New Inotropic Agents for Treatment of Heart Failure

1989 ◽  
pp. 343-350
Author(s):  
Keitaro Hashimoto
Keyword(s):  
Heart Failure ◽  
Inotropic Agents

scholarly journals Novel Therapeutic Targets in Heart Failure: The Phospholipase Cβ1b–Shank3 Interface

2015 ◽  
Vol 7 ◽  
pp. CMT.S18480
Author(s):  
Elizabeth A. Woodcock ◽  
David R. Grubb
Keyword(s):  
Heart Failure ◽  
Protein Kinase ◽  
Inotropic Agents ◽  
Specific Enzyme ◽  
Pump Performance ◽  
New Class ◽  
Promising Target ◽  
Protein Kinase Cα ◽  
Myocyte Contractility ◽  
Contractile Performance

Inotropic agents are often used to improve the contractile performance of the failing myocardium, but this is often at a cost of increased myocardial ischemia and arrhythmia. Myocyte contractility depends on the release of Ca2+ from the sarcoplasmic reticulum, and this Ca2+ is subject to regulation by the phosphorylation status of phospholamban (PLN). Many currently used inotropic agents function by increasing the phosphorylation of PLN, but these also heighten the risk of ischemia. Another approach is to reduce the dephosphorylation of PLN, which can be achieved by inhibiting pathways upstream or downstream of the protein kinase Cα. Phospholipase Cβ1b is responsible for activating protein kinase Cα, and its activity is substantially heightened in failing myocardium. We propose phospholipase Cβ1b, a cardiac-specific enzyme, as a promising target for the development of a new class of inotropic agents. By reversing changes that accompany the transition to heart failure, it may be possible to provide well-tolerated improvement in pump performance.

New Positive Inotropic Agents in the Treatment of Congestive Heart Failure

1986 ◽  
Vol 314 (6) ◽  
pp. 349-358 ◽  
Author(s):  
Wilson S. Colucci ◽  
Richard F. Wright ◽  
Eugene Braunwald
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Inotropic Agents ◽  
Positive Inotropic Agents

scholarly journals The Role of Novel Inotropic Agents in the Treatment of Heart Failure

1986 ◽  
Vol 8 ◽  
pp. S47 ◽  
Author(s):  
Thierry H. LeJemtel ◽  
Gad Keren ◽  
David Reis ◽  
Edmund H. Sonnenblick
Keyword(s):  
Heart Failure ◽  
Inotropic Agents

scholarly journals Beta-blocker therapy influences the hemodynamic response to inotropic agents in patients with heart failure

2002 ◽  
Vol 40 (7) ◽  
pp. 1248-1258 ◽  
Author(s):  
Marco Metra ◽  
Savina Nodari ◽  
Antonio D’Aloia ◽  
Claudio Muneretto ◽  
Alastair D Robertson ◽  
...  
Keyword(s):  
Heart Failure ◽  
Beta Blocker ◽  
Hemodynamic Response ◽  
Inotropic Agents ◽  
Blocker Therapy ◽  
Beta Blocker Therapy ◽  
Patients With Heart Failure
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