Identification and validation of plasma biomarkers for diagnosis of breast cancer in South Asian women

Breast cancer is the most common malignancy among women globally. Development of a reliable plasma biomarker panel might serve as a non-invasive and cost-effective means for population-based screening of the disease. Transcriptomic profiling of breast tumour, paired normal and apparently normal tissues, followed by validation of the shortlisted genes using TaqMan® Low density arrays and Quantitative real-time PCR was performed in South Asian women. Fifteen candidate protein markers and 3 candidate epigenetic markers were validated first in primary breast tumours and then in plasma samples of cases [N = 202 invasive, 16 DCIS] and controls [N = 203 healthy, 37 benign] using antibody array and methylation specific PCR. Diagnostic efficiency of single and combined markers was assessed. Combination of 6 protein markers (Adipsin, Leptin, Syndecan-1, Basic fibroblast growth factor, Interleukin 17B and Dickopff-3) resulted in 65% sensitivity and 80% specificity in detecting breast cancer. Multivariate diagnostic analysis of methylation status of SOSTDC1, DACT2, WIF1 showed 100% sensitivity and up to 91% specificity in discriminating BC from benign and controls. Hence, combination of SOSTDC1, DACT2 and WIF1 was effective in differentiating breast cancer [non-invasive and invasive] from benign diseases of the breast and healthy individuals and could help as a complementary diagnostic tool for breast cancer.

Multicentre randomised controlled trial of a group psychological intervention for postnatal depression in British mothers of South Asian origin (ROSHNI-2): study protocol

Background In the UK, postnatal depression is more common in British South Asian women than White Caucasion women. Cognitive–behavioural therapy (CBT) is recommended as a first-line treatment, but there is little evidence for the adaptation of CBT for postnatal depression to ensure its applicability to different ethnic groups. Aims To evaluate the clinical and cost-effectiveness of a CBT-based positive health programme group intervention in British South Asian women with postnatal depression. Method We have designed a multicentre, two-arm, partially nested, randomised controlled trial with 4- and 12-month follow-up, comparing a 12-session group CBT-based intervention (positive health programme) plus treatment as usual with treatment as usual alone, for British South Asian women with postnatal depression. Participants will be recruited from primary care and appropriate community venues in areas of high South Asian density across the UK. It has been estimated that randomising 720 participants (360 into each group) will be sufficient to detect a clinically important difference between a 55% recovery rate in the intervention group and a 40% recovery rate in the treatment-as-usual group. An economic analysis will estimate the cost-effectiveness of the positive health programme. A qualitative process evaluation will explore barriers and enablers to study participation and examine the acceptability and impact of the programme from the perspective of British South Asian women and other key stakeholders.

The Impact Of South Asian Cultural Violence

<div>This study explores the experiences and perspectives of first/second generation South Asian Canadian women on the representation of South Asian culture and violence against South Asian women. Specifically, this study looks at the myth of South Asian cultural violence, which views South Asian culture as inherently oppressive toward women and South Asian men as violent; and as a result, South Asian women are seen as victims of these men and their culture.</div><div>This study does not undermine violence against South Asian women, but challenges the ways in which violence against South Asian women gets talked about through the myth or the discourse of South Asian cultural violence. Both the state and (trans)national media play an important role in circulating this myth to further socio-political agendas. Centering the narratives of South Asian women in this study will show the ways in which they make meaning of the myth, as well as how they challenge and resist it. This study involves a focus group with two first/second generation South Asian Canadian women using arts-informed narrative methodology. Findings demonstrate that the discourse of South Asian cultural violence has had a significant impact on their relationship to themselves, other South Asians, and to the South Asian culture due to the ongoing encounter with stories of violence against South Asian women. </div>

The Impact Of South Asian Cultural Violence

<div>This study explores the experiences and perspectives of first/second generation South Asian Canadian women on the representation of South Asian culture and violence against South Asian women. Specifically, this study looks at the myth of South Asian cultural violence, which views South Asian culture as inherently oppressive toward women and South Asian men as violent; and as a result, South Asian women are seen as victims of these men and their culture.</div><div>This study does not undermine violence against South Asian women, but challenges the ways in which violence against South Asian women gets talked about through the myth or the discourse of South Asian cultural violence. Both the state and (trans)national media play an important role in circulating this myth to further socio-political agendas. Centering the narratives of South Asian women in this study will show the ways in which they make meaning of the myth, as well as how they challenge and resist it. This study involves a focus group with two first/second generation South Asian Canadian women using arts-informed narrative methodology. Findings demonstrate that the discourse of South Asian cultural violence has had a significant impact on their relationship to themselves, other South Asians, and to the South Asian culture due to the ongoing encounter with stories of violence against South Asian women. </div>

Studies to Improve Perinatal Health through Diet and Lifestyle among South Asian Women Living in Canada: A Brief History and Future Research Directions

