Development of a Simulator of Cardiac Function Estimation for before and after Left Ventricular Plasty Surgery

2007 ◽  
pp. 605-616
Author(s):  
Tatsushi Tokuyasu ◽  
Akito Ichiya ◽  
Tadashi Kitamura ◽  
Genichi Sakaguchi ◽  
Masashi Komeda
Keyword(s):  
Cardiac Function ◽  
Left Ventricular ◽  
Function Estimation ◽  
Before And After

Cardiac function in systemic hypertension before and after reversal of left ventricular hypertrophy

1988 ◽  
Vol 62 (10) ◽  
pp. 745-750 ◽  
Author(s):  
Bruno Trimarco ◽  
Nicola De Luca ◽  
Bruno Ricciardelli ◽  
Giovanni Rosiello ◽  
Massimo Volpe ◽  
...  
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Cardiac Function ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Systemic Hypertension ◽  
Before And After

Exercise Assessment of Cardiac Function in Children and Young Adults Before and After Bone Marrow Transplantation

PEDIATRICS ◽  
1992 ◽  
Vol 89 (4) ◽  
pp. 722-729
Author(s):  
Ranae L. Larsen ◽  
Gerald Barber ◽  
Charles T. Heise ◽  
Charles S. August
Keyword(s):  
Bone Marrow ◽  
Young Adults ◽  
Bone Marrow Transplantation ◽  
Cardiac Function ◽  
Marrow Transplantation ◽  
Cardiac Toxicity ◽  
Intensive Therapy ◽  
Left Ventricular ◽  
Before And After ◽  
Children And Young Adults

Cardiac toxicity is a potential complication of bone marrow transplantation because recipients frequently receive cardiotoxic chemotherapy and/or irradiation before transplantation. Most studies indicate that transient cardiac toxicity occurs within weeks of transplantation, but few studies have evaluated either cardiac status before or late after transplantation. Cardiac performance was assessed via cycle ergometry in 20 children and young adults before transplantation and 31 other children and young adults after transplantation. Mean survival time in the group post-transplantation was 3.9 years with a range of 11 months to 12.1 years. Left ventricular size and shortening fraction at rest were assessed via echocardiography. Data were compared to those of 70 healthy subjects from our laboratory. Patients before and after transplantation had normal oxygen consumptions and cardiac indices at rest. During exercise, however, patients treated for cancer both before and after bone marrow transplantation had reduced exercise times, reduced maximal oxygen consumptions, and reduced ventilatory anaerobic thresholds. Cardiac reserve, as judged by the response of the cardiac output during exercise, was reduced severely. There were no significant differences between the groups tested before and after transplantation. Patients who had been treated for aplastic anemia, who had received less intensive therapy before transplantation, performed significantly better than did patients treated for cancer. Despite these findings, only four patients had abnormalities by echocardiography. In conclusion, before transplantation patients with oncologic diagnoses had serious limitations in exercise performance, most likely as a result of the effects of the cardiotoxic therapy given as part of their conventional cancer therapy. Long-term survivors of bone marrow transplantation also had similar abnormalities. Since the same patients were not studied before and after transplantation, one cannot draw definite conclusions about the effect of the transplantation itself upon cardiac function. However, exercise testing is a sensitive, noninvasive method of assessing patients at risk for cardiac dysfunction secondary to potentially cardiotoxic agents.

A Simulation for Cardiac Function Evaluation before and after Left Ventricular Plasty

2004 ◽  
Vol 2004.5 (0) ◽  
pp. 69-70
Author(s):  
Tatsushi TOKUYASU ◽  
Akito ICHIYA ◽  
Tadashi KITAMURA ◽  
Genichi SAKAGUCHI ◽  
Masashi KOMEDA
Keyword(s):  
Cardiac Function ◽  
Left Ventricular ◽  
Function Evaluation ◽  
Before And After

Exercise alters Cardiac Function Independent of Acute Systemic Inflammation in Healthy Men

2021 ◽  
Author(s):  
Alexandra M. Coates ◽  
Heather L. Petrick ◽  
Philip J. Millar ◽  
Jamie F. Burr
Keyword(s):  
Cardiac Function ◽  
Inflammatory Cytokines ◽  
Vascular Function ◽  
Ventilatory Threshold ◽  
A Priori ◽  
Left Ventricular ◽  
Flow Mediated Dilation ◽  
Left Ventricular Stiffness ◽  
Main Effect ◽  
Before And After

