Design and Synthesis of an Amide-Linked Angiotensin II Analogue with 3,5 Side Chain Bridge: Structural Resemblance of Ring Cluster Conformation with AT1 Non-Peptide Antagonists

2001 ◽  
pp. 656-657
Author(s):  
Panagiota Roumelioti ◽  
Ludmila Polevaya ◽  
Nektarios Giatas ◽  
Anastasia Zoga ◽  
Ilze Mutule ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Side Chain ◽  
Design And Synthesis ◽  
Structural Resemblance

Polymers from coumarins, 2. Design and synthesis of novel main- and side-chain coumarin-containing polymers

1997 ◽  
Vol 198 (5) ◽  
pp. 1679-1689 ◽  
Author(s):  
Sergei Fomine ◽  
Heriberto Pérez ◽  
Lioudmila Fomina ◽  
Mikhail Tlenkopatchev ◽  
Takeshi Ogawa
Keyword(s):  
Side Chain ◽  
Design And Synthesis

Halogenation Enhances the Photosystem II Inhibitory Activity of 4-Hydroxypyridines: Structure-Activity Relationships and Their Mode of Action

1993 ◽  
Vol 48 (3-4) ◽  
pp. 152-158 ◽  
Author(s):  
Tadao Asami ◽  
Masatoshi Baba ◽  
Hiroyuki Koike ◽  
Yorinao Inoue ◽  
Shigeo Yoshida
Keyword(s):  
Photosystem Ii ◽  
Mode Of Action ◽  
Phenyl Ring ◽  
Pyridine Ring ◽  
Functional Group ◽  
Photosynthetic Electron Transport ◽  
Cross Resistance ◽  
Side Chain ◽  
Structural Resemblance ◽  
Structure Activity

Abstract A range of 4-hydroxypyridines were synthesized and their activity as PET inhibitors were investigated with regard to their structural resemblance to plastoquinone in photosynthetic electron transport (PET). The activity of these compounds was markedly enhanced upon modifying their structures: introduction of halogens into both the 3-and 5-positions of the pyridine ring and additional substitution at the α-position of the side chain at 6-position were effective among others in enhancing the activity. Insertion of a phenyl ring into the side chain at 6-position of the pyridine ring also increased the activity. Substituents on the phenyl ring greatly affected the activity: when substituted with an appropriate functional group, the compounds became 10-to 100-fold more active. The mode of action of both halogenated and non-halogenated 4-hydroxypyridines were investigated by means of thermoluminescence measurements and cross resistance examination against atrazine-resistant thylakoids having mutation in D 1 protein. It was inferred that upon halogenation, 4-hydroxypyridines changed their mode of action from plastoquinone-pool inhibitors to phenol-type inhibitors.

The design and synthesis of a potent angiotensin II cyclic analogue confirms the ring cluster receptor conformation of the hormone angiotensin II

2000 ◽  
Vol 8 (1) ◽  
pp. 1-10 ◽  
Author(s):  
John M. Matsoukas ◽  
Ludmila Polevaya ◽  
Juris Ancans ◽  
Thomas Mavromoustakos ◽  
Antonios Kolocouris ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Design And Synthesis ◽  
Receptor Conformation

Side-Chain Substitutions within Angiotensin II Reveal Different Requirements for Signaling, Internalization, and Phosphorylation of Type 1A Angiotensin Receptors

2002 ◽  
Vol 61 (4) ◽  
pp. 768-777 ◽  
Author(s):  
Alice C. Holloway ◽  
Hongwei Qian ◽  
Luisa Pipolo ◽  
James Ziogas ◽  
Shin-ichiro Miura ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Angiotensin Receptors ◽  
Side Chain

Design, synthesis and biological evaluation of cyclic angiotensin II analogues with 3,5 side-Chain bridges

2002 ◽  
Vol 12 (18) ◽  
pp. 2627-2633 ◽  
Author(s):  
Panagiota Roumelioti ◽  
Ludmila Polevaya ◽  
Panagiotis Zoumpoulakis ◽  
Nektarios Giatas ◽  
Ilze Mutule ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Biological Evaluation ◽  
Side Chain ◽  
Design Synthesis ◽  
Angiotensin Ii Analogues ◽  
Synthesis And Biological Evaluation
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