Calcium oxalate crystal matrix extract: the most potent macromolecular inhibitor of crystal growth and aggregation yet tested in undiluted human urine in vitro

1995 ◽  
Vol 23 (1) ◽  
pp. 53-62 ◽  
Author(s):  
I. R. Doyle ◽  
V. R. Marshall ◽  
C. J. Dawson ◽  
R. L. Ryall
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Human Urine ◽  
Calcium Oxalate Crystal ◽  
Crystal Matrix

Mannan-binding lectin (MBL)-associated plasma protein present in human urine inhibits calcium oxalate crystal growth

FEBS Letters ◽  
1999 ◽  
Vol 462 (1-2) ◽  
pp. 89-93 ◽  
Author(s):  
Insug Kang ◽  
Jin-Il Kim ◽  
Sung-Goo Chang ◽  
Sun-Ju Lee ◽  
Sang-Lim Choi ◽  
...  
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Plasma Protein ◽  
Human Urine ◽  
Calcium Oxalate Crystal ◽  
Mannan Binding Lectin ◽  
Binding Lectin

An unidentified macromolecular inhibitory constituent of calcium oxalate crystal growth in human urine

1990 ◽  
Vol 18 (6) ◽  
pp. 373-379 ◽  
Author(s):  
S. S�rensen ◽  
K. Hansen ◽  
S. Bak ◽  
S. J. Justesen
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Human Urine ◽  
Calcium Oxalate Crystal

Acidic peptide and polyribonucleotide crystal growth inhibitors in human urine

1977 ◽  
Vol 233 (5) ◽  
pp. F455-F463 ◽  
Author(s):  
H. Ito ◽  
F. L. Coe
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Human Urine ◽  
Gel Filtration ◽  
Subsequent Treatment ◽  
Calcium Oxalate Crystal ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity ◽  
Acidic Peptide ◽  
Gastric Pepsin

Urine contains nondialyzable inhibitors of calcium oxalate crystal growth. We have pursued the hypothesis that these inhibitors may, in part, be acidic peptides and polyribonucleotide fragments. Homopolyribonucleotides and RNA inhibit calcium oxalate crystal growth at 5 x 10(-6) M of constituent ribonucleotide, whereas the monomer nucleotides are inactive at 10(-4) M. Poly-L-aspartic or glutamic acid are also inhibitory at 5 X 10(-6) M of amino acid, whereas the monomeric amino acids are inert. Gastric pepsin, a naturally occurring acidic peptide, is inhibitory. Incubation with nonspecific protease reduced the inhibitory effectiveness of normal human urine consistently and significantly, a fact compatible with an important contribution of peptides. A variable additional reduction was produced by subsequent treatment with ribonuclease, suggesting only a small role for polyribonucleotide. Sequential ion exchange and gel filtration chromatography and preparative disc gel electrophoresis yielded inhibitory material enriched with peptides that were strongly acidic and high in proline. Peptides and ribonucleotides seem to contribute to urinary nondialyzable crystal growth inhibitory activity.

scholarly journals IN VITRO STUDIES ON CALCIUM OXALATE CRYSTAL GROWTH INHIBITION OF STROBILANTHES CRISPUS EXTRACTS

2015 ◽  
Vol 3 (1) ◽  
pp. 8
Author(s):  
Afrizal Itam ◽  
Zhari Ismail ◽  
Amin Malik Shah Abdul Majid
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Sodium Citrate ◽  
Water Extract ◽  
Positive Control ◽  
Calcium Oxalate Crystal ◽  
Strobilanthes Crispus ◽  
Crystal Growth Inhibition ◽  
Acetone Extracts

 ABSTRACT Strobilanthes crispus L. (Acanthaceae) has been used locally in traditional medicine for kidney stone and related diseases. These plant extracts have the ability to inhibit the calcium oxalate crystal growth, where the ability of water extract is higher than those of the 70% acetone, methanol and acetone extracts. The ability to inhibit the calcium oxalate crystal growth of these extracts is lower than that of sodium citrate as positive control. Keywords: Strobilanthes crispus, Acanthaceae, crystal inhibition, calcium oxalate

scholarly journals FKBP-12 Exhibits an Inhibitory Activity on Calcium Oxalate Crystal Growth in Vitro

2002 ◽  
Vol 17 (1) ◽  
pp. 41 ◽  
Author(s):  
In Sook Han ◽  
Yasushi Nakagawa ◽  
Jong Wook Park ◽  
Min Ho Suh ◽  
Sung IL Suh ◽  
...  
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Inhibitory Activity ◽  
Calcium Oxalate Crystal

Characterization of the Calcium Oxalate Crystal Growth Inhibitors in Human Urine

Urolithiasis ◽  
1981 ◽  
pp. 579-588 ◽  
Author(s):  
E. E. Schrier ◽  
J. L. Rubin ◽  
K. E. Lee ◽  
P. G. Werness ◽  
L. H. Smith
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Human Urine ◽  
Growth Inhibitors ◽  
Calcium Oxalate Crystal
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