Localization of substance P, CGRP, VIP, neuropeptide Y, and somatostatin immunoreactive nerve fibers in the carotid labyrinths of some amphibian species

Immunohistochemistry revealed the presence of VIP-, NPY- and SP-immunoreactivity in the rat adrenal medulla. VIP- and NPY-immunoreactivity was detected in chromaffin and ganglion cells and in nerve fibers, but SP-immunoreactivity was found only in chromaffin cells. After acute heat stress, VIP- and NPY- immunoreactivities in cells and nerve fibers were reduced, probably as a result of the release of these peptides with catecholamines. The absence of SP-immunoreactive ganglion cells in the adrenal medulla suggests that the SP-immunoreactive nerve fibers are extrinsic in origin.

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Neuropeptides in the Cerebral Circulation: Relevance to Headache

Cephalalgia ◽

10.1046/j.1468-2982.1995.1504272.x ◽

1995 ◽

Vol 15 (4) ◽

pp. 272-276 ◽

Cited By ~ 77

Author(s):

L Edvinsson ◽

PJ Goadsby

Keyword(s):

Substance P ◽

Cluster Headache ◽

Neuropeptide Y ◽

Vasoactive Intestinal Peptide ◽

Cerebral Circulation ◽

Nasal Congestion ◽

Cerebral Arteries ◽

Nerve Fibers ◽

Peptide Release ◽

Associated Symptoms

The article briefly describes the innervation of the human cerebral circulation by nerve fibers containing neuropeptide Y (NPY), vasoactive intestinal peptide (VIP), substance P (SP), and calcitonin gent-related peptide (CGRP). The neuropeptides in human cerebral arteries were characterized by radioimmunoassay in combination with HPLC. These neuropeptides mediate contraction (NPY) and dilatation (VIP, SP, CGRP). In conjunction with spontaneous attacks of migraine or cluster headache, release of CGRP is seen. With the associated symptoms of nasal congestion and rhinorrhea, VIP is released. Successful treatment may abort the peptide release in parallel with disappearance of headache.

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Nerve fibers immunoreactive to protein gene product 9.5, calcitonin gene-related peptide, substance P, and neuropeptide Y in the dental pulp, periodontal ligament, and gingiva in cats

Acta Odontologica Scandinavica ◽

10.3109/00016359309040569 ◽

1993 ◽

Vol 51 (4) ◽

pp. 207-221 ◽

Cited By ~ 53

Author(s):

Karin J. Heyeraas ◽

Inger Kvinnsland ◽

Margaret R. Byers ◽

Ellen B. Jacobsen

Keyword(s):

Substance P ◽

Neuropeptide Y ◽

Gene Product ◽

Dental Pulp ◽

Periodontal Ligament ◽

Protein Gene ◽

Nerve Fibers ◽

Protein Gene Product 9.5 ◽

Protein Gene Product ◽

Calcitonin Gene

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Immunohistochemical evidence for the presence of a Vasoactive Intestinal Peptide, Neuropeptide Y, and Substance P, in rat adrenal cortex after acute heat stress

Archives of Biological Sciences ◽

10.2298/abs1301315k ◽

2013 ◽

Vol 65 (1) ◽

pp. 315-320

Author(s):

Dragana Petrovic-Kosanovic ◽

Mirela Ukropina ◽

Maja Cakic-Milosevic ◽

Mirela Budec ◽

Verica Milosevic ◽

...

Keyword(s):

Heat Stress ◽

Substance P ◽

Neuropeptide Y ◽

Blood Vessels ◽

Vasoactive Intestinal Peptide ◽

Adrenal Cortex ◽

Nerve Fibers ◽

Cortical Cells ◽

Acute Heat Stress ◽

Immunohistochemical Evidence

Immunohistochemistry revealed the presence of Vasoactive Intestinal Peptide (VIP), Neuropeptide Y (NPY), and the absence of Substance P (SP) immunoreactivity in the rat adrenal cortex. VIP- and NPY-immunoreactivity were detected in nerve fibers around the small blood vessels projecting into the capsule and cortical zones surrounding blood vessels and cortical cells. After acute heat stress, VIP- and NPY-immunoreactivities in the nerve fibers were reduced, probably as a result of the release of these peptides.

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