Effect of Aminoguanidine on Induced-diabetic Rabbits and Diabetic Patients with ESRD

Author(s):  
Clinton D. Brown ◽  
Zhong Zhao ◽  
Loraine Thomas ◽  
Eli A. Friedman
1954 ◽  
Vol 30 (4) ◽  
pp. 230-233,262
Author(s):  
Fumio OSAKA ◽  
Hisashi TAKADA ◽  
Yoshiki UENO ◽  
Tadashi TAKAMOTO

2019 ◽  
pp. 27-30

VARIACIÓN DE LA VISCOSIDAD PLASMÁTICA EN CONEJOS INDUCIDOS A UNA DIABETES ALOXÁNICA VARIATION OF PLASMATIC VISCOSITY IN ALLOXAN-INDUCED DIABETIC RABBITS Gonzales Medrano, M. Fernando, Infantas Mesías, Delia y Sam Torres, Rosa DOI: https://doi.org/10.33017/RevECIPeru2009.0006/ RESUMEN Se investigó la variación de la viscosidad plasmática en conejos inducidos a una diabetes aloxánica. Adicionalmente, los valores de hematocrito, densidad plasmática y deformabilidad celular de glóbulos rojos fueron estimados. Los animales diabéticos presentaron pérdida de peso mientras que la densidad y viscosidad plasmática se incrementaron. Los valores de hematocrito no mostraron diferencias estadísticas significativas. Estos resultados sugieren que el incremento del valor de la viscosidad plasmática es un factor involucrado en la viscosidad sanguínea descrita para pacientes diabéticos con descompensación. Palabras clave: Viscosidad plasmática, diabetes aloxánica, conejos. ABSTRACT The variation of plasmatic viscosity in alloxan-induced diabetic rabbits was investigated. Additionally, hematocrit values, plasmatic density and red blood cell deformability were estimated. The diabetic animals showed loss weight whereas the density and viscosity of plasma were increased. The Hematocrit values did not show any significative statistical differences. These results suggest the increased level of plasmatic viscosity is an involucrated factor in the blood viscosity described for decompensated diabetic patients. Keywords: Plasmatic viscosity, alloxan-diabetes, rabbits.


Author(s):  
Bruce R. Pachter

Diabetes mellitus is one of the commonest causes of neuropathy. Diabetic neuropathy is a heterogeneous group of neuropathic disorders to which patients with diabetes mellitus are susceptible; more than one kind of neuropathy can frequently occur in the same individual. Abnormalities are also known to occur in nearly every anatomic subdivision of the eye in diabetic patients. Oculomotor palsy appears to be common in diabetes mellitus for their occurrence in isolation to suggest diabetes. Nerves to the external ocular muscles are most commonly affected, particularly the oculomotor or third cranial nerve. The third nerve palsy of diabetes is characteristic, being of sudden onset, accompanied by orbital and retro-orbital pain, often associated with complete involvement of the external ocular muscles innervated by the nerve. While the human and experimental animal literature is replete with studies on the peripheral nerves in diabetes mellitus, there is but a paucity of reported studies dealing with the oculomotor nerves and their associated extraocular muscles (EOMs).


Author(s):  
John M. Basgen ◽  
Eileen N. Ellis ◽  
S. Michael Mauer ◽  
Michael W. Steffes

To determine the efficiency of methods of quantitation of the volume density of components within kidney biopsies, techniques involving a semi-automatic digitizing tablet and stereological point counting were compared.Volume density (Vv) is a parameter reflecting the volume of a component to the volume that contains the component, e.g., the fraction of cell volume that is made up of mitochondrial volume. The units of Vv are μm3 /μm3.Kidney biopsies from 15 patients were used. Five were donor biopsies performed at the time of kidney transplantation (patients 1-5, TABLE 1) and were considered normal kidney tissue. The remaining biopsies were obtained from diabetic patients with a spectrum of diabetic kidney lesions. The biopsy specimens were fixed and embedded according to routine electron microscogy protocols. Three glomeruli from each patient were selected randomly for electron microscopy. An average of 12 unbiased and systematic micrographs were obtained from each glomerulus and printed at a final magnification of x18,000.


2008 ◽  
Vol 42 (10) ◽  
pp. 34
Author(s):  
BRUCE JANCIN

1999 ◽  
Vol 1 ◽  
pp. S55-S55
Author(s):  
D BOUMAL ◽  
Y BERNARD ◽  
A SABBAH ◽  
C ZIMMERMANN ◽  
A PENFORNIS ◽  
...  

2006 ◽  
Vol 12 ◽  
pp. 9
Author(s):  
David S. Oyer ◽  
Ajul Shah

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