Ultrastructure of Hyperacute Rejection in Cardiac Xenografts

1991 ◽  
pp. 243-251 ◽  
Author(s):  
A. G. Rose ◽  
D. K. C. Cooper
Keyword(s):  
Hyperacute Rejection

Never functioning kidney transplants and non-classical hyperacute rejection

1991 ◽  
Vol 32 ◽  
pp. 106
Author(s):  
S. Vaidya ◽  
J.A. Ruth ◽  
N.P. Orchard ◽  
N.E. Schroeder ◽  
R.W. Haneke ◽  
...  
Keyword(s):  
Hyperacute Rejection ◽  
Kidney Transplants ◽  
Functioning Kidney

Characteristics of hyperacute rejection of swine kidney xenografts perfused with canine blood

1976 ◽  
Vol 8 (4) ◽  
pp. 323-329 ◽  
Author(s):  
T. Tóth ◽  
E. Rőth ◽  
T. Szmolenszky ◽  
S. Pácsa ◽  
B. Török
Keyword(s):  
Hyperacute Rejection ◽  
Swine Kidney

scholarly journals Effect of Hyperkalemia and Hemolysis Caused by Hyperacute Rejection on Cardiac Function in Pig to HumanEx VivoXenogeneic Cardiac Perfusion Model

2011 ◽  
Vol 41 (3) ◽  
pp. 130 ◽  
Author(s):  
Jun Seok Kim ◽  
Hak-Mo Lee ◽  
Byoung Chol Oh ◽  
Hong-Gook Lim ◽  
Jeong Ryul Lee
Keyword(s):  
Cardiac Function ◽  
Hyperacute Rejection ◽  
Cardiac Perfusion ◽  
Perfusion Model

scholarly journals Synergistic suppression of pre-perfusion of donor livers with recipient serum and cobra venom factor treatment on hyperacute rejection following liver xenotransplantation

2012 ◽  
Vol 27 (5) ◽  
pp. 301-305 ◽  
Author(s):  
Baohua Zhu ◽  
Chuanming Tong ◽  
Weitao Guo ◽  
Rong Pu ◽  
Guoping Zhang ◽  
...  
Keyword(s):  
Survival Time ◽  
Hyperacute Rejection ◽  
Cobra Venom ◽  
Control Group ◽  
Sprague Dawley ◽  
Donor Liver ◽  
Cobra Venom Factor ◽  
Sd Rats ◽  
Sprague Dawley Rats ◽  
And Control

PURPOSE: To investigate synergistic suppression of donor liver pre-perfusion with recipient serum (RS) and cobra venom factor (CVF) treatment on hyperacute rejection (HAR) following liver xenotransplantation. METHODS: Guinea-pigs (GP, n=24) and Sprague-Dawley rats (SD, n=24) were recruited. Before transplantation, serum was collected from SD rats and used for preparation of inactivated complements. GP and SD rats were randomly assigned into four groups (n=6), respectively: RS group, CVF group, RS+CVF group and control group. Orthotopic liver xenotransplantation was performed with modified two-cuff technique. The survival time and liver function of recipients, morphological and pathological changes in rat livers were investigated. RESULTS: There was no piebald like change in the recipient livers in all experiment groups. The survival time of recipients in all experiment groups was longer than that in control group (p<0.05). Moreover, the survival time in the RS+CVF group was markedly longer than that in the RS group (p<0.01) and CVF group (p<0.05). The serum ALT level in all experiment groups were lower than that in the control group (p<0.05). Furthermore, the ALT level in the RS+CVF group was significantly lower than that in the CVF group (p<0.05) and RS group (p<0.01). The histological damages were significantly improved when compared with the control group, and the histological damages in the RS+CVF group were milder than those in the remaining groups (p<0.05) CONCLUSION: Pre-perfusion of donor liver with recipient serum and cobra venom factor treatment can exert synergistic suppressive effects on the hyperacute rejection following liver xenotransplantation.

α-Galactosyl Oligosaccharides Conjugated with Polyethylene Glycol as Potential Inhibitors of Hyperacute Rejection upon Xenotransplantation

1997 ◽  
Vol 232 (3) ◽  
pp. 731-736 ◽  
Author(s):  
Takaharu Nagasaka ◽  
Takaaki Kobayashi ◽  
Hisako Muramatsu ◽  
Hiroshi Fujimoto ◽  
Ichiro Matsuo ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Hyperacute Rejection ◽  
Potential Inhibitors

HYPERACUTE REJECTION FOLLOWING PREOPERATIVE DONOR SPECIFIC CELL TRANSFUSION IS ASSOCIATED WITH A LOSS OF HEMATOPOETIC CHIMERISM

2008 ◽  
Vol 86 (Supplement) ◽  
pp. 729-730
Author(s):  
B Kruse ◽  
S Thissen ◽  
G Warnecke ◽  
M Avsar ◽  
F Länger ◽  
...  
Keyword(s):  
Hyperacute Rejection ◽  
Specific Cell

Cytolytic assessment of hyperacute rejection and production of nuclear transfer embryos using hCD46-transgenic porcine embryonic germ cells

Zygote ◽  
2009 ◽  
Vol 17 (2) ◽  
pp. 101-108 ◽  
Author(s):  
Ji Young Won ◽  
Kwang Sung Ahn ◽  
Alice M. Sorrell ◽  
Susa Shin ◽  
Soon Young Heo ◽  
...  
Keyword(s):  
Nuclear Transfer ◽  
Regulatory Protein ◽  
Blastocyst Stage ◽  
Hyperacute Rejection ◽  
Complement Regulatory Protein ◽  
Transgenic Pigs ◽  
Embryonic Germ Cells ◽  
Transgenic Embryos ◽  
Stage Analysis ◽  
Human Xenotransplantation

SummaryHuman complement regulatory protein hCD46 may reduce the hyperacute rejection (HAR) in pig-to-human xenotransplantation. In this study, an hCD46 gene was introduced into porcine embryonic germ (EG) cells. Treatment of human serum did not affect the survival of hCD46-transgenic EG cells, whereas the treatment significantly reduced the survival of non-transgenic EG cells (p < 0.01). The transgenic EG cells presumably capable of alleviating HAR were transferred into enucleated oocytes. Among 235 reconstituted oocytes, 35 (14.9%) developed to the blastocyst stage. Analysis of individual embryos indicated that 80.0% (28/35) of embryos contained the transgene hCD46. The result of the present study demonstrates resistance of hCD46-transgenic EG cells against HAR, and the usefulness of the transgenic approach may be predicted by this cytolytic assessment prior to actual production of transgenic pigs. Subsequently performed EG cell nuclear transfer gave rise to hCD46-transgenic embryos. Further study on the transfer of these embryos to recipients may produce hCD46-transgenic pigs.

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