Tumor Microenvironment and Intracellular Signal-Activated Nanocomposites for Anticancer Drug Delivery

2021 ◽  
pp. 167-200
Author(s):  
Yilan Huang ◽  
Yiheng Huang ◽  
Yuefei Zhu ◽  
Xiaowen Zhu ◽  
Zhiqing Pang
Keyword(s):  
Drug Delivery ◽  
Tumor Microenvironment ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery ◽  
Intracellular Signal

Tumor Microenvironment Stimuli-Responsive Nanoparticles for Programmed Anticancer Drug Delivery

2020 ◽  
Vol 17 (5) ◽  
pp. 1516-1526 ◽  
Author(s):  
Nan Jia ◽  
Wenpan Li ◽  
Dan Liu ◽  
Shiyang Wu ◽  
Baohui Song ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Microenvironment ◽  
Anticancer Drug ◽  
Stimuli Responsive ◽  
Anticancer Drug Delivery

Multi-stimuli-responsive nanomicelles fabricated using synthetic polymer polylysine conjugates for tumor microenvironment dependent drug delivery

2020 ◽  
Vol 8 (26) ◽  
pp. 5745-5755
Author(s):  
Rimesh Augustine ◽  
Dae-Kyoung Kim ◽  
Nagendra Kalva ◽  
Kuen Hee Eom ◽  
Jae Ho Kim ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Microenvironment ◽  
Anticancer Drug ◽  
Tumor Targeting ◽  
Synthetic Polymer ◽  
Stimuli Responsive ◽  
Anticancer Drug Delivery ◽  
Temperature Responsive ◽  
Polymer Hybrid

A poly(lysine)-synthetic polymer hybrid nanomicelles were fabricated as promising platform for efficient tumor targeting and glutathione/pH/temperature-responsive anticancer drug delivery.

Thermo/redox/pH-triple sensitive poly(N-isopropylacrylamide-co-acrylic acid) nanogels for anticancer drug delivery

2015 ◽  
Vol 3 (20) ◽  
pp. 4221-4230 ◽  
Author(s):  
Yuan Zhan ◽  
Mara Gonçalves ◽  
Panpan Yi ◽  
Débora Capelo ◽  
Yuhong Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Microenvironment ◽  
Acrylic Acid ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery

Doxorubicin is effectively loaded into disulfide-crosslinked poly(N-isopropylacrylamide-co-acrylic acid) nanogels, which can be triggerably released in a heating or reducing acidic tumor microenvironment.

HER2-Mediated Anticancer Drug Delivery: Strategies to Prepare Targeting Ligands Highly Specific for the Receptor

2015 ◽  
Vol 22 (21) ◽  
pp. 2525-2538 ◽  
Author(s):  
Enrica Calce ◽  
Luca Monfregola ◽  
Michele Saviano ◽  
Stefania De Luca
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery ◽  
Delivery Strategies

Advances in Nanoparticles as Anticancer Drug Delivery Vector: Need of this Century

2020 ◽  
Vol 26 (15) ◽  
pp. 1637-1649 ◽  
Author(s):  
Imran Ali ◽  
Sofi D. Mukhtar ◽  
Heyam S. Ali ◽  
Marcus T. Scotti ◽  
Luciana Scotti
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Medical Science ◽  
Drug Carriers ◽  
Anticancer Drug Delivery ◽  
Ph Values ◽  
Delivery Vector ◽  
Future Challenges ◽  
Smart Drug ◽  
Smart Drug Delivery

Background: Nanotechnology has contributed a great deal to the field of medical science. Smart drugdelivery vectors, combined with stimuli-based characteristics, are becoming increasingly important. The use of external and internal stimulating factors can have enormous benefits and increase the targeting efficiency of nanotechnology platforms. The pH values of tumor vascular tissues are acidic in nature, allowing the improved targeting of anticancer drug payloads using drug-delivery vectors. Nanopolymers are smart drug-delivery vectors that have recently been developed and recommended for use by scientists because of their potential targeting capabilities, non-toxicity and biocompatibility, and make them ideal nanocarriers for personalized drug delivery. Method: The present review article provides an overview of current advances in the use of nanoparticles (NPs) as anticancer drug-delivery vectors. Results: This article reviews the molecular basis for the use of NPs in medicine, including personalized medicine, personalized therapy, emerging vistas in anticancer therapy, nanopolymer targeting, passive and active targeting transports, pH-responsive drug carriers, biological barriers, computer-aided drug design, future challenges and perspectives, biodegradability and safety. Conclusions: This article will benefit academia, researchers, clinicians, and government authorities by providing a basis for further research advancements.

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