cell nucleus. PKC-L may function as an important link in tumor promoting, e.g., as a nuclear regulator of gene expression that changes the phosphorylation state of transcriptional components such as the AP-1 complex.

Dictyostelium protein kinase C-delta-like protein is localized in the cell nucleus

1996 ◽  
Vol 86 (2-3) ◽  
pp. 103-109 ◽  
Author(s):  
Yingcai Wang ◽  
Hila Rubin ◽  
Shoshana Ravid
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Cell Nucleus ◽  
Protein Kinase C Delta ◽  
Kinase C

Identification of PSF as a protein kinase C?-binding protein in the cell nucleus

2002 ◽  
Vol 86 (2) ◽  
pp. 394-402 ◽  
Author(s):  
Uwe Rosenberger ◽  
Ingo Lehmann ◽  
Christoph Weise ◽  
Peter Franke ◽  
Ferdinand Hucho ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Cell Nucleus ◽  
Binding Protein ◽  
Kinase C
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