Tumor Microenvironment Stimuli-Responsive Nanoparticles for Programmed Anticancer Drug Delivery

2020 ◽  
Vol 17 (5) ◽  
pp. 1516-1526 ◽  
Author(s):  
Nan Jia ◽  
Wenpan Li ◽  
Dan Liu ◽  
Shiyang Wu ◽  
Baohui Song ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Microenvironment ◽  
Anticancer Drug ◽  
Stimuli Responsive ◽  
Anticancer Drug Delivery

Multi-stimuli-responsive nanomicelles fabricated using synthetic polymer polylysine conjugates for tumor microenvironment dependent drug delivery

2020 ◽  
Vol 8 (26) ◽  
pp. 5745-5755
Author(s):  
Rimesh Augustine ◽  
Dae-Kyoung Kim ◽  
Nagendra Kalva ◽  
Kuen Hee Eom ◽  
Jae Ho Kim ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Microenvironment ◽  
Anticancer Drug ◽  
Tumor Targeting ◽  
Synthetic Polymer ◽  
Stimuli Responsive ◽  
Anticancer Drug Delivery ◽  
Temperature Responsive ◽  
Polymer Hybrid

A poly(lysine)-synthetic polymer hybrid nanomicelles were fabricated as promising platform for efficient tumor targeting and glutathione/pH/temperature-responsive anticancer drug delivery.

scholarly journals Stimuli-responsive nanofibers prepared from poly(N-isopropylacrylamide-acrylamide-vinylpyrrolidone) by electrospinning as an anticancer drug delivery

2013 ◽  
Vol 16 (6) ◽  
pp. 515-527 ◽  
Author(s):  
Roya Salehi ◽  
Mohammad Irani ◽  
Mohammad-Reza Rashidi ◽  
Abdolreza Aroujalian ◽  
Ahmadreza Raisi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Stimuli Responsive ◽  
Anticancer Drug Delivery

Thermo/redox/pH-triple sensitive poly(N-isopropylacrylamide-co-acrylic acid) nanogels for anticancer drug delivery

2015 ◽  
Vol 3 (20) ◽  
pp. 4221-4230 ◽  
Author(s):  
Yuan Zhan ◽  
Mara Gonçalves ◽  
Panpan Yi ◽  
Débora Capelo ◽  
Yuhong Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Microenvironment ◽  
Acrylic Acid ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery

Doxorubicin is effectively loaded into disulfide-crosslinked poly(N-isopropylacrylamide-co-acrylic acid) nanogels, which can be triggerably released in a heating or reducing acidic tumor microenvironment.

Peptide Sequence-Dominated Enzyme-Responsive Nanoplatform for Anticancer Drug Delivery

2019 ◽  
Vol 19 (1) ◽  
pp. 74-97 ◽  
Author(s):  
Yanan Li ◽  
Liping Du ◽  
Chunsheng Wu ◽  
Bin Yu ◽  
Hui Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Anticancer Drug ◽  
Drug Delivery Systems ◽  
Peptide Sequence ◽  
Stimuli Responsive ◽  
Property A ◽  
Anticancer Drug Delivery ◽  
Microenvironmental Factors ◽  
Responsive Element

Enzymatic dysregulation in tumor and intracellular microenvironments has made this property a tremendously promising responsive element for efficient diagnostics, carrier targeting, and drug release. When combined with nanotechnology, enzyme-responsive drug delivery systems (DDSs) have achieved substantial advancements. In the first part of this tutorial review, changes in tumor and intracellular microenvironmental factors, particularly the enzymatic index, are described. Subsequently, the peptide sequences of various enzyme-triggered nanomaterials are summarized for their uses in various drug delivery applications. Then, some other enzyme responsive nanostructures are discussed. Finally, the future opportunities and challenges are discussed. In brief, this review can provide inspiration and impetus for exploiting more promising internal enzyme stimuli-responsive nanoDDSs for targeted tumor diagnosis and treatment.

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