De/colonial methodologies and ontoepistemologies have gained popularity in the academic discourses emerging from Global North perspectives over the last decade. However, such perspectives often erase the broader global agenda of de/colonizing research, praxis, and activism that could be initiated and engaged with beyond the issue of land repatriation, as that is not the only agenda in de/colonial initiatives. In this chapter, I coin a framework, Par/Des(i), with six tenets, and offer three actionable methodological turns grounded in transnational de/colonial ontoepistemologies. I locate, situate, and trace the Par/Des(i) framework within the South Asian diasporic discourses and lived realities as evidenced from my empirical work with transnational South Asian women, my community, and my colleagues. Therefore, I offer possibilities of being, knowing, and enacting de/colonizing methodologies in our work, when engaging with the Par/Des(i) framework, with an invitation for an expanded conversation.