Design Consideration for e-Rikshaw with Regeneration Capability

2021 ◽  
pp. 161-175
Author(s):  
Manoj Kumar ◽  
Amit Ojha
Micromachines ◽  
2021 ◽  
Vol 12 (8) ◽  
pp. 914
Author(s):  
Arsalan Ul Haq ◽  
Felicia Carotenuto ◽  
Paolo Di Nardo ◽  
Roberto Francini ◽  
Paolo Prosposito ◽  
...  

Myocardial infarction (MI) is the consequence of coronary artery thrombosis resulting in ischemia and necrosis of the myocardium. As a result, billions of contractile cardiomyocytes are lost with poor innate regeneration capability. This degenerated tissue is replaced by collagen-rich fibrotic scar tissue as the usual body response to quickly repair the injury. The non-conductive nature of this tissue results in arrhythmias and asynchronous beating leading to total heart failure in the long run due to ventricular remodelling. Traditional pharmacological and assistive device approaches have failed to meet the utmost need for tissue regeneration to repair MI injuries. Engineered heart tissues (EHTs) seem promising alternatives, but their non-conductive nature could not resolve problems such as arrhythmias and asynchronous beating for long term in-vivo applications. The ability of nanotechnology to mimic the nano-bioarchitecture of the extracellular matrix and the potential of cardiac tissue engineering to engineer heart-like tissues makes it a unique combination to develop conductive constructs. Biomaterials blended with conductive nanomaterials could yield conductive constructs (referred to as extrinsically conductive). These cell-laden conductive constructs can alleviate cardiac functions when implanted in-vivo. A succinct review of the most promising applications of nanomaterials in cardiac tissue engineering to repair MI injuries is presented with a focus on extrinsically conductive nanomaterials.


1985 ◽  
Vol 32 (8) ◽  
pp. 1484-1489 ◽  
Author(s):  
H. Ando ◽  
S. Ohba ◽  
M. Nakai ◽  
T. Ozaki ◽  
N. Ozawa ◽  
...  

1958 ◽  
Vol 4 (3) ◽  
pp. 283-305 ◽  
Author(s):  
J. L. King ◽  
P. Boyle ◽  
J. B. Ogle

A new water tunnel, incorporating a slotted wall working section, was found to suffer from severe vibration. A theoretical explanation is given for this, together with experimental evidence gleaned from this water tunnel and a small wind tunnel. It is shown that the oscillations are hydrodynamic in origin and are associated with the slotted wall design. Consideration is given to methods of elimination or reduction of the oscillations.


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