Lacrimal Gland and Salivary Gland Lesions

2013 ◽  
pp. 153-162
Author(s):  
Motohisa Yamamoto ◽  
Hiroki Takahashi ◽  
Yasuhisa Shinomura
Keyword(s):  
Salivary Gland ◽  
Lacrimal Gland

L11, a Unique Anti-CD43 Monoclonal Antibody, Inhibits the Adoptive Transfer of Diabetes and Pancreatic Islet, Salivary Gland, and Lacrimal Gland Inflammation in NOD/scid Mice

1999 ◽  
Vol 194 (1) ◽  
pp. 112-117 ◽  
Author(s):  
Anna Mikulowska ◽  
Gregory G. Johnson ◽  
John M. Berberian ◽  
Eugene C. Butcher ◽  
Leslie M. McEvoy ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Salivary Gland ◽  
Pancreatic Islet ◽  
Lacrimal Gland ◽  
Adoptive Transfer ◽  
Scid Mice

Lacrimal and Salivary Gland Inflammation in the C3H/lpr Autoimmune Strain Mouse: A Potential Mode for Sjögren's Syndrome

1992 ◽  
Vol 106 (4) ◽  
pp. 394-399 ◽  
Author(s):  
Ilsa Schwartz ◽  
Bruce C. Johnson ◽  
Jane I. Morton ◽  
Dennis R. Trune
Keyword(s):  
Salivary Gland ◽  
Autoimmune Disease ◽  
Salivary Glands ◽  
Sjögren’S Syndrome ◽  
Lacrimal Gland ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Systemic Autoimmune Disease ◽  
Sjögren‘S Syndrome

Sjögren's syndrome is an autoimmune inflammatory disease that affects the lacrimal and salivary glands. To identify a potential animal model for study of Sjögren's syndrome, an evaluation was made of lacrimal and salivary glands in the C3H/ lpr autoimmune strain mouse at ages before (2 months) and after (5 months) systemic autoimmune disease onset at 3 to 4 months. Quantitative and qualitative analyses of, C3H/ lpr lacrimal and salivary (parotid, submandibular, and sublingual) gland histopathology were performed using age-matched C3H/HeJ nonautoimmune mice to control for inflammation of nonautoimmune origin. No lacrimal or salivary gland inflammation was seen in either of the strains at 2 months of age and measures of systemic autoimmune disease were negative. At 5 months of age, the nonautoimmune C3H/HeJ controls showed a slight increase in lacrimal gland inflammation, but this was not significantly different from the 2 month old controls. A significant increase in lacrimal gland inflammation was found in the 5 month old C3H/ lpr autoimmune mice in a histologic pattern similar to that of Sjögren's syndrome in human beings. Furthermore, the degree of inflammation was positively correlated with serum immune complexes and spleen weight. Sporadic inflammation of the submandibular gland was seen in both autoimmune and control mice, but this was neither statistically significant nor correlated with measures of autoimmunity. No significant inflammation was seen in the parotid or sublingual glands.

scholarly journals Adenoid cystic carcinomas of the salivary gland, lacrimal gland, and breast are morphologically and genetically similar but have distinct microRNA expression profiles

2018 ◽  
Vol 31 (8) ◽  
pp. 1211-1225 ◽  
Author(s):  
Simon Andreasen ◽  
Qihua Tan ◽  
Tina Klitmøller Agander ◽  
Petr Steiner ◽  
Kristine Bjørndal ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Lacrimal Gland ◽  
Expression Profiles ◽  
Microrna Expression ◽  
Adenoid Cystic

Changes in the 7th Edition of the AJCC TNM Classification and Recommendations for Pathologic Analysis of Lacrimal Gland Tumors

2009 ◽  
Vol 133 (8) ◽  
pp. 1268-1271 ◽  
Author(s):  
Jack Rootman ◽  
Valerie A. White
Keyword(s):  
Salivary Gland ◽  
Recent Work ◽  
Lacrimal Gland ◽  
Tnm Classification ◽  
Staging System ◽  
Cancer Staging ◽  
7Th Edition ◽  
Data Points ◽  
Pathologic Analysis

Abstract In our recent work to update the American Joint Committee on Cancer's AJCC Cancer Staging Manual, we brought the staging system in line with that of salivary gland malignancies to better describe the range of these tumors. In addition, we have suggested that information be collected on biomarkers and clinical and histologic data points. This revised staging, along with careful histologic analysis and patient follow-up, may provide information that helps develop more targeted management for these lesions.

scholarly journals Papillary-Cystic Variant of Acinic Cell Carcinoma in the Lacrimal Gland

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
Miles Bannister ◽  
Greig Lawson
Keyword(s):  
Salivary Gland ◽  
Cell Carcinoma ◽  
Lacrimal Gland ◽  
Acinic Cell Carcinoma ◽  
Tissue Type ◽  
Rare Tumour ◽  
Acinic Cell ◽  
Salivary Gland Tissue ◽  
First Case ◽  
Gland Tissue

Papillary-cystic variant of acinic cell carcinoma is a rare tumour confined to salivary gland tissue. Here, we report the first case ever to manifest in a tumour affecting the lacrimal gland, a completely different tissue type, and review the current published literature on this type of tumour.

Endotoxin Alteration of the Mucopolysaccharide Blood Vessel Coating in Rats

1974 ◽  
Vol 32 ◽  
pp. 148-149
Author(s):  
D. E. Philpott ◽  
A. Takahashi
Keyword(s):  
Skeletal Muscle ◽  
Endothelial Cells ◽  
Salivary Gland ◽  
Carotid Artery ◽  
Basement Membrane ◽  
Coronary Vessels ◽  
Ruthenium Red ◽  
E Coli ◽  
Old Rats ◽  
The Brain

Two month, eight month and two year old rats were treated with 10 or 20 mg/kg of E. Coli endotoxin I. P. The eight month old rats proved most resistant to the endotoxin. During fixation the aorta, carotid artery, basil arartery of the brain, coronary vessels of the heart, inner surfaces of the heart chambers, heart and skeletal muscle, lung, liver, kidney, spleen, brain, retina, trachae, intestine, salivary gland, adrenal gland and gingiva were treated with ruthenium red or alcian blue to preserve the mucopolysaccharide (MPS) coating. Five, 8 and 24 hrs of endotoxin treatment produced increasingly marked capillary damage, disappearance of the MPS coating, edema, destruction of endothelial cells and damage to the basement membrane in the liver, kidney and lung.

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