scholarly journals Immunohistochemical evidence for the presence of a vasoactive intestinal peptide, neuropeptide Y and substance P in rat adrenal medulla after heat stress

2012 ◽  
Vol 64 (1) ◽  
pp. 7-13
Author(s):  
Dragana Petrovic-Kosanovic ◽  
Vesna Koko
Keyword(s):  
Heat Stress ◽  
Substance P ◽  
Neuropeptide Y ◽  
Vasoactive Intestinal Peptide ◽  
Adrenal Medulla ◽  
Chromaffin Cells ◽  
Ganglion Cells ◽  
Nerve Fibers ◽  
Acute Heat Stress ◽  
Immunohistochemical Evidence

Immunohistochemistry revealed the presence of VIP-, NPY- and SP-immunoreactivity in the rat adrenal medulla. VIP- and NPY-immunoreactivity was detected in chromaffin and ganglion cells and in nerve fibers, but SP-immunoreactivity was found only in chromaffin cells. After acute heat stress, VIP- and NPY- immunoreactivities in cells and nerve fibers were reduced, probably as a result of the release of these peptides with catecholamines. The absence of SP-immunoreactive ganglion cells in the adrenal medulla suggests that the SP-immunoreactive nerve fibers are extrinsic in origin.

scholarly journals Immunohistochemical evidence for the presence of a Vasoactive Intestinal Peptide, Neuropeptide Y, and Substance P, in rat adrenal cortex after acute heat stress

2013 ◽  
Vol 65 (1) ◽  
pp. 315-320
Author(s):  
Dragana Petrovic-Kosanovic ◽  
Mirela Ukropina ◽  
Maja Cakic-Milosevic ◽  
Mirela Budec ◽  
Verica Milosevic ◽  
...  
Keyword(s):  
Heat Stress ◽  
Substance P ◽  
Neuropeptide Y ◽  
Blood Vessels ◽  
Vasoactive Intestinal Peptide ◽  
Adrenal Cortex ◽  
Nerve Fibers ◽  
Cortical Cells ◽  
Acute Heat Stress ◽  
Immunohistochemical Evidence

Immunohistochemistry revealed the presence of Vasoactive Intestinal Peptide (VIP), Neuropeptide Y (NPY), and the absence of Substance P (SP) immunoreactivity in the rat adrenal cortex. VIP- and NPY-immunoreactivity were detected in nerve fibers around the small blood vessels projecting into the capsule and cortical zones surrounding blood vessels and cortical cells. After acute heat stress, VIP- and NPY-immunoreactivities in the nerve fibers were reduced, probably as a result of the release of these peptides.

Decreased levels of [Met]enkephalin, neuropeptide Y, substance P, and vasoactive intestinal peptide in parkinsonian adrenal medulla

1991 ◽  
Vol 114 (1) ◽  
pp. 23-27 ◽  
Author(s):  
Susan L. Stoddard ◽  
Gertrude M. Tyce ◽  
J.Eric Ahlskog ◽  
Alan R. Zinsmeister ◽  
Daniel K. Nelson ◽  
...  
Keyword(s):  
Substance P ◽  
Neuropeptide Y ◽  
Vasoactive Intestinal Peptide ◽  
Adrenal Medulla

Neuropeptides in the Cerebral Circulation: Relevance to Headache

Cephalalgia ◽  
1995 ◽  
Vol 15 (4) ◽  
pp. 272-276 ◽  
Author(s):  
L Edvinsson ◽  
PJ Goadsby
Keyword(s):  
Substance P ◽  
Cluster Headache ◽  
Neuropeptide Y ◽  
Vasoactive Intestinal Peptide ◽  
Cerebral Circulation ◽  
Nasal Congestion ◽  
Cerebral Arteries ◽  
Nerve Fibers ◽  
Peptide Release ◽  
Associated Symptoms

The article briefly describes the innervation of the human cerebral circulation by nerve fibers containing neuropeptide Y (NPY), vasoactive intestinal peptide (VIP), substance P (SP), and calcitonin gent-related peptide (CGRP). The neuropeptides in human cerebral arteries were characterized by radioimmunoassay in combination with HPLC. These neuropeptides mediate contraction (NPY) and dilatation (VIP, SP, CGRP). In conjunction with spontaneous attacks of migraine or cluster headache, release of CGRP is seen. With the associated symptoms of nasal congestion and rhinorrhea, VIP is released. Successful treatment may abort the peptide release in parallel with disappearance of headache.

scholarly journals Vasomotor Responses of Rat Intracerebral Arterioles to Vasoactive Intestinal Peptide, Substance P, Neuropeptide Y, and Bradykinin

1988 ◽  
Vol 8 (2) ◽  
pp. 254-261 ◽  
Author(s):  
Ralph G. Dacey ◽  
John E. Bassett ◽  
Masakazu Takayasu
Keyword(s):  
Smooth Muscle ◽  
Substance P ◽  
Neuropeptide Y ◽  
Vasoactive Intestinal Peptide ◽  
Vessel Diameter ◽  
Cerebral Microcirculation ◽  
Vasoactive Peptides ◽  
Spontaneous Tone ◽  
Ph Dependent ◽  
Dose Dependent

The effect of vasoactive peptides on vascular smooth muscle in the cerebral microcirculation was examined using an isolated intracerebral arteriole preparation. Extraluminally applied vasoactive intestinal peptide (VIP) dilated the spontaneous tone of intracerebral arterioles to 118.9 ± 3.1% of control diameter at pH 7.30, with an EC50 of 7.27 × 10−8 M. Similar degrees of dilation to VIP were seen in vessels preconstricted by changing bath solution to pH 7.60. Substance P had no effect on vessel diameter at pH 7.30. However, in vessels precontracted by pH 7.60, significant dose-dependent dilation was observed with an EC50 of 2.55 × 10−10 M. Neuropeptide constricted intracerebral arterioles to 8l.22 ± 2.7% of control diameter, with an EC50 of 6.23 × 10−10 M. Bradykinin dilated intracerebral arterioles at pH 7.30 and pH 7.60 to 130 ± 3.0% of control diameter. VIP and bradykinin are potent vasodilators of intracerebral arterioles. Neuropeptide Y is a vasoconstrictor. The effect of substance P appeared to be either pH-dependent or dependent on some degree of precontraction by another agonist, but no effect on vessel diameter was seen at pH 7.30.

Ganglioneuroma of the Adrenal Medulla in Rats A Report of 3 cases

1970 ◽  
Vol 7 (2) ◽  
pp. 139-144 ◽  
Author(s):  
Glen C. Todd ◽  
Emmett C. Pierce ◽  
William G. Clevinger
Keyword(s):  
Adrenal Medulla ◽  
Ganglion Cells ◽  
Nerve Fibers ◽  
Well Differentiated

Three cases of ganglioneuroma of the adrenal medulla from Wistar-derived rata were described. These tumor were similar histologically, composed of large ganglion cells and nerve fibers. Associated with one of the ganglioneuromas was a well-differentiated pheochromocytoma.

Chemotactic activities of vasoactive intestinal peptide, neuropeptide Y and substance P in Leishmania braziliensis

2020 ◽  
Vol 219 ◽  
pp. 108009
Author(s):  
Michelle Giammarressi ◽  
Oriana Vanegas ◽  
Anthony Febres ◽  
Adrián Silva-López ◽  
Emilia Diaz López ◽  
...  
Keyword(s):  
Substance P ◽  
Neuropeptide Y ◽  
Vasoactive Intestinal Peptide ◽  
Leishmania Braziliensis
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