Calcium-activated potassium channels in the luminal membrane of Amphiuma diluting segment: voltage-dependent block by intracellular Na+ upon depolarisation

1990 ◽  
Vol 416 (4) ◽  
pp. 422-427 ◽  
Author(s):  
Katsumasa Kawahara ◽  
Malcolm Hunter ◽  
Gerhard Giebisch
Keyword(s):  
Potassium Channels ◽  
Diluting Segment ◽  
Luminal Membrane ◽  
Voltage Dependent ◽  
Calcium Activated Potassium Channels

Parathyroid hormone-related protein-mediated responses in pulmonary arteries and veins of newborn lambs

2005 ◽  
Vol 289 (1) ◽  
pp. L60-L66 ◽  
Author(s):  
Yuansheng Gao ◽  
J. Usha Raj
Keyword(s):  
Potassium Channels ◽  
Pulmonary Arteries ◽  
Phosphodiesterase Inhibitor ◽  
Intracellular Camp ◽  
Camp Content ◽  
Parathyroid Hormone Related Protein ◽  
Voltage Dependent ◽  
Calcium Activated Potassium Channels ◽  
And Function ◽  
Arteries And Veins

PTHrP has important roles in lung development and function. Here we determined the vasomotor responses of isolated pulmonary arteries and veins of newborn and adult sheep to PTHrP. In vessels constricted with endothelin-1, PTHrP (PTHrP 1-34) caused greater relaxation of veins than of arteries. In both vessel types, relaxation to the peptide was less in adult than in newborn vessels. In newborn lambs, PTHrP-induced relaxation was not affected by endothelium removal, inhibition of eNOS, or inhibition of adenylyl cyclases by SQ-22536. However, relaxation was attenuated by 4-aminopyridine, inhibitor of voltage-dependent potassium channels, in both arteries and veins, and by charybdotoxin, inhibitor of calcium-activated potassium channels, in veins. When vessels were saturated with 8-BrcAMP (3 × 10−4 M), to eliminate relaxation mediated by endogenous cAMP, PTHrP-induced relaxation was partially attenuated. In vessels treated with 8-BrcAMP (3 × 10−4 M), 4-aminopyridine but not charybdotoxin inhibited relaxation induced by PTHrP 1-34 in both arteries and veins. Radioimmunoassay showed that, in the presence of a general phosphodiesterase inhibitor, PTHrP caused a concentration-dependent increase in intracellular cAMP content in arteries and veins, which was largely abolished by SQ-22536. Our results demonstrate that PTHrP is a potent vasodilator of pulmonary vessels, with a greater effect in veins than in arteries. Relaxation induced by the peptide contains both cAMP-dependent and -independent components. In both arteries and veins, voltage-dependent potassium channels mediate the response to PTHrP, at least in part, in a cAMP-independent fashion; and in veins, calcium-activated potassium channels may be stimulated by elevated cAMP levels.

Voltage-dependent Sodium Channels and Calcium-activated Potassium Channels in Human Odontoblasts In Vitro

2012 ◽  
Vol 38 (10) ◽  
pp. 1355-1362 ◽  
Author(s):  
Hideki Ichikawa ◽  
Hyong-Jung Kim ◽  
Apichai Shuprisha ◽  
Tetsuo Shikano ◽  
Maki Tsumura ◽  
...  
Keyword(s):  
Potassium Channels ◽  
Sodium Channels ◽  
Voltage Dependent ◽  
Calcium Activated Potassium Channels

Voltage-dependent opening of single calcium-activated potassium channels in Helix neurons

1989 ◽  
Vol 488 (1-2) ◽  
pp. 336-340 ◽  
Author(s):  
Hélène Chagneux ◽  
Christian Ducreux ◽  
Maurice Gola
Keyword(s):  
Potassium Channels ◽  
Voltage Dependent ◽  
Calcium Activated Potassium Channels ◽  
Helix Neurons

scholarly journals Interaction between tetraethylammonium and amino acid residues in the pore of cloned voltage-dependent potassium channels.

1991 ◽  
Vol 266 (12) ◽  
pp. 7583-7587
Author(s):  
M P Kavanaugh ◽  
M D Varnum ◽  
P B Osborne ◽  
M J Christie ◽  
A E Busch ◽  
...  
Keyword(s):  
Amino Acid ◽  
Potassium Channels ◽  
Amino Acid Residues ◽  
Voltage Dependent

scholarly journals Modulation of calcium-activated potassium channels from rat brain by protein kinase A and phosphatase 2A

1991 ◽  
Vol 11 (6) ◽  
pp. 1627-1635 ◽  
Author(s):  
PH Reinhart ◽  
S Chung ◽  
BL Martin ◽  
DL Brautigan ◽  
IB Levitan
Keyword(s):  
Protein Kinase ◽  
Potassium Channels ◽  
Protein Kinase A ◽  
Rat Brain ◽  
Phosphatase 2A ◽  
Calcium Activated Potassium Channels ◽  
Kinase A

[125I]Iberiotoxin-D19Y/Y36F, the First Selective, High Specific Activity Radioligand for High-Conductance Calcium-Activated Potassium Channels

Biochemistry ◽  
1997 ◽  
Vol 36 (7) ◽  
pp. 1943-1952 ◽  
Author(s):  
Alexandra Koschak ◽  
Robert O. Koch ◽  
Jessica Liu ◽  
Gregory J. Kaczorowski ◽  
Peter H. Reinhart ◽  
...  
Keyword(s):  
Potassium Channels ◽  
Specific Activity ◽  
High Specific Activity ◽  
Calcium Activated Potassium Channels ◽  
High Conductance

Obesity Up-Regulates Intermediate Conductance Calcium-Activated Potassium Channels and Myoendothelial Gap Junctions to Maintain Endothelial Vasodilator Function

2010 ◽  
Vol 335 (2) ◽  
pp. 284-293 ◽  
Author(s):  
Preet S. Chadha ◽  
Rebecca E. Haddock ◽  
Lauren Howitt ◽  
Margaret J. Morris ◽  
Tim V. Murphy ◽  
...  
Keyword(s):  
Potassium Channels ◽  
Gap Junctions ◽  
Calcium Activated Potassium Channels
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