The role of lymph node cells in the inhibition of metastasis by subcutaneous injection of Lactobacillus casei in mice

1988 ◽  
Vol 177 (5) ◽  
Author(s):  
Takeshi Matsuzaki ◽  
Teruo Yokokura ◽  
Masahiko Mutai
Keyword(s):  
Lymph Node ◽  
Subcutaneous Injection ◽  
Lactobacillus Casei ◽  
Lymph Node Cells

scholarly journals Graft-vs.-Host Activity of Thymocytes: Relationship to the Role of Thymocytes in Hemopoiesis

Blood ◽  
1972 ◽  
Vol 39 (6) ◽  
pp. 850-861 ◽  
Author(s):  
Joan Wright Goodman ◽  
Kay T. Burch ◽  
Nancy L. Basford
Keyword(s):  
Lymph Node ◽  
F1 Hybrid ◽  
Radiation Chimeras ◽  
Lymph Node Cells ◽  
Per Se ◽  
Uptake Method ◽  
Better Than

Abstract The importance of graft-vs.-host (GVH) activity to the ability of thymocytes to augment hemopoiesis in radiation chimeras was investigated. Parental (P) lymph node cells were found by the 59Fe-uptake method not to have an analogous augmentative effect. When thymus donor, marrow donor, and irradiated recipient were chosen immunogenetically so that GVH could occur in either the presence or absence of graft-vs.-graft (GVG) activity, it was seen that GVH reactivity per se resulted in no improvement of marrow growth. However, when P thymocytes specifically tolerant to an F1 hybrid host were administered with P marrow, augmentation was three times greater than when nontolerant P thymocytes were given. It was concluded that GVH activity not only is not essential but actually is detrimental to augmentation. Ninety-day survival of chimeras given specifically tolerant P thymocytes was better than that of mice given P marrow only and very much better than those given marrow and nontolerant thymocytes.

scholarly journals CELLULAR REQUIREMENTS FOR THE REJECTION OF SKIN ALLOGRAFTS IN RATS

1973 ◽  
Vol 138 (2) ◽  
pp. 331-341 ◽  
Author(s):  
David M. Lubaroff
Keyword(s):  
Bone Marrow ◽  
Lymph Node ◽  
Bone Marrow Cells ◽  
Lymph Node Cell ◽  
Skin Reactions ◽  
Skin Allografts ◽  
Lymph Node Cells ◽  
Bone Marrow Derived Cells ◽  
Transplantation Antigens

The role of bone marrow-derived cells in the rejection of skin allografts in rats was investigated. Lewis rats, rendered tolerant of BN antigens and bearing healthy grafts, were thymectomized, irradiated with 900 rad, and injected with varying doses of either normal isologous bone marrow, normal lymph node cells, and/or lymph node cells presensitized to BN antigens. In some experiments rats were also adoptively sensitized to tuberculin. Results showed that, although necessary for the elicitation of tuberculin skin reactions, bone marrow cells are not needed for the rejection of previously tolerated skin allografts. Rats receiving lymph node cells alone rejected their grafts in about 6–7 days. In addition, rats injected with bone marrow alone also rejected their grafts, although significantly later than did lymph node cell recipients, indicating that rat marrow contains a population of cells capable of reacting to transplantation antigens. These cells were found capable of reacting to major transplantation antigens but not minor as they were ineffective in causing the rejection of Ag-B compatible Fischer skin grafts. From experiments utilizing bone marrow from neonatally thymectomized donors and cells treated with an antiserum to rat T cells, these competent cells in the marrow were shown to be thymus derived.

scholarly journals Evidence for a pathogenic role of a cell-mediated immune mechanism in experimental glomerulonephritis.

1978 ◽  
Vol 148 (1) ◽  
pp. 246-260 ◽  
Author(s):  
A K Bhan ◽  
E E Schneeberger ◽  
A B Collins ◽  
R T McCluskey
Keyword(s):  
Endothelial Cells ◽  
Lymph Node ◽  
Gamma Globulin ◽  
Mononuclear Cells ◽  
Immune Mechanism ◽  
Pathogenic Role ◽  
Glomerular Lesions ◽  
A Cell ◽  
Lymph Node Cells

Lewis rats were injected intravenously with rabbit anti-rat glomerular basement membrane (GBM) antisera in doses that were sufficient to cause glomerular fixation of rabbit gamma globulin (RGG) detectable by immunofluorescence, but which failed to induce histologically detectable lesions. 24 h later, groups of rats received lymph node cells or serum from syngeneic donors that had been immunized with either RGG or ovalbumin; they were injected with [3H]thymidine three times during the next 2 days, and sacrificed 48 or 96 h after transfer. Only the rats given anti-GBM antiserum plus lymph node cells from donors sensitized to RGG showed histological glomerular lesions, in the form of segmental hypercellularly and necrosis. Autoradiographs revealed the greatest number of labeled cells in glomeruli in the same group. In analogous experiments, it was shown that T-cell-enriched populations could induce hypercellular glomerular reactions. On the basis of electronmicroscopic and autoradiographic observations, it appears that the glomerular hypercellularity resulted from both infiltration of mononuclear cells and proliferation of endothelial cells. The findings indicate that interaction of specifically sensitized lymphocytes with glomerular-bound antigen can induce a cell-mediated (delayed-type) reaction in glomeruli.

Different cytokine profiles in mesenteric lymph node cells from HLA-B27 transgenic versus wild type rats stimulated with cecal bacterial antigen

2001 ◽  
Vol 120 (5) ◽  
pp. A516-A516
Author(s):  
F HOENTJEN ◽  
S TONKONOGY ◽  
D SPRENGERS ◽  
M GOERRES ◽  
R SARTOR ◽  
...  
Keyword(s):  
Lymph Node ◽  
Mesenteric Lymph Node ◽  
Bacterial Antigen ◽  
Hla B27 ◽  
Wild Type ◽  
Cytokine Profiles ◽  
Mesenteric Lymph ◽  
Lymph Node Cells

scholarly journals The Distribution and Utilization of Glucose in Isolated Lymph Node Cells

1959 ◽  
Vol 234 (8) ◽  
pp. 1958-1965 ◽  
Author(s):  
Ernst Helmreich ◽  
Herman N. Eisen
Keyword(s):  
Lymph Node ◽  
Lymph Node Cells

scholarly journals Synthesis and Secretion of γ-Globulin by Lymph Node Cells

1967 ◽  
Vol 242 (13) ◽  
pp. 3242-3244
Author(s):  
Robert M. Swenson ◽  
Milton Kern
Keyword(s):  
Lymph Node ◽  
Lymph Node Cells
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