Beyond Darwinism’s Eclipse: Functional Evolution, Biochemical Recapitulation and Spencerian Emergence in the 1920s and 1930s

2010 ◽  
pp. 119-140
Author(s):  
Rony Armon
Keyword(s):  
Functional Evolution

Functional Evolution of Plant CYCLOPROPYL STEROL ISOMERASE1 Gene

2014 ◽  
Vol 48 (4) ◽  
pp. 398-410
Author(s):  
Ma Xuemin ◽  
Sun Shuangli ◽  
Yang Hailing ◽  
Men Shuzhen
Keyword(s):  
Functional Evolution

Structural and Functional Evolution of the Translocator Protein (18 kDa)

2012 ◽  
Vol 12 (4) ◽  
pp. 369-386 ◽  
Author(s):  
J. Fan ◽  
P. Lindemann ◽  
M. G.J. Feuilloley ◽  
V. Papadopoulos
Keyword(s):  
Translocator Protein ◽  
Functional Evolution ◽  
Translocator Protein 18 Kda

Is ϝ-shaped digamma attested as a numerical sign in Greek papyri? Once more on P.Herc. 1669 and P.Oxy. 1176

2020 ◽  
Vol 140 ◽  
pp. 199-205
Author(s):  
Graziano Ranocchia
Keyword(s):  
Historical Evolution ◽  
Functional Evolution ◽  
Greek Alphabet

Abstract:T. Dorandi, who has previously proposed to read the book number included in the end-title of P.Herc. 1669 (Philodemus’ On Rhetoric) as a numerical ϝ-shaped digamma (= 6), has now advanced the same reading in the subscriptio of P.Oxy. 1176 (Satyrus, Lives book 6), where the editor princeps and all subsequent editors had unanimously read a stigma before. In this article, I argue not only that both readings are palaeographically untenable, but also that they historically contradict the graphic and functional evolution of digamma within the Greek alphabet. In particular, in both Graeco-Egyptian and Herculaneum papyri, ϝ-shaped digamma is always attested as a merely phonetic element (/w/ or waw) – never as a numeral symbol – whereas stigma, which represents the historical evolution of a variant of Archaic and Classical digamma, is the only form used as a numerical sign (= 6).

scholarly journals Putative ligand binding sites of two functionally characterized bark beetle odorant receptors

BMC Biology ◽  
2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Jothi K. Yuvaraj ◽  
Rebecca E. Roberts ◽  
Yonathan Sonntag ◽  
Xiao-Qing Hou ◽  
Ewald Grosse-Wilde ◽  
...  
Keyword(s):  
Ligand Binding ◽  
Bark Beetle ◽  
Pest Control ◽  
Binding Sites ◽  
Functional Characterization ◽  
Site Directed Mutagenesis ◽  
Odorant Receptors ◽  
Functional Evolution ◽  
General Importance ◽  
Insight Into

Abstract Background Bark beetles are major pests of conifer forests, and their behavior is primarily mediated via olfaction. Targeting the odorant receptors (ORs) may thus provide avenues towards improved pest control. Such an approach requires information on the function of ORs and their interactions with ligands, which is also essential for understanding the functional evolution of these receptors. Hence, we aimed to identify a high-quality complement of ORs from the destructive spruce bark beetle Ips typographus (Coleoptera, Curculionidae, Scolytinae) and analyze their antennal expression and phylogenetic relationships with ORs from other beetles. Using 68 biologically relevant test compounds, we next aimed to functionally characterize ecologically important ORs, using two systems for heterologous expression. Our final aim was to gain insight into the ligand-OR interaction of the functionally characterized ORs, using a combination of computational and experimental methods. Results We annotated 73 ORs from an antennal transcriptome of I. typographus and report the functional characterization of two ORs (ItypOR46 and ItypOR49), which are responsive to single enantiomers of the common bark beetle pheromone compounds ipsenol and ipsdienol, respectively. Their responses and antennal expression correlate with the specificities, localizations, and/or abundances of olfactory sensory neurons detecting these enantiomers. We use homology modeling and molecular docking to predict their binding sites. Our models reveal a likely binding cleft lined with residues that previously have been shown to affect the responses of insect ORs. Within this cleft, the active ligands are predicted to specifically interact with residues Tyr84 and Thr205 in ItypOR46. The suggested importance of these residues in the activation by ipsenol is experimentally supported through site-directed mutagenesis and functional testing, and hydrogen bonding appears key in pheromone binding. Conclusions The emerging insight into ligand binding in the two characterized ItypORs has a general importance for our understanding of the molecular and functional evolution of the insect OR gene family. Due to the ecological importance of the characterized receptors and widespread use of ipsenol and ipsdienol in bark beetle chemical communication, these ORs should be evaluated for their potential use in pest control and biosensors to detect bark beetle infestations.

Structural and functional evolution of group II intron ribozymes: Insights from unusual elements carrying a 3′ extension

2010 ◽  
Vol 27 (3) ◽  
pp. 204-211 ◽  
Author(s):  
Nicolas J. Tourasse ◽  
Fredrik B. Stabell ◽  
Anne-Brit Kolstø
Keyword(s):  
Group Ii Intron ◽  
Functional Evolution ◽  
Group Ii

Mechanism for the genomic and functional evolution of the miR2118 family in the grass lineage

2021 ◽  
Author(s):  
Ting Lan ◽  
Xiaoyu Yang ◽  
Jiwei Chen ◽  
Peng Tian ◽  
Lina Shi ◽  
...  
Keyword(s):  
Functional Evolution

Transcriptional repression, apoptosis, human disease and the functional evolution of the nuclear lamina

2001 ◽  
Vol 26 (1) ◽  
pp. 41-47 ◽  
Author(s):  
Merav Cohen ◽  
Yosef Gruenbaum ◽  
Kenneth K Lee ◽  
Katherine L Wilson
Keyword(s):  
Human Disease ◽  
Transcriptional Repression ◽  
Nuclear Lamina ◽  
Functional Evolution
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