Pathology: Histomorphometrical Features of IBC – Angiogenesis, Lymphangiogenesis, and Tumor Emboli

2012 ◽  
pp. 27-51
Author(s):  
Sanford H. Barsky ◽  
Fredika M. Robertson
Keyword(s):  
Tumor Emboli

scholarly journals Chylous Ascites, Unusual Association with Ductal Pancreatic Adenocarcinoma with Plasmacytoid Morphology: A Case Report and Literature Review

2021 ◽  
Vol 07 (03) ◽  
pp. e158-e162
Author(s):  
Catalin Bogdan Satala ◽  
Ioan Jung ◽  
Tivadar Jr. Bara ◽  
Vlad Tudorache ◽  
Simona Gurzu
Keyword(s):  
Pancreatic Cancer ◽  
Tumor Cells ◽  
Surgical Intervention ◽  
Chylous Ascites ◽  
Distal Portion ◽  
Ductal Adenocarcinoma ◽  
Lymph Vessels ◽  
Lymphangiosis Carcinomatosa ◽  
Ductal Pancreatic Adenocarcinoma ◽  
Tumor Emboli

AbstractChylous ascites represents a relatively uncommon condition. In this paper, we present a case of chyloperitoneum associated with pancreatic ductal adenocarcinoma (PDAC) and a review of literature regarding chylous ascites. A 76-year-old male patient was admitted in emergency department with acute abdomen. A pancreatic cancer was suspected. Subtotal spleno-pancreatectomy, for a nodular mass infiltrating the mild and distal portion of the pancreas, was necessary. During surgical intervention in the peritoneal cavity, a moderate quantity of whitish and thick consistency fluid with milk-like appearance was observed to be accumulated. After examination of the fluid, chyloperitoneum was diagnosed. The histologic examination showed a PDAC, with multiple emboli in lymph vessels, with tumor cells with plasmacytoid morphology, diagnosed as lymphangiosis carcinomatosa. The patient died at 3 weeks after surgical intervention. In patients with pancreatic cancer and chylous ascites, suspicion of tumor-related blockage of the lymphatic flow should be suspected. Prognosis of PDAC should be evaluated not only based on the number of lymph node metastases, but also considering the number of lymph vessels with tumor emboli and the architecture of tumor cells. This is the first reported case of a PDAC with plasmacytoid morphology of lymphangiosis carcinomatosa.

scholarly journals False-negative frozen section of sentinel nodes in early breast cancer (cT1-2N0) patients

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Zhu-Jun Loh ◽  
Kuo-Ting Lee ◽  
Ya-Ping Chen ◽  
Yao-Lung Kuo ◽  
Wei-Pang Chung ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Early Breast Cancer ◽  
False Negative ◽  
Disease Free Survival ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Frozen Sections ◽  
Sentinel Nodes ◽  
Tumor Emboli

Abstract Background Sentinel lymph node biopsy (SLNB) is the standard approach for the axillary region in early breast cancer patients with clinically negative nodes. The present study investigated patients with false-negative sentinel nodes in intraoperative frozen sections (FNSN) using real-world data. Methods A case–control study with a 1:3 ratio was conducted. FNSN was determined when sentinel nodes (SNs) were negative in frozen sections but positive for metastasis in formalin-fixed paraffin-embedded (FFPE) sections. The control was defined as having no metastasis of SNs in both frozen and FFPE sections. Results A total of 20 FNSN cases and 60 matched controls from 333 SLNB patients were enrolled between April 1, 2005, and November 31, 2009. The demographics and intrinsic subtypes of breast cancer were similar between the FNSN and control groups. The FNSN patients had larger tumor sizes on preoperative mammography (P = 0.033) and more lymphatic tumor emboli on core biopsy (P < 0.001). Four FNSN patients had metastasis in nonrelevant SNs. Another 16 FNSN patients had benign lymphoid hyperplasia of SNs in frozen sections and metastasis in the same SNs from FFPE sections. Micrometastasis was detected in seven of 16 patients, and metastases in nonrelevant SNs were recognized in two patients. All FNSN patients underwent a second operation with axillary lymph node dissection (ALND). After a median follow-up of 143 months, no FNSN patients developed breast cancer recurrence. The disease-free survival, breast cancer-specific survival, and overall survival in FNSN were not inferior to those in controls. Conclusions Patients with a larger tumor size and more lymphatic tumor emboli have a higher incidence of FNSN. However, the outcomes of FNSN patients after completing ALND were noninferior to those without SN metastasis. ALND provides a correct staging for patients with metastasis in nonsentinel axillary lymph nodes.

scholarly journals P37.10 PD-L1 Expression in Lymphovascular Tumor Emboli in Lung Adenocarcinoma

2021 ◽  
Vol 16 (3) ◽  
pp. S446
Author(s):  
Y. Yeh ◽  
H. Ma ◽  
H. Ho ◽  
T. Chou
Keyword(s):  
Lung Adenocarcinoma ◽  
Tumor Emboli

Tumor Emboli Presenting as Pulmonary Hypertension

CHEST Journal ◽  
1976 ◽  
Vol 69 (2) ◽  
pp. 229-230 ◽  
Author(s):  
James P. Graham ◽  
Harold H. Rotman ◽  
John G. Weg
Keyword(s):  
Pulmonary Hypertension ◽  
Tumor Emboli

