Tensile Properties of Smooth Muscle Cells, Elastin, and Collagen Fibers

2016 ◽  
pp. 127-140 ◽  
Author(s):  
Takeo Matsumoto ◽  
Shukei Sugita ◽  
Kazuaki Nagayama
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Tensile Properties ◽  
Muscle Cells ◽  
Collagen Fibers

scholarly journals Combination of histochemical analyses and micro-MRI reveals regional changes of the murine cervix in preparation for labor

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Antara Chatterjee ◽  
Rojan Saghian ◽  
Anna Dorogin ◽  
Lindsay S. Cahill ◽  
John G. Sled ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Diffusion Tensor ◽  
Ex Vivo ◽  
Muscle Cells ◽  
Pregnant Mouse ◽  
Collagen Fibers ◽  
Muscular Layer ◽  
Tissue Organization ◽  
Picrosirius Red

AbstractThe cervix is responsible for maintaining pregnancy, and its timely remodeling is essential for the proper delivery of a baby. Cervical insufficiency, or “weakness”, may lead to preterm birth, which causes infant morbidities and mortalities worldwide. We used a mouse model of pregnancy and term labor, to examine the cervical structure by histology (Masson Trichome and Picrosirius Red staining), immunohistochemistry (Hyaluronic Acid Binding Protein/HABP), and ex-vivo MRI (T2-weighted and diffusion tensor imaging), focusing on two regions of the cervix (i.e., endocervix and ectocervix). Our results show that mouse endocervix has a higher proportion of smooth muscle cells and collagen fibers per area, with more compact tissue structure, than the ectocervix. With advanced gestation, endocervical changes, indicative of impending delivery, are manifested in fewer smooth muscle cells, expansion of the extracellular space, and lower presence of collagen fibers. MRI detected three distinctive zones in pregnant mouse endocervix: (1) inner collagenous layer, (2) middle circular muscular layer, and (3) outer longitudinal muscular layer. Diffusion MRI images detected changes in tissue organization as gestation progressed suggesting the potential application of this technique to non-invasively monitor cervical changes that precede the onset of labor in women at risk for preterm delivery.

scholarly journals Tensile Properties of Contractile and Synthetic Vascular Smooth Muscle Cells.

2002 ◽  
Vol 45 (4) ◽  
pp. 870-879 ◽  
Author(s):  
Hiroshi MIYAZAKI ◽  
Yoshitaka HASEGAWA ◽  
Kozaburo HAYASHI
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Tensile Properties ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells

A Structure-Based Model of Arterial Remodeling in Response to Sustained Hypertension

2009 ◽  
Vol 131 (10) ◽  
Author(s):  
Alkiviadis Tsamis ◽  
Nikos Stergiopulos ◽  
Alexander Rachev
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Time Course ◽  
Arterial Compliance ◽  
Experimental Studies ◽  
Wall Stress ◽  
Muscle Cells ◽  
Collagen Fibers ◽  
Opening Angle ◽  
Arterial Remodeling

A novel structure-based mathematical model of arterial remodeling in response to a sustained increase in pressure is proposed. The model includes two major aspects of remodeling in a healthy matured vessel. First, the deviation of the wall stress and flow-induced shear stress from their normal physiological values drives the changes in the arterial geometry. Second, the new mass that is produced during remodeling results from an increase in the mass of smooth muscle cells and collagen fibers. The model additionally accounts for the effect of the average pulsatile strain on the recruitment of collagen fibers in load bearing. The model was used to simulate remodeling of a human thoracic aorta, and the results are in good agreement with previously published model predictions and experimental data. The model predicts that the total arterial volume rapidly increases during the early stages of remodeling and remains virtually constant thereafter, despite the continuing stress-driven geometrical remodeling. Moreover, the effects of a perfect or incomplete restoration of the arterial compliance on the remodeling outputs were analyzed. For instance, the model predicts that the pattern of the time course of the opening angle depends on the extent to which the average pulsatile strain is restored at the end of the remodeling process. Future experimental studies on the time course of compliance, opening angle, and mass fractions of collagen, elastin, and smooth muscle cells can validate and improve the introduced hypotheses of the model.

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