Agmatine attenuated sensorimotor gating deficit in schizophrenia model in rats: combination of neonatal MK-801 and isolation rearing

2018 ◽  
Author(s):  
Feyza Aricioglu ◽  
Gokhan Unal
Keyword(s):  
Sensorimotor Gating ◽  
Isolation Rearing ◽  
Mk 801

scholarly journals A botanical drug composed of three herbal materials attenuates the sensorimotor gating deficit and cognitive impairment induced by MK‐801 in mice

2019 ◽  
Vol 72 (1) ◽  
pp. 149-160 ◽  
Author(s):  
Bokyung Koo ◽  
Ho Jung Bae ◽  
Nayeon Goo ◽  
Jaehoon Kim ◽  
Jihyun Kim ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Sensorimotor Gating ◽  
Mk 801 ◽  
Botanical Drug

scholarly journals Clerodendrum inermeLeaf Extract Alleviates Animal Behaviors, Hyperlocomotion, and Prepulse Inhibition Disruptions, Mimicking Tourette Syndrome and Schizophrenia

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Hon-Lie Chen ◽  
Hsin-Jung Lee ◽  
Wei-Jan Huang ◽  
Jui-Feng Chou ◽  
Pi-Chuan Fan ◽  
...  
Keyword(s):  
Tourette Syndrome ◽  
Prepulse Inhibition ◽  
Therapeutic Potential ◽  
Acoustic Startle ◽  
Acoustic Startle Response ◽  
Sensorimotor Gating ◽  
Ethanol Extract ◽  
Channel Blockers ◽  
Mk 801 ◽  
Animal Behaviors

Previously, we found a patient with intractable motor tic disorder, a spectrum of Tourette syndrome (TS), responsive to the ground leaf juice ofClerodendrum inerme(CI). Here, we examined the effect of the ethanol extract ofCIleaves (CIextract) on animal behaviors mimicking TS, hyperlocomotion, and sensorimotor gating deficit. The latter is also observed in schizophrenic patients and can be reflected by a disruption of prepulse inhibition of acoustic startle response (PPI) in animal models induced by methamphetamine and NMDA channel blockers (ketamine or MK-801), based on hyperdopaminergic and hypoglutamatergic hypotheses, respectively.CIextract (10–300 mg/kg,i.p.) dose-dependently inhibited hyperlocomotion induced by methamphetamine (2 mg/kg,i.p.) and PPI disruptions induced by methamphetamine, ketamine (30 mg/kg,i.p.), and MK-801 (0.3 mg/kg,i.p.) but did not affect spontaneous locomotor activity, rotarod performance, and grip force. These results suggest thatCIextract can relieve hyperlocomotion and improve sensorimotor gating deficit, supporting the therapeutic potential ofCIfor TS and schizophrenia.

The effect of zotepine, risperidone, clozapine and olanzapine on MK-801-disrupted sensorimotor gating

2005 ◽  
Vol 80 (4) ◽  
pp. 591-596 ◽  
Author(s):  
V BUBENIKOVA ◽  
M VOTAVA ◽  
J HORACEK ◽  
T PALENICEK ◽  
C DOCKERY
Keyword(s):  
Sensorimotor Gating ◽  
Mk 801
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