Detecting a single defect in a scenery by observing the scenery along a random walk path

Author(s):  
Harry Kesten
2003 ◽  
Vol 125 (4) ◽  
pp. 539-577 ◽  
Author(s):  
Heinrich Matzinger ◽  
Silke W.W. Rolles

2004 ◽  
Vol 9 (0) ◽  
pp. 436-507 ◽  
Author(s):  
Matthias Loewe ◽  
Heinrich Matzinger ◽  
Franz Merkl

1996 ◽  
Vol 69 (1) ◽  
pp. 97-135 ◽  
Author(s):  
Itai Benjamini ◽  
Harry Kesten
Keyword(s):  

1995 ◽  
Vol 130 (6) ◽  
pp. 1239-1249 ◽  
Author(s):  
H Yokota ◽  
G van den Engh ◽  
J E Hearst ◽  
R K Sachs ◽  
B J Trask

We determined the folding of chromosomes in interphase nuclei by measuring the distance between points on the same chromosome. Over 25,000 measurements were made in G0/G1 nuclei between DNA sequences separated by 0.15-190 megabase pairs (Mbp) on three human chromosomes. The DNA sequences were specifically labeled by fluorescence in situ hybridization. The relationship between mean-square interphase distance and genomic separation has two linear phases, with a transition at approximately 2 Mbp. This biphasic relationship indicates the existence of two organizational levels at scales > 100 kbp. On one level, chromatin appears to be arranged in large loops several Mbp in size. Within each loop, chromatin is randomly folded. On the second level, specific loop-attachment sites are arranged to form a supple, backbonelike structure, which also shows characteristic random walk behavior. This random walk/giant loop model is the simplest model that fully describes the observed large-scale spatial relationships. Additional evidence for large loops comes from measurements among probes in Xq28, where interphase distance increases and then locally decreases with increasing genomic separation.


Author(s):  
Joseph Rudnick ◽  
George Gaspari
Keyword(s):  

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