Oxidative Stress in Neonatal Lung Diseases

2019 ◽  
pp. 51-84
Author(s):  
Ru-Jeng Teng
Keyword(s):  
Oxidative Stress ◽  
Lung Diseases ◽  
Neonatal Lung

scholarly journals Mechanisms and consequences of oxidative stress in lung disease: therapeutic implications for an aging populace

2018 ◽  
Vol 314 (4) ◽  
pp. L642-L653 ◽  
Author(s):  
Louise Hecker
Keyword(s):  
Oxidative Stress ◽  
Lung Disease ◽  
Lung Diseases ◽  
The Elderly ◽  
Therapeutic Strategies ◽  
Rapid Expansion ◽  
Pulmonary Diseases ◽  
Normal Lung ◽  
Incidence And Mortality ◽  
And Oxidative Stress

The rapid expansion of the elderly population has led to the recent epidemic of age-related diseases, including increased incidence and mortality of chronic and acute lung diseases. Numerous studies have implicated aging and oxidative stress in the pathogenesis of various pulmonary diseases; however, despite recent advances in these fields, the specific contributions of aging and oxidative stress remain elusive. This review will discuss the consequences of aging on lung morphology and physiology, and how redox imbalance with aging contributes to lung disease susceptibility. Here, we focus on three lung diseases for which aging is a significant risk factor: acute respiratory distress syndrome (ARDS), chronic obstructive pulmonary disease (COPD), and idiopathic pulmonary fibrosis (IPF). Preclinical and clinical development for redox- and senescence-altering therapeutic strategies are discussed, as well as scientific advancements that may direct current and future therapeutic development. A deeper understanding of how aging impacts normal lung function, redox balance, and injury-repair processes will inspire the development of new therapies to prevent and/or reverse age-associated pulmonary diseases, and ultimately increase health span and longevity. This review is intended to encourage basic, clinical, and translational research that will bridge knowledge gaps at the intersection of aging, oxidative stress, and lung disease to fuel the development of more effective therapeutic strategies for lung diseases that disproportionately afflict the elderly.

Oxidative Stress and Smoke-Related Lung Diseases: A Tentative Approach Through the Blood, Lungs, and Gut

2019 ◽  
pp. 27-50
Author(s):  
Francesco Marotta ◽  
Jaganath Arunachalam ◽  
Antara Banerjee ◽  
Roberto Catanzaro ◽  
Sudhir Adalti ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lung Diseases

scholarly journals Pharmacological and genetic reappraisals of protease and oxidative stress pathways in a mouse model of obstructive lung diseases

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Tsuyoshi Shuto ◽  
Shunsuke Kamei ◽  
Hirofumi Nohara ◽  
Haruka Fujikawa ◽  
Yukihiro Tasaki ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mouse Model ◽  
Lung Diseases ◽  
Obstructive Lung Diseases ◽  
And Oxidative Stress

scholarly journals Oxidative Stress and Inflammation Modulate Rev-erbα Signaling in the Neonatal Lung and Affect Circadian Rhythmicity

2014 ◽  
Vol 21 (1) ◽  
pp. 17-32 ◽  
Author(s):  
Guang Yang ◽  
Clyde J. Wright ◽  
Maurice D. Hinson ◽  
Amal P. Fernando ◽  
Shaon Sengupta ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Circadian Rhythmicity ◽  
Neonatal Lung

scholarly journals Stem cell biology and regenerative medicine for neonatal lung diseases

2017 ◽  
Vol 83 (1-2) ◽  
pp. 291-297 ◽  
Author(s):  
Martin Kang ◽  
Bernard Thébaud
Keyword(s):  
Stem Cell ◽  
Regenerative Medicine ◽  
Cell Biology ◽  
Lung Diseases ◽  
Stem Cell Biology ◽  
Neonatal Lung
Sign in / Sign up

Export Citation Format

Share Document