Preprotachykinin gene expression in the mediobasal hypothalamus of estrogen-treated and ovariectomized control rats

1989 ◽  
Vol 76 (1) ◽  
Author(s):  
G.J. Romano ◽  
T.I. Bonner ◽  
D.W. Pfaff
Keyword(s):  
Gene Expression ◽  
Mediobasal Hypothalamus ◽  
Preprotachykinin Gene

scholarly journals Induction of Type 2 Iodothyronine Deiodinase in the Mediobasal Hypothalamus by Bacterial Lipopolysaccharide: Role of Corticosterone

Endocrinology ◽  
2008 ◽  
Vol 149 (5) ◽  
pp. 2484-2493 ◽  
Author(s):  
Edith Sánchez ◽  
Praful S. Singru ◽  
Csaba Fekete ◽  
Ronald M. Lechan
Keyword(s):  
Gene Expression ◽  
Third Ventricle ◽  
Significant Rise ◽  
Bacterial Lipopolysaccharide ◽  
Mediobasal Hypothalamus ◽  
Sprague Dawley ◽  
Iodothyronine Deiodinase ◽  
Circulating Levels

To determine whether endotoxin-induced activation of type 2 iodothyronine deiodinase (D2) in the mediobasal hypothalamus is dependent on circulating levels of corticosterone, the effect of bacterial lipopolysaccharide (LPS) on D2 gene expression was studied in adrenalectomized, corticosterone-clamped adult, male, Sprague Dawley rats. In sham-adrenalectomized animals, LPS (250 μg/100 g body weight) increased circulating levels of corticosterone and IL-6, as well as tanycyte D2 mRNA in the mediobasal hypothalamus. Adrenalectomized, corticosterone-clamped animals showed no significant rise in corticosterone after LPS, compared with saline-treated controls but increased IL-6 levels and tanycyte D2 mRNA similar to LPS-treated sham controls. To further clarify the potential role of corticosterone in the regulation of D2 gene expression by LPS, animals were administered high doses of corticosterone to attain levels similar to that observed in the LPS-treated group. No significant increase in D2 mRNA was observed in the mediobasal hypothalamus with the exception of a small subpopulation of cells in the lateral walls of the third ventricle. These data indicate that the LPS-induced increase in D2 mRNA in the mediobasal hypothalamus is largely independent of circulating corticosterone and indicate that mechanisms other than adrenal activation are involved in the regulation of most tanycyte D2-expressing cells by endotoxin.

Regulation of Preprotachykinin Gene Expression by Nerve Growth Factor

1991 ◽  
Vol 632 (1 Substance P a) ◽  
pp. 391-393 ◽  
Author(s):  
C. A. GILCHRIST ◽  
C. MORRISON ◽  
A. J. HARMAR
Keyword(s):  
Gene Expression ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Nerve Growth ◽  
Preprotachykinin Gene

Developmental Profile of Striatal Preprotachykinin Gene Expression

1990 ◽  
Vol 55 (3) ◽  
pp. 764-768 ◽  
Author(s):  
Doris M. Haverstick ◽  
Michael Jeziorski ◽  
Michael J. Bannon
Keyword(s):  
Gene Expression ◽  
Developmental Profile ◽  
Preprotachykinin Gene

Preprotachykinin Gene Expression in the Forebrain: Regulation by Dopamine

1991 ◽  
Vol 632 (1 Substance P a) ◽  
pp. 31-37 ◽  
Author(s):  
MICHAEL J. BANNON ◽  
DORIS M. HAVERSTICK ◽  
KAZUHIKO SHIBATA ◽  
MICHAEL S. POOSCH
Keyword(s):  
Gene Expression ◽  
Preprotachykinin Gene

Differential regional effects of long-term l-DOPA treatment on preproenkephalin and preprotachykinin gene expression in the striatum of 6-hydroxydopamine-lesioned rat

1997 ◽  
Vol 47 (1-2) ◽  
pp. 311-321 ◽  
Author(s):  
Pascal Salin ◽  
Gustavo Dziewczapolski ◽  
Oscar S Gershanik ◽  
André Nieoullon ◽  
Rita Raisman-Vozari
Keyword(s):  
Gene Expression ◽  
Regional Effects ◽  
Preprotachykinin Gene ◽  
6 Hydroxydopamine
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