SIR 2003 Film Panel Case 2: Tumor Emboli to the Common Iliac Arteries

2003 ◽  
Vol 14 (5) ◽  
pp. 656-658
Author(s):  
Danielle B. Leighton ◽  
Sun Ho Ahn ◽  
Timothy P. Murphy
Keyword(s):  
Iliac Arteries ◽  
The Common ◽  
Tumor Emboli ◽  
Common Iliac Arteries

Histopathological characterization of aortic intimal sarcoma with multiple tumor emboli

2000 ◽  
Vol 50 (11) ◽  
pp. 923-927 ◽  
Author(s):  
Naoki Nishida ◽  
Chikao Yutani ◽  
Hatsue Ishibashi-Ueda ◽  
Yoshitane Tsukamoto ◽  
Yoshihiko Ikeda ◽  
...  
Keyword(s):  
Intimal Sarcoma ◽  
Multiple Tumor ◽  
Tumor Emboli

scholarly journals Pulmonary micro-tumor emboli resulting in paradoxical emboli: a case report

2018 ◽  
Vol 8 (2) ◽  
pp. 204589321875485
Author(s):  
Louis-Vincent Morin-Thibault ◽  
Daniel Wiseman ◽  
Michelle Fortin ◽  
Christian Couture ◽  
Steeve Provencher
Keyword(s):  
Breast Cancer ◽  
Case Report ◽  
Tumor Cell ◽  
Pulmonary Vascular Resistance ◽  
Recurrent Breast Cancer ◽  
Pulmonary Tumor ◽  
Rare Manifestation ◽  
Paradoxical Emboli ◽  
Recurrent Breast ◽  
Tumor Emboli

Pulmonary tumor embolism (PTE) is a rare manifestation of cancer. It is characterized by the presence of tumor cell emboli in the pulmonary arterioles and capillaries leading to an elevation of pulmonary vascular resistance. The ante-mortem diagnosis is difficult. We report a case of PTE associated with recurrent breast cancer that presented with neurological symptoms due to paradoxical cerebral embolism.

scholarly journals False-Negative Frozen Section of Sentinel Nodes in Early Breast Cancer Patients

2021 ◽  
Author(s):  
Zhu-Jun Loh ◽  
Kuo-Ting Lee ◽  
Ya-Ping Chen ◽  
Yao-Lung Kuo ◽  
Wei-Pang Chung ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Cancer Patients ◽  
Frozen Section ◽  
False Negative ◽  
Axillary Lymph ◽  
Breast Cancer Patients ◽  
Frozen Sections ◽  
Sentinel Nodes ◽  
Tumor Emboli

Abstract Background: Sentinel lymph node biopsy (SLNB) is the standard approach of the axillary region for early breast cancer patients with clinically negative nodes. The present study investigated patients with false-negative sentinel nodes of intraoperative frozen section (FNSNs) in real-world data.Methods: A case–control study with a 1:3 ratio was conducted. FNSN was diagnosed when sentinel nodes (SNs) are negative in frozen sections but positive for metastasis in formalin-fixed paraffin-embedded (FFPE) sections. The control was defined as having no metastasis of SNs in both frozen and FFPE sections.Results: A total of 20 FNSN cases and 60 matched controls were enrolled from 333 SLNB patients between April 1, 2005, and November 31, 2009. The demographics and intrinsic subtypes of breast cancer were similar between FNSN and controls. The FNSN patients had larger tumor sizes in preoperative mammography (P = 0.033) and more lymphatic tumor emboli in core biopsy (P < 0.001). Four FNSN patients had metastasis in the non-relevant SNs. Another 16 FNSN patients had benign lymphoid hyperplasia of SNs in frozen sections and metastasis in the same SNs from the FFPE sections. Micrometastasis was detected in seven of 16 patients, and metastases in non-relevant SNs were recognized in two patients. All FNSN patients received a second operation with axillary lymph node dissection (ALND). After a median follow-up of 143 months, no FNSN patients developed recurrence of breast cancer. The disease-free survival, disease-specific survival, and overall survival in FNSN were not inferior to the controls.Conclusions: The patients with a larger tumor size and more lymphatic tumor emboli have a higher incidence of FNSN. However, outcomes of FNSN patients after completing ALND were noninferior to those without metastasis in SNs. ALND provides a correct diagnosis of patients with metastasis in non-sentinel axillary lymph nodes.

scholarly journals Removal of Tumor Emboli of Hepatocellular Carcinoma in the Portal Vein During Hepatectomy. A Successful Case.

1998 ◽  
Vol 31 (8) ◽  
pp. 1925-1929
Author(s):  
Yutaka Ozeki ◽  
Kenichiro Tateyama ◽  
Naoki Imai ◽  
Yasuhiro Sumi ◽  
Michiya Bando ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Portal Vein ◽  
Successful Case ◽  
Tumor Emboli

scholarly journals A Fatal Case of Hepatic Congestion and Necrosis Caused by Tumor Emboli in the Hepatic Veins Five Months after Curative Resection of Sigmoid Colon Cancer

2010 ◽  
Vol 43 (8) ◽  
pp. 844-849
Author(s):  
Yoshiyuki Mori ◽  
Hiroshi Iino ◽  
Masanori Matsuda ◽  
Tadashi Hyuga ◽  
Hirotaka Okamoto ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Sigmoid Colon ◽  
Curative Resection ◽  
Fatal Case ◽  
Sigmoid Colon Cancer ◽  
Hepatic Veins ◽  
Hepatic Congestion ◽  
Tumor Emboli
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