A three-locus system of interspecific incompatibility underlies male inviability in hybrids between Drosophila buzzatii and D. koepferae

To determine whether interspecific pollen transfer could reduce seed production by two sympatric lilies, Erythronium albidum and Erythronium americanum, we hand-pollinated flowers with mixtures of conspecific and heterospecific pollen. These species exhibited typical unilateral interspecific incompatibility, i.e., pollen tubes from the self-infertile species (E. americanum) grew apparently unimpeded in styles of the self-fertile species (E. albidum), whereas the reverse cross resulted in an incompatibility reaction. Because of this asymmetrical relation and faster growth by heterospecific pollen tubes in E. albidum stigmas than by conspecific tubes, pollination with abundant heterospecific pollen reduced fruit and seed production by E. albidum, but not by E. americanum, as long as the stigma also received some conspecific pollen. Unilateral incompatibility could benefit self-infertile species in reproductive interactions with closely related self-fertile species; however, this benefit remains to be demonstrated for naturally pollinated plants. Key words: Erythronium albidum, Erythronium americanum, interspecific pollen transfer, pollination, unilateral incompatibility.

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Breeding structure of natural populations of Drosophila buzzatii: effects of the distribution of larval substrates

Heredity ◽

10.1038/hdy.1990.44 ◽

1990 ◽

Vol 64 (3) ◽

pp. 355-365 ◽

Cited By ~ 17

Author(s):

Richard H Thomas ◽

J Stuart F Barker

Keyword(s):

Natural Populations ◽

Breeding Structure ◽

Drosophila Buzzatii

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Interspecific Incompatibility

Pollen Biology and Biotechnology ◽

10.1201/9780429187704-11 ◽

2019 ◽

pp. 167-175

Author(s):

K.R. Shivanna

Keyword(s):

Interspecific Incompatibility

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The Decay of Disease Association with Declining Linkage Disequilibrium: A Fine Mapping Theorem

10.1101/052381 ◽

2016 ◽

Cited By ~ 1

Author(s):

Mehdi Maadooliat ◽

Naveen K. Bansal ◽

Jiblal Upadhya ◽

Manzur R. Farazi ◽

Zhan Ye ◽

...

Keyword(s):

Monte Carlo ◽

Linkage Disequilibrium ◽

Fine Mapping ◽

Disease Model ◽

Disease Association ◽

Simple Relationship ◽

Locus System ◽

Using Data ◽

Relationship Of ◽

The Relationship

AbstractSeveral important and fundamental aspects of disease genetics models have yet to be described. One such property is the relationship of disease association statistics at a marker site closely linked to a disease causing site. A complete description of this two-locus system is of particular importance to experimental efforts to fine map association signals for complex diseases. Here, we present a simple relationship between disease association statistics and the decline of linkage disequilibrium from a causal site. A complete derivation of this relationship from a general disease model is shown for very large sample sizes. Quite interestingly, this relationship holds across all modes of inheritance. Extensive Monte Carlo simulations using a disease genetics model applied to chromosomes subjected to a standard model of recombination are employed to better understand the variation around this fine mapping theorem due to sampling effects. We also use this relationship to provide a framework for estimating properties of a non-interrogated causal site using data at closely linked markers. We anticipate that understanding the patterns of disease association decay with declining linkage disequilibrium from a causal site will enable more powerful fine mapping methods.

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Polymorphic Inversion and Esterase Loci Complex on Chromosome 2 of Drosophila buzzatii. I. Linkage Disequilibria

Australian Journal of Biological Sciences ◽

10.1071/bi9870257 ◽

1987 ◽

Vol 40 (3) ◽

pp. 257 ◽

Cited By ~ 17

Author(s):

WR Knibb ◽

PD East ◽

JSF Barker

Keyword(s):

New World ◽

Genetic Change ◽

Chromosome 2 ◽

Population Bottlenecks ◽

Linkage Disequilibria ◽

Drosophila Buzzatii ◽

Conditional Allele ◽

Esterase Loci ◽

Almost All ◽

Significant Linkage

Chromosome 2 inversion, Est-l and Est-2 haplotype frequencies were determined for 19 wild D. buzzatii collections from the known range of this species in Australia. Three different chromosome 2 sequences (ST, j, j z3) were polymorphic across the collections. They occurred at overall frequencies which approximated those in the ancestral New World and colonized Old World populations, which indicated that no radical genetic change was associated with the colonization of Australia by D. buzzatii. Linkage disequilibria of Est-l and Est-2 alleles with the inversions tended to be strong, and consistent in direction, in almost all collections. The distributions of conditional allele frequencies within the different inversions were consistent with stochastic historical explanations for the linkage disequilibria. Significant linkage disequilibria between Est-l and Est-2 were evident after correcting for the inversions, but these disequilibria largely were restricted to southern (higher latitude) populations, and were inconsistent in direction among the collections. Hence, population bottlenecks may underlie these genic disequilibria.

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