Neurosecretory axon regeneration into intrahypothalamic neural lobe allografts: neurophysin immunohistochemistry and fine structure

1987 ◽  
Vol 67 (3) ◽  
Author(s):  
H.D. Dellmann ◽  
L.F. Lue ◽  
S.I. Bellin
Keyword(s):  
Fine Structure ◽  
Axon Regeneration ◽  
Neural Lobe ◽  
Neurosecretory Axon

scholarly journals Intrahypothalamically Transected Neurosecretory Axons do not Regenerate in the Absence of Glial Cells

1993 ◽  
Vol 4 (2) ◽  
pp. 127-137 ◽  
Author(s):  
H.-Dieter Dellmann ◽  
Jeanine Carithers
Keyword(s):  
Extracellular Matrix ◽  
Optic Nerve ◽  
Sciatic Nerve ◽  
Glial Cells ◽  
Basal Lamina ◽  
Axon Regeneration ◽  
Neural Lobe ◽  
Hypothalamic Area ◽  
Nerve Grafts ◽  
Neurosecretory Axon

Fifteen days after transection of the hypothalamo-neurohypophysial tract at the lateral retrochiasmatic hypothalamic area, neurosecretory axons had vigorously regenerated into transplants of explanted hypophysial neural lobe, to a lesser extent into sciatic nerve transplants, and least into optic nerve transplants. Regenerating axons were always closely associated with the specific glial cells of these grafts. When these glial cells were killed by cryotreatment prior to transplantation, neurosecretory axons did not regenerate into the abundant extracellular matrix of the transplants, including persisting basal lamina tubes in neural lobe and sciatic nerve grafts. The presence of viable glial cells is a prerequisite for neurosecretory axon regeneration.

Magnocellular neurosecretory axon regeneration into rat intrahypothalamic optic nerve allografts

1989 ◽  
Vol 24 (2) ◽  
pp. 163-168 ◽  
Author(s):  
H.-D. Dellmann ◽  
L.-F. Lue ◽  
S. I. Bellin ◽  
M. Quassat
Keyword(s):  
Optic Nerve ◽  
Axon Regeneration ◽  
Neurosecretory Axon

HORMONAL CONTENT AND ULTRASTRUCTURE OF THE HYPOTHALAMO-NEUROHYPOPHYSIAL SYSTEM OF THE RAT AFTER INJECTION OF VINBLASTINE INTO THE MEDIAN EMINENCE

1977 ◽  
Vol 73 (2) ◽  
pp. 197-205 ◽  
Author(s):  
E. L. RODRÍGUEZ ◽  
ECHANDÍA, J. C. CAVICHIA ◽  
E. M. RODRÍGUEZ
Keyword(s):  
Electron Microscopy ◽  
Fine Structure ◽  
Median Eminence ◽  
Microscopic Analysis ◽  
Plasma Samples ◽  
Neural Lobe ◽  
Hormonal Content ◽  
Light Microscopic Analysis ◽  
Progressive Accumulation ◽  
Positive Materials

SUMMARY The effects of an injection of vinblastine (Vbl) into the median eminence on the structure, fine structure and antidiuretic hormone (ADH) content of the hypothalamo-neurohypophysial system in the rat is reported. The animals were studied on days 3, 8 and 25 after the injection of 1 or 5 mm-Vbl (3 μl). Significant changes were observed only in the 5 mm-Vbl-injected animals. Their median eminence extracts showed a progressive accumulation of ADH whereas ADH depletion occurred in the neural lobe extracts. On day 8 after injection, the animals exhibited strong polidipsia although considerable amounts of ADH still remained within the neural lobe. The ADH content of the plasma samples was consistently below the sensitivity of the method (5 μu.). The light microscopic analysis showed accumulation of Gomori-stainable products in the median eminence and a striking depletion of this material from the neural lobe. Electron microscopy revealed accumulation of neurosecretory vesicles and other inclusions proximal to the site of injection in the median eminence together with some evidence of nerve fibre degeneration. Few neurosecretory terminals were found in the neural lobe of the 8-day experimental rats. They had been engulfed by pituicytes for digestion. Recuperation of the normal ADH content of both median eminence and neural lobe was found to occur on day 25 after the Vbl injection. Simultaneously, the neural lobe refilled with Gomori-positive materials and neurosecretory terminals reappeared. The results suggest (1) reversible blockade of axoplasmic transport at the site of the Vbl injection; (2) reversible degeneration of neurosecretory terminals and (3) reversible blockade of ADH release in the surviving terminals of the neural lobe.

The destination of the aged, nonreleasable neurohypophyseal peptides stored in the neural lobe is associated to the remodeling of the neurosecretory axon

2005 ◽  
Vol 68 (6) ◽  
pp. 347-359 ◽  
Author(s):  
Juan Krsulovic ◽  
Bruno Peruzzo ◽  
Genaro Alvial ◽  
Carlos R. Yulis ◽  
Esteban M. Rodríguez
Keyword(s):  
Neural Lobe ◽  
Neurosecretory Axon

Pituicyte Fine Structure in the Developing Neural Lobe of the Rat

1981 ◽  
Vol 4 (2) ◽  
pp. 89-97 ◽  
Author(s):  
H.-Dieter Dellmann ◽  
Karin Sikora
Keyword(s):  
Fine Structure ◽  
Neural Lobe

The fine structure of the neural lobe of the mouse after transplantation under the kidney capsule

1981 ◽  
Vol 219 (2) ◽  
Author(s):  
Ewa Stach-Chilf ◽  
JerzyB. Warchol ◽  
Christoph Pilgrim
Keyword(s):  
Fine Structure ◽  
Neural Lobe ◽  
Kidney Capsule

On the fine structure of the perivascular cells in the neural lobe of rats

1972 ◽  
Vol 132 (1) ◽  
pp. 25-34 ◽  
Author(s):  
C. Olivieri-Sangiacomo
Keyword(s):  
Fine Structure ◽  
Perivascular Cells ◽  
Neural Lobe

An immunohistochemical and fine-structural analysis of peptidergic hypothalamic neurosecretory axon regeneration into the leptomeninges of the rat

1988 ◽  
Vol 450 (1-2) ◽  
pp. 181-189 ◽  
Author(s):  
H.-Dieter Dellmann ◽  
Lih-Fen Lue ◽  
Steven I. Bellin ◽  
Mohammed Ouassat
Keyword(s):  
Structural Analysis ◽  
Axon Regeneration ◽  
Neurosecretory Axon

Fine structure of a neurosecretory axon in a crustacean skeletal muscle

1972 ◽  
Vol 28 (8) ◽  
pp. 950-951 ◽  
Author(s):  
H. Huddart ◽  
S. J. Bradbury
Keyword(s):  
Skeletal Muscle ◽  
Fine Structure ◽  
Neurosecretory Axon
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