31-P-NMR Spectroscopy in vivo of Human and Rat Brain Tumors Grafted on Nude Mice

1987 ◽  
pp. 381-384
Author(s):  
C. Remy ◽  
J. P. Albrand ◽  
S. Lotito ◽  
M. Jacrot ◽  
A. François ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Brain Tumors ◽  
Rat Brain ◽  
Nude Mice

scholarly journals 1H-localized broadband13C NMR spectroscopy of the rat brain in vivo at 9.4 T

2003 ◽  
Vol 50 (4) ◽  
pp. 684-692 ◽  
Author(s):  
Pierre-Gilles Henry ◽  
Ivan Tkáč ◽  
Rolf Gruetter
Keyword(s):  
Nmr Spectroscopy ◽  
Rat Brain

In Vivo localized proton NMR spectroscopy of thiamine-deficient rat brain

1995 ◽  
Vol 34 (3) ◽  
pp. 313-318 ◽  
Author(s):  
Haakil Lee ◽  
James Tarter ◽  
George E. Holburn ◽  
Ronald R. Price ◽  
David D. Weinstein ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Rat Brain ◽  
Proton Nmr ◽  
Proton Nmr Spectroscopy

Quantification issues of in vivo 1 H NMR spectroscopy of the rat brain investigated at 16.4 T

2012 ◽  
Vol 26 (1) ◽  
pp. 74-82 ◽  
Author(s):  
Sung-Tak Hong ◽  
Rolf Pohmann
Keyword(s):  
Nmr Spectroscopy ◽  
Rat Brain ◽  
H Nmr

scholarly journals 1H NMR spectroscopy of rat brain in vivo at 14.1Tesla: Improvements in quantification of the neurochemical profile

2008 ◽  
Vol 194 (2) ◽  
pp. 163-168 ◽  
Author(s):  
Vladimír Mlynárik ◽  
Cristina Cudalbu ◽  
Lijing Xin ◽  
Rolf Gruetter
Keyword(s):  
Nmr Spectroscopy ◽  
Rat Brain ◽  
1H Nmr ◽  
1H Nmr Spectroscopy ◽  
Neurochemical Profile

scholarly journals Determination of Oxidative Glucose Metabolism In Vivo in the Young Rat Brain Using Localized Direct-Detected 13C NMR Spectroscopy

2011 ◽  
Vol 36 (11) ◽  
pp. 1962-1968 ◽  
Author(s):  
Kathleen Ennis ◽  
Dinesh Kumar Deelchand ◽  
Ivan Tkac ◽  
Pierre-Gilles Henry ◽  
Raghavendra Rao
Keyword(s):  
Nmr Spectroscopy ◽  
Glucose Metabolism ◽  
Rat Brain ◽  
13C Nmr ◽  
13C Nmr Spectroscopy ◽  
Young Rat

Isolation and preliminary characterization of ACNUresistant sublines of rat brain tumors in vivo

1992 ◽  
Vol 77 (3) ◽  
pp. 451-456 ◽  
Author(s):  
T. Ken Yoshida ◽  
Keiji Shimizu ◽  
Athanasios Koulousakis ◽  
Volker Sturm ◽  
Emile Beuls
Keyword(s):  
Brain Tumors ◽  
Rat Brain ◽  
Cell Lines ◽  
Resistant Cell ◽  
Chemotherapeutic Agents ◽  
Cross Resistance ◽  
Chemical Structures ◽  
Wide Range

✓ Two variant cells lines resistant to the nitrosourea derivative ACNU ((1-4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride), namely C6/ACNU and 9L/ACNU, were selected in vivo from rat brain tumors. Stable resistance to ACNU proved to be a characteristic of these cell lines, whether they were grown in vivo or in vitro. These cell lines exhibited a different pattern of cross-resistance to a wide range of chemotherapeutic agents with dissimilar chemical structures and mechanisms of action as compared with that of other ACNU-resistant cell lines established in vitro. Distinct cross-resistance was observed in both the C6/ACNU and 9L/ACNU cell lines to chloroethyl-nitrosoureas such as BCNU (carmustine), CCNU (lomustine), and methyl CCNU and, additionally, to vincristine, vinblastine, Adriamycin (doxorubicin), and arabinosylcytosine, but not to bleomycin, methotrexate, c/s-platinum, and 5-fluorouracil. This might point to a multifactorial mechanism of drug resistance in ACNU-resistant cell lines derived from rat C6 and 9L brain tumor cells.

Sign in / Sign up

Export Citation Format

Share Document