scholarly journals Evidence of delayed ?-cell destruction in Type 1 (insulin-dependent) diabetic patients with persisting complement-fixing cytoplasmic islet cell antibodies

Diabetologia ◽  
1984 ◽  
Vol 27 (4) ◽  
pp. 421-426 ◽  
Author(s):  
A. Mustonen ◽  
M. Knip ◽  
N. -P. Huttunen ◽  
R. Puukka ◽  
M. -L. K��r ◽  
...  
Keyword(s):  
Islet Cell ◽  
Islet Cell Antibodies ◽  
Diabetic Patients ◽  
Cell Destruction ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

scholarly journals Increased reduction in fasting C-peptide is associated with islet cell antibodies in Type 1 (insulin-dependent) diabetic patients

Diabetologia ◽  
1985 ◽  
Vol 28 (12) ◽  
pp. 875-880 ◽  
Author(s):  
B. Marner ◽  
T. Agner ◽  
C. Binder ◽  
�. Lernmark ◽  
J. Nerup ◽  
...  
Keyword(s):  
Islet Cell ◽  
Islet Cell Antibodies ◽  
Diabetic Patients ◽  
C Peptide ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

State of the Art: Islet Cell Antibody Tests

1987 ◽  
Vol 13 (4) ◽  
pp. 381-385 ◽  
Author(s):  
Paula M. Hale ◽  
Timothy J. Pasquarello ◽  
Pnina Vardi
Keyword(s):  
Beta Cell ◽  
Islet Cell ◽  
Islet Cell Antibodies ◽  
Islet Cell Antibody ◽  
Diabetic Patients ◽  
Diabetes Research ◽  
Beta Cell Destruction ◽  
Cell Destruction ◽  
Dependent Cell ◽  
Insulin Dependent

The discovery of anti-islet cell antibodies (ICAb's) in the sera of individuals with insulin- dependent diabetes (IDDM) was a significant milestone in the history of diabetes research. ICAb's have been found in the sera of 60%-85% of new-onset diabetic patients. It has been suggested that ICAb's play a role in the destruction of beta cells possibly by complement- mediated beta cell lysis, or by acting as mediators in antibody- dependent cell-mediated cytotoxicity. ICAb's have been shown to be markers of ongoing beta cell destruction. The presence of ICAb's has preceded the appearance of clinical evidence of IDDM by as long as eight years. The detection of ICAb's in first-degree relatives of individuals with IDDM identifies a population at risk for developing IDDM. Means of intervention need to be established to prevent progressive beta cell destruction in these individuals.

scholarly journals Glucose-induced changes in renal haemodynamics in proteinuric Type 1 (insulin-dependent) diabetic patients: inhibition by acetylsalicilic acid infusion

Diabetologia ◽  
1993 ◽  
Vol 36 (7) ◽  
pp. 622-627 ◽  
Author(s):  
S. De Cosmo ◽  
K. Earle ◽  
A. Morocutti ◽  
J. Walker ◽  
P. Ruggenenti ◽  
...  
Keyword(s):  
Renal Haemodynamics ◽  
Diabetic Patients ◽  
Acid Infusion ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic ◽  
Induced Changes
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