Cell Fusion, Drug Resistance and Recurrence CSCs

2011 ◽  
pp. 173-182 ◽  
Author(s):  
Christa Nagler ◽  
Kurt S. Zänker ◽  
Thomas Dittmar
Keyword(s):  
Drug Resistance ◽  
Cell Fusion

Cell Fusion is a Potent Inducer of Aneuploidy and Drug Resistance in Tumor Cell/ Normal Cell Hybrids

2013 ◽  
Vol 18 (1 - 2) ◽  
pp. 97-113 ◽  
Author(s):  
Benjamin Berndt ◽  
Kurt S. Zanker ◽  
Thomas Dittmar
Keyword(s):  
Drug Resistance ◽  
Tumor Cell ◽  
Cell Fusion ◽  
Normal Cell ◽  
Potent Inducer ◽  
Cell Hybrids

scholarly journals Tumor Hybrid Cells: Nature and Biological Significance

2021 ◽  
Author(s):  
Maria S Tretyakova ◽  
Ayalur Raghu Subbalakshmi ◽  
Maxim E Menyailo ◽  
Mohit Kumar Jolly ◽  
Evgeny Denisov
Keyword(s):  
Drug Resistance ◽  
Tumor Cell ◽  
Cell Fusion ◽  
Cancer Metastasis ◽  
Experimental Studies ◽  
Biological Significance ◽  
Genetic Alterations ◽  
Clinicopathological Parameters ◽  
Cancer Drug ◽  
Hybrid Cells

Metastasis is the leading cause of cancer death and can be realized through the phenomenon of tumor cell fusion. The fusion of tumor cells with other tumor or normal cells leads to the appearance of tumor hybrid cells (THCs) exhibiting novel properties such as increased proliferation and migration, drug resistance, decreased apoptosis rate and avoiding immune surveillance. Experimental studies showed the association of THCs with a high frequency of cancer metastasis; however, the underlying mechanisms remain unclear. Many other questions also remain to be answered: the role of genetic alterations in tumor cell fusion, the molecular landscape of cells after fusion, the lifetime and fate of different THCs, and the specific markers of THCs, and their correlation with various cancers and clinicopathological parameters. In this review, we discuss the factors and potential mechanisms involved in the occurrence of THCs, the types of THCs, and their role in cancer drug resistance and metastasis, as well as potential therapeutic approaches for the prevention and targeting of tumor cell fusion. In conclusion, we emphasize the current knowledge gaps in the biology of THCs that should be addressed to develop highly effective therapeutics and strategies for metastasis suppression.

Polyploid Giant Cancer Cells (PGCCs): The Evil Roots of Cancer

2019 ◽  
Vol 19 (5) ◽  
pp. 360-367 ◽  
Author(s):  
Junsong Chen ◽  
Na Niu ◽  
Jing Zhang ◽  
Lisha Qi ◽  
Weiwei Shen ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Cancer Therapy ◽  
Cancer Cells ◽  
Cell Size ◽  
Cell Fusion ◽  
Human Embryo ◽  
Polyploid Giant Cancer Cells

Polyploidy is associated with increased cell size and is commonly found in a subset of adult organs and blastomere stage of the human embryo. The polyploidy is formed through endoreplication or cell fusion to support the specific need of development including earliest embryogenesis. Recent data demonstrated that Polyploid Giant Cancer Cells (PGCCs) may have acquired an activated early embryonic-like program in response to oncogenic and therapeutic stress to generate reprogrammed cancer cells for drug resistance and metastasis. Targeting PGCCs may open up new opportunities for cancer therapy.

Drug Resistance Factors Into HIV Treatment Failures

Ob Gyn News ◽  
2005 ◽  
Vol 40 (21) ◽  
pp. 45
Author(s):  
HEIDI SPLETE
Keyword(s):  
Drug Resistance ◽  
Hiv Treatment ◽  
Resistance Factors

Drug Resistance in Cancer

1998 ◽  
Author(s):  
James H. Goldie ◽  
Andrew J. Coldman
Keyword(s):  
Drug Resistance
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