Review of international recommendations on animal toxicity studies and their relation to clinical exposure

1994 ◽  
pp. 17-25 ◽  
Author(s):  
David Scales ◽  
Toshimi Usui
Keyword(s):  
Clinical Exposure ◽  
Toxicity Studies ◽  
Animal Toxicity

scholarly journals Characterization of an Expectorant Herbal Basak Tea Prepared with Adhatoda vasica Leaves

1970 ◽  
Vol 44 (2) ◽  
pp. 211-214 ◽  
Author(s):  
Ashish K Sarker ◽  
Kabir Ahamed ◽  
Jasim Uddin Chowdhury ◽  
Jarifa Begum
Keyword(s):  
Petroleum Ether Extract ◽  
Analytical Data ◽  
Water Extract ◽  
Relaxation Effect ◽  
Hot Water ◽  
Herbal Tea ◽  
Adhatoda Vasica ◽  
Alcohol Extract ◽  
Toxicity Studies ◽  
Animal Toxicity

A herbal tea for an expectorant action was prepared with Adhatoda vasica leaves. Analytical, pharmacological, microbiological and animal toxicity studies were carried out to characterize the herbal tea. The analytical data indicates that the alcohol extract from herbal basak tea contains 0.67% crude alkaloids and the isolated tracheal chain experiment with this extract showed small relaxation effect compare to the standard histamine drug. The crude alkaloids and the other extracts (petroleum ether extract, alcohol extract and hot water extract) showed mild inhibition in different degrees against different microorganisms. The animal toxicity studies on rats revealed no mortality after 24 hours and also no abnormal delayed effect indicates no toxicity of prepared tea at all. Based on the above results, the prepared herbal basak tea is proposed as a good expectorant. Herbal tea prepared with Adhatoda vasica leaves collected in May to September showed better efficacy than those of other times. Key words: Herbal basak tea, Crude alkaloids, Relaxation effect. DOI: 10.3329/bjsir.v44i2.3674 Bangladesh J. Sci. Ind. Res. 44(2), 211-214, 2009

The Computerization of Histopathological Data in Toxicological Laboratory Studies Using SNOP

1978 ◽  
Vol 17 (04) ◽  
pp. 272-279 ◽  
Author(s):  
D. C. Naylor
Keyword(s):  
Data Bank ◽  
Precise Definition ◽  
Laboratory Studies ◽  
Histopathological Findings ◽  
Storage And Retrieval ◽  
House Values ◽  
Toxicity Studies ◽  
Animal Toxicity ◽  
Improved Accuracy ◽  
Computerized System

A computerized system, based on the Systematized Nomenclature of Pathology (SNOP), for the recording, storage and retrieval of histopathological findings in animal toxicity studies, is described. The system is novel in that every diagnostic term used is given a precise definition agreed upon by the pathologists concerned, and which can be revised whenever necessary. It has resulted in standardization of terminology, greater speed in association with improved accuracy and presentation of reports, and the establishment of a data bank from which in-house values can be readily retrieved. Finally, it has led to an enormous saving hi the time of both pathologists and secretaries.

Animal toxicity studies with ammonium perfluorooctanoate

AIHAJ ◽  
1980 ◽  
Vol 41 (8) ◽  
pp. 576-583 ◽  
Author(s):  
F. D. GRIFFITH ◽  
J. E. LONG
Keyword(s):  
Toxicity Studies ◽  
Animal Toxicity

scholarly journals Toxic Effects of Cannabis and Cannabinoids: Animal Data

2005 ◽  
Vol 10 (suppl a) ◽  
pp. 23A-26A ◽  
Author(s):  
Pierre Beaulieu
Keyword(s):  
Acute Toxicity ◽  
Present Article ◽  
Chronic Toxicity ◽  
Toxic Effects ◽  
Acute Administration ◽  
Toxicity Data ◽  
Toxicity Studies ◽  
Animal Data ◽  
Animal Toxicity

The present article reviews the main toxic effects of cannabis and cannabinoids in animals. Toxic effects can be separated into acute and chronic classifications. Acute toxicity studies show that it is virtually impossible to die from acute administration of marijuana or tetrahydrocannabinol, the main psychoactive component of cannabis. Chronic toxicity involves lesions of airway and lung tissues, as well as problems of neurotoxicity, tolerance and dependence, and dysregulations in the immune and hormonal systems. Animal toxicity data, however, are difficult to extrapolate to humans.

Pharmacokinetics in Chronic Animal Toxicity Studies

1982 ◽  
Vol 13 (6) ◽  
pp. 1021-1051 ◽  
Author(s):  
Avraham Yacobi ◽  
Burde L. Kamath ◽  
Chii-Ming Lai
Keyword(s):  
Toxicity Studies ◽  
Animal Toxicity

Characterizing the human equivalent dose of herbal medicines in animal toxicity studies

2015 ◽  
Vol 162 ◽  
pp. 1-6 ◽  
Author(s):  
Ji-Won Bae ◽  
Da-Hyun Kim ◽  
Wha-Won Lee ◽  
Hyo-Young Kim ◽  
Chang-Gue Son
Keyword(s):  
Herbal Medicines ◽  
Equivalent Dose ◽  
Toxicity Studies ◽  
Animal Toxicity
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