Compositional Correlations and Gene Distribution of the Human Genome

1999 ◽  
pp. 115-123
Author(s):  
Oliver Clay ◽  
Giuseppe D’Onofrio ◽  
Kamel Jabbari ◽  
Serguei Zoubak ◽  
Salvatore Saccone ◽  
...  
Keyword(s):  
Human Genome ◽  
Gene Distribution

Gene distribution and nucleotide sequence organization in the human genome

1986 ◽  
Vol 160 (3) ◽  
pp. 479-485 ◽  
Author(s):  
Marino ZERIAL ◽  
Julio SALINAS ◽  
Jan FILIPSKI ◽  
Giorgio BERNARDI
Keyword(s):  
Nucleotide Sequence ◽  
Human Genome ◽  
Gene Distribution ◽  
Sequence Organization

Heterogeneous gene distribution reflects human genome complexity as detected at the cytogenetic level

2002 ◽  
Vol 134 (2) ◽  
pp. 168-171 ◽  
Author(s):  
Antonio Musio ◽  
Tullio Mariani ◽  
Paolo Vezzoni ◽  
Annalisa Frattini
Keyword(s):  
Human Genome ◽  
Gene Distribution ◽  
Genome Complexity

The gene distribution of the human genome

Gene ◽  
1996 ◽  
Vol 174 (1) ◽  
pp. 95-102 ◽  
Author(s):  
Serguei Zoubak ◽  
Oliver Clay ◽  
Giorgio Bernardi
Keyword(s):  
Human Genome ◽  
Gene Distribution

Expression patterns and gene distribution in the human genome

Gene ◽  
2002 ◽  
Vol 300 (1-2) ◽  
pp. 155-160 ◽  
Author(s):  
Giuseppe D'Onofrio
Keyword(s):  
Human Genome ◽  
Expression Patterns ◽  
Gene Distribution

Gene Distribution in the Human Genome

2006 ◽  
Author(s):  
Yujing Zeng ◽  
Javier Garcia-Frias ◽  
Adam G. Marsh
Keyword(s):  
Human Genome ◽  
Gene Distribution

DNA methylation in satellite repeats disorders

2019 ◽  
Vol 63 (6) ◽  
pp. 757-771 ◽  
Author(s):  
Claire Francastel ◽  
Frédérique Magdinier
Keyword(s):  
Dna Methylation ◽  
Human Genome ◽  
Repetitive Dna ◽  
Dna Sequences ◽  
Satellite Repeats ◽  
Tremendous Progress ◽  
Genes Encoding ◽  
Dna Elements ◽  
Near Future

Abstract Despite the tremendous progress made in recent years in assembling the human genome, tandemly repeated DNA elements remain poorly characterized. These sequences account for the vast majority of methylated sites in the human genome and their methylated state is necessary for this repetitive DNA to function properly and to maintain genome integrity. Furthermore, recent advances highlight the emerging role of these sequences in regulating the functions of the human genome and its variability during evolution, among individuals, or in disease susceptibility. In addition, a number of inherited rare diseases are directly linked to the alteration of some of these repetitive DNA sequences, either through changes in the organization or size of the tandem repeat arrays or through mutations in genes encoding chromatin modifiers involved in the epigenetic regulation of these elements. Although largely overlooked so far in the functional annotation of the human genome, satellite elements play key roles in its architectural and topological organization. This includes functions as boundary elements delimitating functional domains or assembly of repressive nuclear compartments, with local or distal impact on gene expression. Thus, the consideration of satellite repeats organization and their associated epigenetic landmarks, including DNA methylation (DNAme), will become unavoidable in the near future to fully decipher human phenotypes and associated diseases.

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