An unidentified macromolecular inhibitory constituent of calcium oxalate crystal growth in human urine

1990 ◽  
Vol 18 (6) ◽  
pp. 373-379 ◽  
Author(s):  
S. S�rensen ◽  
K. Hansen ◽  
S. Bak ◽  
S. J. Justesen
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Human Urine ◽  
Calcium Oxalate Crystal

Mannan-binding lectin (MBL)-associated plasma protein present in human urine inhibits calcium oxalate crystal growth

FEBS Letters ◽  
1999 ◽  
Vol 462 (1-2) ◽  
pp. 89-93 ◽  
Author(s):  
Insug Kang ◽  
Jin-Il Kim ◽  
Sung-Goo Chang ◽  
Sun-Ju Lee ◽  
Sang-Lim Choi ◽  
...  
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Plasma Protein ◽  
Human Urine ◽  
Calcium Oxalate Crystal ◽  
Mannan Binding Lectin ◽  
Binding Lectin

Acidic peptide and polyribonucleotide crystal growth inhibitors in human urine

1977 ◽  
Vol 233 (5) ◽  
pp. F455-F463 ◽  
Author(s):  
H. Ito ◽  
F. L. Coe
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Human Urine ◽  
Gel Filtration ◽  
Subsequent Treatment ◽  
Calcium Oxalate Crystal ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity ◽  
Acidic Peptide ◽  
Gastric Pepsin

Urine contains nondialyzable inhibitors of calcium oxalate crystal growth. We have pursued the hypothesis that these inhibitors may, in part, be acidic peptides and polyribonucleotide fragments. Homopolyribonucleotides and RNA inhibit calcium oxalate crystal growth at 5 x 10(-6) M of constituent ribonucleotide, whereas the monomer nucleotides are inactive at 10(-4) M. Poly-L-aspartic or glutamic acid are also inhibitory at 5 X 10(-6) M of amino acid, whereas the monomeric amino acids are inert. Gastric pepsin, a naturally occurring acidic peptide, is inhibitory. Incubation with nonspecific protease reduced the inhibitory effectiveness of normal human urine consistently and significantly, a fact compatible with an important contribution of peptides. A variable additional reduction was produced by subsequent treatment with ribonuclease, suggesting only a small role for polyribonucleotide. Sequential ion exchange and gel filtration chromatography and preparative disc gel electrophoresis yielded inhibitory material enriched with peptides that were strongly acidic and high in proline. Peptides and ribonucleotides seem to contribute to urinary nondialyzable crystal growth inhibitory activity.

Characterization of the Calcium Oxalate Crystal Growth Inhibitors in Human Urine

Urolithiasis ◽  
1981 ◽  
pp. 579-588 ◽  
Author(s):  
E. E. Schrier ◽  
J. L. Rubin ◽  
K. E. Lee ◽  
P. G. Werness ◽  
L. H. Smith
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Human Urine ◽  
Growth Inhibitors ◽  
Calcium Oxalate Crystal

Macromolecules inhibit calcium oxalate crystal growth and aggregation in whole human urine

1987 ◽  
Vol 167 (3) ◽  
pp. 329-338 ◽  
Author(s):  
Katherine A. Edyvane ◽  
Catherine M. Hibberd ◽  
Ruth M. Harnett ◽  
Villis R. Marshall ◽  
Rosemary L. Ryall
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Human Urine ◽  
Calcium Oxalate Crystal

Inhibition of Calcium Oxalate Crystal Growth in Patients with Urolithiasis

Urolithiasis ◽  
1981 ◽  
pp. 623-629 ◽  
Author(s):  
Hans-Göran Tiselius ◽  
Lasse Larsson
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Calcium Oxalate Crystal
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