South Asians (i.e., people who originate from India, Pakistan, Sri Lanka, Nepal, and Bangladesh) have higher cardiovascular disease rates than other populations, and these differences persist in their offspring. Nutrition is a critical lifestyle-related factor that influences fetal development, and infant and child health in early life. In high-income countries such as Canada, nutrition-related health risks arise primarily from overnutrition, most strikingly for obesity and associated non-communicable diseases. Evidence for developmental programming during fetal life underscores the critical influence of maternal diet on fetal growth and development, backed by several birth cohort studies including the Pune Maternal Nutrition Study, the South Asian Birth Cohort Study, and the Born in Bradford Study. Gestational diabetes mellitus is a strong risk factor for type 2 diabetes, future atherosclerosis and cardiovascular disease in the mother and increases the risk of type 2 diabetes in her offspring. Non-pharmacological trials to prevent gestational diabetes are few, often not randomized, and are heterogeneous with respect to design, and outcomes have not converged upon a single optimal prevention strategy. The aim of this review is to provide an understanding of the current knowledge around perinatal nutrition and gestational diabetes among the high-risk South Asian population as well as summarize our research activities investigating the role of culturally-tailored nutrition advice to South Asian women living in high-income settings such as Canada. In this paper, we describe these qualitative and quantitative studies, both completed and underway. We conclude with a description of the design of a randomized trial of a culturally tailored personalized nutrition intervention to reduce gestational glycaemia in South Asian women living in Canada and its implications.

Gestational diabetes mellitus: a qualitative study of lived experiences of South Asian immigrant women and perspectives of their health care providers in Melbourne, Australia

Background South Asian women are at a high risk of developing gestational diabetes mellitus than other women in Australia. Gestational diabetes affects up to 14–19% of all pregnancies among South Asian, South East Asian, and Arabic populations placing women at risk of adverse pregnancy outcomes. Although, gestational diabetes resolves after childbirth, women with gestational diabetes are up to seven times more likely to develop type 2 diabetes within five to ten years of the index pregnancy. Increasingly, South Asian women are being diagnosed with gestational diabetes in Australia. Therefore, we aimed to gain a better understanding of the lived experiences of South Asian women and their experiences of self-management and their health care providers’ perspectives of treatment strategies. Methods Using an ethnographic qualitative research methodology, semi-structured one-on-one, face-to-face interviews were conducted with 21 health care providers involved in gestational diabetes management and treatment from the three largest tertiary level maternity hospitals in Melbourne, Victoria, Australia. In-depth interviews were conducted with 23 South Asian women post diagnosis between 24–28 weeks gestation in pregnancy. Results Health care providers had challenges in providing care to South Asian women. The main challenge was to get women to self-manage their blood glucose levels with lifestyle modification. Whilst, women felt self-management information provided were inadequate and inappropriate to their needs. Women felt ‘losing control over their pregnancy’, because of being preoccupied with diet and exercise to control their blood glucose level. Conclusions The gestational diabetes clinical practice at the study hospitals were unable to meet consumer expectations. Health care providers need to be familiar of diverse patient cultures, rather than applying the current ‘one size fits all’ approach that failed to engage and meet the needs of immigrant and ethnic women. Future enabling strategies should aim to co-design and develop low Glycaemic Index diet plans of staple South Asian foods and lifestyle modification messages.

“I Like it Clean”: Brazilian Waxing and Postfeminist Subjectivity Among South Asian Beauticians in London

Postfeminism is a neoliberal sensibility that locates femininity in the body, thereby imploring women to constantly labor on, monitor and discipline their bodies. This aesthetic labor is presented to women as freely chosen and empowering. Brazilian waxing is exemplary aesthetic labor directed at the self. Academic literature on aesthetic labor in general, and Brazilian waxing in particular, looks at white and middle-class women, as this category of women is considered the putative subject of postfeminism. Little attention is paid to racialized women from the global south who perform aesthetic labor on other women’s bodies in the global north. In this paper, I draw on my ethnographic study of two beauty salons in London run by South Asian women to argue that these South Asian beauticians are postfeminist subjects as well. The aim of challenging the putative subject of postfeminism, using the example of Brazilian waxing, is not merely to include South Asian women in the discourse, but to advance a transnational theorization of postfeminism. Such theorization, I demonstrate, leads to a better understanding of how postfeminism is implicated in global structures of power as well as the affective qualities of postfeminism including intimacy and disgust.

South Asian immigrant women & abuse : identifying intersecting issues and culturally appropriate solutions

The current discourse and media portrayal of abused South Asian women is largely around depicting a pathological community, placing the blame of domestic violence within the South Asian community as an inherent result of South Asian culture. This paper aims moves [sic] away from a simplistic cultural interpretation of violence and utilizes an intersectional perspective for understanding multiple oppressions faced by abused South Asian women. Mapping key intersecting issues and analysis of gaps in the service provision in the domestic violence sector are undertaken through an in-depth literature review. An exploratory and descriptive case study method is adopted to explore a community-based organization's approach to culturally appropriate domestic violence intervention in the South Asian community. Case study findings recommend utilizing a culturally appropriate approach for understanding, engaging and intervening in domestic violence cases in the South Asian community. Community development, strengthening the family and a non-blame approach to addressing violence is recommended through the case study.