Acute elevations in inflammatory cytokines have been demonstrated to increase aortic and left ventricular stiffness and reduce endothelial function in healthy subjects. As vascular and cardiac function are often transiently reduced following prolonged exercise, it is possible that cytokines released during exercise may contribute to these alterations. The a priori aims of this study were to determine if vaccine-induced increases in inflammatory-cytokines would reduce vascular and left ventricular function, whether vascular alterations would drive cardiac impairments, and whether this would be potentiated by moderate exercise. In a randomized cross-over fashion, sixteen male participants were tested under control (CON) and inflammatory (INF) conditions, wherein INF testing occurred 8h following administration of an influenza vaccine. On both days, participants underwent measures of echocardiography performed during light cycling (stress-echocardiography), carotid-femoral pulse wave velocity (cf-PWV), and superficial femoral flow-mediated dilation (FMD) before and after cycling for 90min at ~85% of their first ventilatory threshold. IL-6 increased significantly (∆1.9±1.3pg/mL, P<0.001), while TNFα was non-significantly augmented (∆0.05±0.11pg/mL, P=0.09), 8h following vaccination. Vascular function was unaltered following cycling or inflammation (all P>0.05). The use of echocardiography during light cycling revealed cardiac alterations traditionally expected to occur only with greater exercise loads, with reduced systolic (e.g. longitudinal strain CON:∆3.3±4.4%, INF:∆1.7±2.7%, P=0.002) and diastolic function (e.g. E/A ratio CON:∆-0.32±0.34a.u., INF:∆-0.25±0.27a.u., P=0.002) following cycling, independent of inflammation. The vaccine reduced stroke volume (SV) (main effect of condition P=0.009) before-and-after cycling. These findings indicate that reduced cardiac function following exercise occurs largely independent of additional inflammatory load.

Influence of Transmyocardial Laser Revascularization (TMLR) on Regional Cardiac Function and Metabolism in an Isolated Hemoperfused Working Pig Heart

2002 ◽  
Vol 25 (11) ◽  
pp. 1074-1081 ◽  
Author(s):  
D. Modersohn ◽  
S. Eddicks ◽  
I. Ast ◽  
S. Holinski ◽  
W. Konertz
Keyword(s):  
Cardiac Function ◽  
Clinical Symptoms ◽  
Isolated Heart ◽  
Left Ventricular Pressure ◽  
Left Ventricular ◽  
Coronary Perfusion ◽  
Intramyocardial Pressure ◽  
Ischemic Region ◽  
Transmyocardial Laser Revascularization ◽  
Before And After

The mechanism of an indirect revascularization in ischemic myocardium by transmyocardial laser revascularization (TMLR) is not yet fully understood. An improvement of clinical symptoms caused by TMLR is reported in many clinical trials with patients in which a direct revascularization is not possible. An increase of myocardial perfusion through laser channels is doubtful, because the myocardial pressure in the wall is higher than in the cavum. Therefore we measured the local cardiac function (intramyocardial pressure, wall thickness, pressure-length curves) and acute metabolic changes (tissue lactate content, tissue pO2) in ischemic and non-ischemic regions before and after TMLR in isolated hemoperfused pig hearts. An isolated heart was chosen because it enabled us to separate coronary flow from flow through ventricular channels. The ischemia was induced by coronary occlusion or microembolization (eight hearts each). It should be noted that microembolization leads to conditions which are more comparable with those found in patients selected for TMLR. In the isolated working heart, the coronary perfusion can be controlled independently from perfusion through the ventricular cavum. Under the ischemic conditions mentioned above, we observed that the intramyocardial pressure in the ischemic region decreased below the left ventricular pressure, so one premise for indirect perfusion was met. TMLR after microembolization led to a significant improvement of regional cardiac work and the tissue oxygen pressure. These acute effects demonstrate the possibility of functional and metabolic amelioration by TMLR after ischemia induced by microembolization in an isolated hemoperfused pig heart.

scholarly journals Development of a Simulator for Cardiac Function Evaluation Before and After Left Ventricular Plasty Surgery

2005 ◽  
Vol 6 (4) ◽  
pp. 467-475
Author(s):  
Tatsushi Tokuyasu ◽  
Tadashi Kitamura ◽  
Gen'ichi Sakaguchi ◽  
Masashi Komeda
Keyword(s):  
Cardiac Function ◽  
Left Ventricular ◽  
Function Evaluation ◽  
Before And After

Management of Ventricular Fibrillation during Acute Myocardial Infarction

1984 ◽  
Vol 23 (04) ◽  
pp. 209-213
Author(s):  
B. J. Northover
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Ventricular Fibrillation ◽  
Coronary Care Unit ◽  
Patient Survival ◽  
Left Ventricular ◽  
Ventricular Failure ◽  
Before And After ◽  
Coronary Care ◽  
The Creation

SummaryAnalysis of electrocardiograms tape-recorded from patients admitted to hospital with acute myocardial infarction revealed that the pattern of ventricular extrasystolic activity was not significantly different among those who subsequently developed ventricular fibrillation and those who did not. Episodes of ventricular fibrillation occurred predominantly within 4 hours from the start of infarction. Patients were 3 times less likely to survive an episode of ventricular fibrillation if they also had left ventricular failure than if this feature was absent. Management of episodes of ventricular fibrillation was compared in patients before and after the creation of a specially staffed and equipped coronary care unit. The success of electric shock as a treatment for ventricular fibrillation was similar before and after the creation of the coronary care unit. An attempt was made to determine which features in the management of ventricular fibrillation in this and in previously published series were associated with patient survival.

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