Differential effects of CGP 37849 and MK-801, competitive and noncompetitive NMDA antagonists, with respect to the modulation of sensorimotor gating and dopamine outflow in the prefrontal cortex of rats

1994 ◽  
Vol 350 (5) ◽  
pp. 555-562 ◽  
Author(s):  
Krzysztof Wędzony ◽  
Krystyna Gołembiowska ◽  
Magdalena Zazula
Keyword(s):  
Prefrontal Cortex ◽  
Sensorimotor Gating ◽  
Nmda Antagonists ◽  
Mk 801 ◽  
Differential Effects ◽  
Cgp 37849

scholarly journals Isoflurane and Propofol Block Neurotoxicity Caused by MK-801 in the Rat Posterior Cingulate/Retrosplenial Cortex

1997 ◽  
Vol 17 (2) ◽  
pp. 168-174 ◽  
Author(s):  
Vesna Jevtović-Todorović ◽  
Charity O. Kirby ◽  
John W. Olney
Keyword(s):  
Brain Injury ◽  
Neuronal Degeneration ◽  
Nmda Antagonist ◽  
Retrosplenial Cortex ◽  
Acute Brain Injury ◽  
Nmda Antagonists ◽  
General Anesthetics ◽  
General Anesthetic ◽  
Mk 801 ◽  
Anesthetic Agents

In acute brain injury syndromes, the potent N-methyl-D-aspartate (NMDA) antagonist, MK-801, can prevent neuronal degeneration, and the general anesthetics, isoflurane and propofol, may also provide neuroprotective benefits. An obstacle to the use of NMDA antagonists for neuroprotective purposes is that they can cause a neurotoxic vacuole reaction in cerebrocortical neurons. This study demonstrates the ability of isoflurane and propofol to prevent the neurotoxic vacuole reaction induced by MK-801. Low sedative doses of inhaled isoflurane (1%) or intravenous (i.v.) propofol (7.5 mg/kg/h) were as effective as higher general anesthetic doses. Thus, in the clinical management of acute brain injury conditions such as stroke and brain trauma, administration of one of these anesthetic agents together with an NMDA antagonist may be an excellent formula for obtaining optimal neuroprotection while eliminating serious side effects.

scholarly journals Global quantitative analysis of phosphorylation underlying phencyclidine signaling and sensorimotor gating in the prefrontal cortex

2015 ◽  
Vol 21 (2) ◽  
pp. 205-215 ◽  
Author(s):  
D B McClatchy ◽  
J N Savas ◽  
S Martínez-Bartolomé ◽  
S K Park ◽  
P Maher ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Quantitative Analysis ◽  
Sensorimotor Gating
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