Cell Competition: The Struggle for Existence in Multicellular Communities

2014 ◽  
pp. 27-40
Author(s):  
Kei Kunimasa ◽  
Shizue Ohsawa ◽  
Tatsushi Igaki
Keyword(s):  
Cell Competition

Activin A resistant fetal liver stem/progenitor cells (FLSPC) vigorously repopulate aging rat liver through augmented cell competition

2011 ◽  
Vol 49 (01) ◽  
Author(s):  
A Menthena ◽  
CI Koehler ◽  
JS Sandhu ◽  
MI Yovchev ◽  
E Hurston ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Rat Liver ◽  
Fetal Liver ◽  
Activin A ◽  
Cell Competition ◽  
Aging Rat

Cell Competition: Roles and Importance as a Central Phenomenon

2015 ◽  
Vol 25 (4) ◽  
pp. 307-314
Author(s):  
Manish Patel ◽  
Bhavesh Antala ◽  
Neeta Shrivastava
Keyword(s):  
Cell Competition

scholarly journals Cell Fitness: More Than Push-Ups

2021 ◽  
Vol 22 (2) ◽  
pp. 518
Author(s):  
Adam James Ferrari ◽  
Ronny Drapkin ◽  
Rajan Gogna
Keyword(s):  
Cancer Progression ◽  
Hippo Pathway ◽  
Cancer Therapeutics ◽  
Protein Isoforms ◽  
Cell Junction ◽  
Cell Competition ◽  
Molecular Features ◽  
Oncogenic Pathways ◽  
Diagnostic Potential ◽  
The Impact

Cell competition (CC) is a feature that allows tumor cells to outcompete and eliminate adjacent cells that are deemed less fit. Studies of CC, first described in Drosophila melanogaster, reveal a diversity of underlying mechanisms. In this review, we will discuss three recent studies that expand our understanding of the molecular features governing CC. In particular, we will focus on a molecular fitness fingerprint, oncogenic pathways, and the importance of cell junction stability. A fitness fingerprint, mediated by flower (hFWE) protein isoforms, dictates that cells expressing the flower-win isoforms will outcompete adjacent flower-loss-expressing cells. The impact of the flower protein isoforms is seen in cancer progression and may have diagnostic potential. The yes-associated protein (YAP) and TAZ transcription factors, central mediators of the oncogenic Hippo pathway, elevate peritumoral fitness thereby protecting against tumor progression and provide a suppressive barrier. Similarly, COL17A1 is a key component in hemidesmosome stability, and its expression in epidermal stem cells contributes to fitness competition and aging characteristics. The contributions of these pathways to disease development and progression will help define how CC is hijacked to favor cancer growth. Understanding these features will also help frame the diagnostic and therapeutic possibilities that may place CC in the crosshairs of cancer therapeutics.

scholarly journals FGF21 Induced by the ASK1-p38 Pathway Promotes Mechanical Cell Competition by Attracting Cells

2020 ◽  
Author(s):  
Motoyuki Ogawa ◽  
Yosuke Kawarazaki ◽  
Yasuyuki Fujita ◽  
Isao Naguro ◽  
Hidenori Ichijo
Keyword(s):  
Cell Competition ◽  
P38 Pathway
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