Effects of bile acids on ventricular muscle contraction and electrophysiological properties: studies in rat papillary muscle and isolated ventricular myocytes

1987 ◽  
Vol 335 (2) ◽  
Author(s):  
Ofer Binah ◽  
Irit Rubinstein ◽  
Arieh Bomzon ◽  
OriS. Better
Keyword(s):  
Muscle Contraction ◽  
Bile Acids ◽  
Papillary Muscle ◽  
Ventricular Myocytes ◽  
Ventricular Muscle ◽  
Electrophysiological Properties ◽  
Rat Papillary Muscle ◽  
Isolated Ventricular Myocytes

Effect of Iodothyronines on Electrophysiological Properties of Rat Papillary Muscle Fibres

1997 ◽  
Vol 29 (05) ◽  
pp. 225-230 ◽  
Author(s):  
S. Di Meo ◽  
P. Venditti ◽  
T. De Leo
Keyword(s):  
Papillary Muscle ◽  
Muscle Fibres ◽  
Electrophysiological Properties ◽  
Rat Papillary Muscle

Antiarrhythmic Effects of Magnesium on Rat Papillary Muscle and Guinea Pig Ventricular Myocytes

1999 ◽  
Vol 32 (1) ◽  
pp. 107-114 ◽  
Author(s):  
M. Aomine ◽  
Y. Tatsukawa ◽  
T. Yamato ◽  
S. Yamasaki
Keyword(s):  
Guinea Pig ◽  
Papillary Muscle ◽  
Ventricular Myocytes ◽  
Rat Papillary Muscle ◽  
Antiarrhythmic Effects

Effects of α-adrenoceptor stimulation on electrophysiological properties and mechanics in rat papillary muscle

1987 ◽  
Vol 18 (5) ◽  
pp. 539-546 ◽  
Author(s):  
Noritsugu Tohse ◽  
Yuichi Hattori ◽  
Haruaki Nakaya ◽  
Morio Kanno
Keyword(s):  
Papillary Muscle ◽  
Electrophysiological Properties ◽  
Rat Papillary Muscle

Reduced Contraction and Altered Frequency Response of Isolated Ventricular Myocytes From Patients With Heart Failure

Circulation ◽  
1995 ◽  
Vol 92 (9) ◽  
pp. 2540-2549 ◽  
Author(s):  
C.H. Davies ◽  
K. Davia ◽  
J.G. Bennett ◽  
J.R. Pepper ◽  
P.A. Poole-Wilson ◽  
...  
Keyword(s):  
Heart Failure ◽  
Frequency Response ◽  
Ventricular Myocytes ◽  
Patients With Heart Failure ◽  
Isolated Ventricular Myocytes

Mechanical restitution of the rat papillary muscle

1982 ◽  
Vol 115 (2) ◽  
pp. 183-191 ◽  
Author(s):  
KRISTÍN RAGNARSDÓTTIR ◽  
BJÖRN WOHLFART ◽  
MAGNÚS JÓHANNSSON
Keyword(s):  
Papillary Muscle ◽  
Mechanical Restitution ◽  
Rat Papillary Muscle

Adriamycin-induced alterations of the action potential in rat papillary muscle

1980 ◽  
Vol 14 (8) ◽  
pp. 446-450 ◽  
Author(s):  
M L LAZARUS ◽  
K L ROSSNER ◽  
K M ANDERSON
Keyword(s):  
Action Potential ◽  
Papillary Muscle ◽  
Rat Papillary Muscle

35.P3. Electrophysiological characteristics of freshly isolated ventricular myocytes from zebrafish (Danio rerio)

2007 ◽  
Vol 148 ◽  
pp. S152
Author(s):  
F. Brette ◽  
C. Cros ◽  
H. Dixey ◽  
C. Wilson ◽  
G. Luxan ◽  
...  
Keyword(s):  
Danio Rerio ◽  
Ventricular Myocytes ◽  
Isolated Ventricular Myocytes

Acute and specific collagen type I degradation increases diastolic and developed tension in perfused rat papillary muscle

2004 ◽  
Vol 286 (3) ◽  
pp. H889-H894 ◽  
Author(s):  
Regis R. Lamberts ◽  
Maurice J. J. M. F. Willemsen ◽  
Néstor G. Pérez ◽  
Pieter Sipkema ◽  
Nico Westerhof
Keyword(s):  
Papillary Muscle ◽  
Collagen Type ◽  
Perfusion Pressure ◽  
Collagen Type I ◽  
Type I ◽  
Collagenase Treatment ◽  
Before And After ◽  
Diastolic Coronary Flow ◽  
Rat Papillary Muscle

Collagen degradation is suggested to be responsible for long-term contractile dysfunction in different cardiomyopathies, but the effects of acute and specific collagen type I removal (main type in the heart muscle) on tension have not been studied. We determined the diastolic and developed tension length relations in isometric contracting perfused rat papillary muscles (perfusion pressure 60 cmH2O) before and after acute and specific removal of small collagen struts with the use of purified collagenase type I. At 95% of the maximal length (95% Lmax), diastolic tension increased 20.4 ± 8.1% ( P < 0.05, n = 6) and developed tension increased 15.0 ± 6.7% after collagenase treatment compared with time controls. Treatment increased the diastolic muscle diameter by 7.1 ± 3.4% at 95% Lmax, whereas the change in diameter due to contraction was not changed. Diastolic coronary flow and normalized coronary arterial flow impediment did not change after collagenase treatment. Electron microscopy revealed that the number of small collagen struts, interconnecting myocytes, and capillaries was reduced to ∼32% after treatment. We conclude that removal of the small collagen struts by acute and specific collagen type I degradation increases diastolic and developed tension in perfused papillary muscle. We suggest that diastolic tension is increased due to edema, whereas developed tension is increased because the removal of the struts poses a lower lateral load on the cardiac myocytes, allowing more myocyte thickening.

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