Survival-Promoting Effect of Electrical Stimulation on Axotomized Retinal Ganglion Cells

2003 ◽  
pp. 156-159
Author(s):  
Tomomitsu Miyoshi ◽  
Takeshi Morimoto ◽  
Toru Yakura ◽  
Yuka Okazaki ◽  
Takuji Kurimoto ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Promoting Effect

Discharges of tectal neurons evoked by electrical stimulation of single retinal ganglion cells in frogs

1985 ◽  
Vol 16 (6) ◽  
pp. 641-646
Author(s):  
A. V. Kuras ◽  
N. P. Khusainovene
Keyword(s):  
Electrical Stimulation ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Tectal Neurons ◽  
Stimulation Of

Discrimination of simple objects decoded from the output of retinal ganglion cells upon sinusoidal electrical stimulation

2021 ◽  
Author(s):  
Andrea Corna ◽  
Poornima Ramesh ◽  
Florian Jetter ◽  
Meng-Jung Lee ◽  
Jakob H. Macke ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion

scholarly journals Loss of Responses to Visual But Not Electrical Stimulation in Ganglion Cells of Rats With Severe Photoreceptor Degeneration

2009 ◽  
Vol 102 (6) ◽  
pp. 3260-3269 ◽  
Author(s):  
Chris Sekirnjak ◽  
Clare Hulse ◽  
Lauren H. Jepson ◽  
Pawel Hottowy ◽  
Alexander Sher ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Retinal Ganglion Cells ◽  
Vision Loss ◽  
Ganglion Cells ◽  
Transgenic Rat ◽  
Direct Electrical Stimulation ◽  
Retinal Ganglion ◽  
Photoreceptor Degeneration ◽  
Wild Type ◽  
Light Responses

Retinal implants are intended to help patients with degenerative conditions by electrically stimulating surviving cells to produce artificial vision. However, little is known about how individual retinal ganglion cells respond to direct electrical stimulation in degenerating retina. Here we used a transgenic rat model to characterize ganglion cell responses to light and electrical stimulation during photoreceptor degeneration. Retinas from pigmented P23H-1 rats were compared with wild-type retinas between ages P37 and P752. During degeneration, retinal thickness declined by 50%, largely as a consequence of photoreceptor loss. Spontaneous electrical activity in retinal ganglion cells initially increased two- to threefold, but returned to nearly normal levels around P600. A profound decrease in the number of light-responsive ganglion cells was observed during degeneration, culminating in retinas without detectable light responses by P550. Ganglion cells from transgenic and wild-type animals were targeted for focal electrical stimulation using multielectrode arrays with electrode diameters of ∼10 microns. Ganglion cells were stimulated directly and the success rate of stimulation in both groups was 60–70% at all ages. Surprisingly, thresholds (∼0.05 mC/cm2) and latencies (∼0.25 ms) in P23H rat ganglion cells were comparable to those in wild-type ganglion cells at all ages and showed no change over time. Thus ganglion cells in P23H rats respond normally to direct electrical stimulation despite severe photoreceptor degeneration and complete loss of light responses. These findings suggest that high-resolution epiretinal prosthetic devices may be effective in treating vision loss resulting from photoreceptor degeneration.

Parameters of optic nerve electrical stimulation affecting neuroprotection of axotomized retinal ganglion cells in adult rats

2008 ◽  
Vol 61 (2) ◽  
pp. 129-135 ◽  
Author(s):  
Yuka Okazaki ◽  
Takeshi Morimoto ◽  
Hajime Sawai
Keyword(s):  
Electrical Stimulation ◽  
Optic Nerve ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Adult Rats
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