Influence of thyroid hormones on the human ATP synthase β-subunit gene promoter

1996 ◽  
Vol 154 (2) ◽  
pp. 107-111 ◽  
Author(s):  
Immaculada Martin ◽  
Josep A. Villena ◽  
Marta Giralt ◽  
Roser Iglesias ◽  
Teresa Mampel ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Atp Synthase ◽  
Gene Promoter ◽  
Β Subunit ◽  
Subunit Gene

scholarly journals Mitochondrial ATP synthase is dispensable in blood-stage Plasmodium berghei rodent malaria but essential in the mosquito phase

2015 ◽  
Vol 112 (33) ◽  
pp. 10216-10223 ◽  
Author(s):  
Angelika Sturm ◽  
Vanessa Mollard ◽  
Anton Cozijnsen ◽  
Christopher D. Goodman ◽  
Geoffrey I. McFadden
Keyword(s):  
Atp Synthase ◽  
Plasmodium Berghei ◽  
Blood Stage ◽  
Mosquito Vector ◽  
Β Subunit ◽  
Subunit Gene ◽  
Parasite Life Cycle ◽  
Asexual Blood Stage ◽  
Rodent Malaria ◽  
Mitochondrial Atp Synthase

Mitochondrial ATP synthase is driven by chemiosmotic oxidation of pyruvate derived from glycolysis. Blood-stage malaria parasites eschew chemiosmosis, instead relying almost solely on glycolysis for their ATP generation, which begs the question of whether mitochondrial ATP synthase is necessary during the blood stage of the parasite life cycle. We knocked out the mitochondrial ATP synthase β subunit gene in the rodent malaria parasite, Plasmodium berghei, ablating the protein that converts ADP to ATP. Disruption of the β subunit gene of the ATP synthase only marginally reduced asexual blood-stage parasite growth but completely blocked mouse-to-mouse transmission via Anopheles stephensi mosquitoes. Parasites lacking the β subunit gene of the ATP synthase generated viable gametes that fuse and form ookinetes but cannot progress beyond this stage. Ookinetes lacking the β subunit gene of the ATP synthase had normal motility but were not viable in the mosquito midgut and never made oocysts or sporozoites, thereby abrogating transmission to naive mice via mosquito bite. We crossed the self-infertile ATP synthase β subunit knockout parasites with a male-deficient, self-infertile strain of P. berghei, which restored fertility and production of oocysts and sporozoites, which demonstrates that mitochondrial ATP synthase is essential for ongoing viability through the female, mitochondrion-carrying line of sexual reproduction in P. berghei malaria. Perturbation of ATP synthase completely blocks transmission to the mosquito vector and could potentially be targeted for disease control.

scholarly journals Thyrotropin-Releasing Hormone Stimulates the Activity of the Rat Thyrotropin β-Subunit Gene Promoter Transfected into Pituitary Cells

1989 ◽  
Vol 3 (4) ◽  
pp. 717-724 ◽  
Author(s):  
Frances E. Carr ◽  
Margaret A. Shupnik ◽  
Joan Burnside ◽  
William W. Chin
Keyword(s):  
Gene Promoter ◽  
Thyrotropin Releasing Hormone ◽  
Pituitary Cells ◽  
Β Subunit ◽  
Subunit Gene ◽  
Releasing Hormone

scholarly journals Thyroid Hormone Regulates the Mouse Thyrotropin β-Subunit Gene Promoter in Transfected Primary Thyrotropes

1989 ◽  
Vol 264 (25) ◽  
pp. 14840-14847 ◽  
Author(s):  
W M Wood ◽  
M Y Kao ◽  
D F Gordon ◽  
E C Ridgway
Keyword(s):  
Thyroid Hormone ◽  
Gene Promoter ◽  
Β Subunit ◽  
Subunit Gene

The human ATP synthase β subunit gene: Sequence analysis, chromosome assignment, and differential expression

Genomics ◽  
1989 ◽  
Vol 5 (4) ◽  
pp. 829-843 ◽  
Author(s):  
Nicolas Neckelmann ◽  
Cynthia K. Warner ◽  
Andrew Chung ◽  
Jun Kudoh ◽  
Shinsei Minoshima ◽  
...  
Keyword(s):  
Sequence Analysis ◽  
Differential Expression ◽  
Atp Synthase ◽  
Gene Sequence ◽  
Β Subunit ◽  
Subunit Gene ◽  
Chromosome Assignment ◽  
Gene Sequence Analysis

The chorionic gonadotropin β-subunit gene is controlled by Pitx1 and Egr1

2007 ◽  
Vol 115 (S 1) ◽  
Author(s):  
A Henke ◽  
M Simoni ◽  
E Nieschlag ◽  
J Gromoll
Keyword(s):  
Chorionic Gonadotropin ◽  
Β Subunit ◽  
Subunit Gene

Cloning and Analyzing of G-protein β-Subunit Gene in Rhizoctonia solani Causing Soybean Sharp Eyespot

2009 ◽  
Vol 35 (2) ◽  
pp. 370-374
Author(s):  
Bing-Tian MA ◽  
Guang-Lin QU ◽  
Wen-Juan HUANG ◽  
Yu-Fan LIN ◽  
Shi-Gui LI
Keyword(s):  
Rhizoctonia Solani ◽  
G Protein ◽  
Β Subunit ◽  
Subunit Gene ◽  
Sharp Eyespot
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