Irregular Menstrual Cycles During Aid: Use of Synthetic LH-RH and its Analogs for Timing of Ovulation

1982 ◽  
pp. 133-139
Author(s):  
Thomas Katzorke
Keyword(s):  
Menstrual Cycles ◽  
Lh Rh

EFFECTS OF CIMETIDINE ON PROLACTIN, LH, AND SEX STEROID SECRETION IN MALE AND FEMALE VOLUNTEERS

1978 ◽  
Vol 88 (3) ◽  
pp. 428-434 ◽  
Author(s):  
H. G. Bohnet ◽  
M. Greiwe ◽  
J. P. Hanker ◽  
C. Aragona ◽  
H. P. G. Schneider
Keyword(s):  
Bolus Injection ◽  
Elevated Serum ◽  
Follicular Phase ◽  
Sex Steroid ◽  
Similar Extent ◽  
Duodenal Ulcers ◽  
Male And Female ◽  
Steroid Secretion ◽  
Menstrual Cycles ◽  
Lh Rh

ABSTRACT The histamine H2-receptor antagonist cimetidine, which has recently been introduced for the treatment of gastric and duodenal ulcers and haemorrhage, respectively, stimulates prolactin (PRL) secretion. The release of PRL after a bolus injection of the compound is significantly higher in female than in male volunteers, and is more pronounced during the luteal than during the follicular phase of the menstrual cycle. Oral administration of the drug stimulates PRL to a similar extent as parenteral administration. Treatment of male and female volunteers with cimetidine for 20 days (1 g/day orally) resulted in elevated serum PRL concentrations in both sexes. Basal LH levels as well as the response to 25 μg LH-RH were not significantly changed after treatment. Testosterone levels in males and oestradiol levels in females were not altered. Luteal progesterone, however, was significantly diminished in the menstrual cycles when cimetidine was given. The mechanism underlying the stimulatory effect of cimetidine on PRL secretion is not clear, but it does not seem that this ability is exerted via an inhibition of pituitary dopamine receptors. The dopaminergic effect of lisuride, an ergot alkaloid, could not be reversed by cimetidine.

Leuprorelinimplantat in der Routineanwendung: Wirksam, sicher und wirtschaftlich

2010 ◽  
Vol 01 (03) ◽  
pp. 139-140
Author(s):  
Luise Mansel
Keyword(s):  
Lh Rh

Mehr als drei Viertel der Prostata-Karzinome sind Testosteron-sensitiv und wachsen primär hormonabhängig. Daher besteht die Standardtherapie in einer Behandlung mit LH-RH-Analoga (synthetische Gonadotropin-Releasing-Hormon-Analoga). Dabei kommt es durch pharmakologische Absenkung des Serumtestosteronspiegels auf Kastrationsniveau (<50 ng/dl) zur Verringerung der Tumorgröße oder zumWachstumsstillstand. Gegenüber der operativen Kastration hat die medikamentöse Hormonsenkung den Vorteil der Reversibilität.

LH-RH TEST IN 100 PATIENTS WITH OVARIAN INSUFFICIENCY

1974 ◽  
Vol 75 (3) ◽  
pp. 428-434 ◽  
Author(s):  
P.-J. Czygan ◽  
M. Breckwoldt ◽  
F. Lehmann ◽  
R. Langefeld ◽  
G. Bettendorf
Keyword(s):  
Intravenous Injection ◽  
Functional State ◽  
Clear Correlation ◽  
Normal Range ◽  
Ovarian Insufficiency ◽  
Lh Rh ◽  
Dose Dependent Increase ◽  
Dose Dependent

ABSTRACT The effect of synthetic LH-RH was studied in 100 patients with various types of ovarian insufficiency by following up the FSH- and LH-levels in plasma. LH-RH was administered in doses of 12.5, 25 and 100 μg as a rapid intravenous injection. The patients were classified according to the endocrine state of the pituitary as evidenced by the urinary gonadotrophin levels. A clear correlation between the functional state of the pituitary and its responsiveness to exogenous LH-RH was demonstrated. Most of the patients with undetectable low urinary gonadotrophin levels failed to respond. The majority of patients with gonadotrophin excretion in the normal range and those with elevated levels reacted with a dose dependent increase in circulating LH. The amount of liberated FSH however was related to the injected dose only in patients with high gonadotrophic excretion. The present study indicates that synthetic LH-RH provides a useful tool in the evaluation of the pitutiary function particularly in patients with low and with undetectable gonadotrophin excretion. The data presented in this paper also demonstrate that the functional state of the pituitary is clearly reflected by the urinary gonadotrophin levels.

ISOLATION AND CHARACTERIZATION OF TWO DIFFERENT PORCINE HYPOTHALAMIC PREPARATIONS WITH LH-RH-LIKE ACTIVITY AND THEIR COMPARISON WITH SYNTHETIC LH-RH

1972 ◽  
Vol 68 (3_Suppl) ◽  
pp. S53
Author(s):  
F. Enzmann ◽  
K. Geisen ◽  
R. Geiger ◽  
W. König ◽  
H. Wissmann
Keyword(s):  
Isolation And Characterization ◽  
Lh Rh

INTERACTION OF PROSTAGLANDINS AND LH-RH IN VITRO

1973 ◽  
Vol 71 (4_Suppl) ◽  
pp. S81
Author(s):  
M. Babej ◽  
J. Sandow ◽  
E. Kircher
Keyword(s):  
Lh Rh

EFFECT OF LH-RH ON SERUM FSH, LH AND PROGESTERONE DURING THE LUTEAL PHASE OF THE MENSTRUAL CYCLE

1975 ◽  
Vol 80 (1_Suppla) ◽  
pp. S20
Author(s):  
I. Gerhard ◽  
M. Röhrich ◽  
K. Klinga ◽  
B. Runnebaum
Keyword(s):  
Menstrual Cycle ◽  
Luteal Phase ◽  
Lh Rh

Effects of oestradiol on sex hormone binding globulin

1982 ◽  
Vol 101 (2) ◽  
pp. 248-253 ◽  
Author(s):  
Viveca Odlind ◽  
Kerstin Elamsson ◽  
Doris E. Englund ◽  
Arne Victor ◽  
Elof D. B. Johansson
Keyword(s):  
Luteal Phase ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Pronounced Increase ◽  
Menstrual Cycles ◽  
Menopausal Women ◽  
Plasma Oestradiol

Abstract. Sex hormone binding globulin (SHBG) levels were studied for possible effects of oestradiol-17β on SHBG. No change in SHBG plasma was recorded during normal menstrual cycles or during treatment with oestradiol-17β to menopausal women. However, gonadotrophin treatment to amenorrhoeic women to induce ovulation resulted in high oestradiol concentrations and a pronounced increase in SHBG was found during the luteal phase of these cycles. A marked increase of SHBG was also recorded in a woman with pronounced fluctuations of oestradiol during treatment with levonorgestrel sc implants for contraception. In conclusion, effects on SHBG were only found when extraordinarily high levels of plasma oestradiol were recorded.

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